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Entry version 103 (02 Dec 2020)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

HECT and RLD domain-containing E3 ubiquitin protein ligase 3

Gene

herc3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1014Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathwayPROSITE-ProRule annotationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HECT and RLD domain-containing E3 ubiquitin protein ligase 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:herc3Imported
Synonyms:si:ch73-190m4.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-090313-139, herc3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B8JLD4

PeptideAtlas

More...
PeptideAtlasi
B8JLD4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000075887, Expressed in mature ovarian follicle and 26 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000123243

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 52RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati53 – 102RCC1PROSITE-ProRule annotationAdd BLAST50
Repeati103 – 155RCC1PROSITE-ProRule annotationAdd BLAST53
Repeati156 – 208RCC1PROSITE-ProRule annotationAdd BLAST53
Repeati209 – 260RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati261 – 312RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati314 – 377RCC1PROSITE-ProRule annotationAdd BLAST64
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini720 – 1046HECTInterPro annotationAdd BLAST327

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0941, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158189

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002173_5_3_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVEYDAF

Database of Orthologous Groups

More...
OrthoDBi
1062377at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B8JLD4

TreeFam database of animal gene trees

More...
TreeFami
TF315189

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078, HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00632, HECT, 1 hit
PF00415, RCC1, 7 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633, RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119, HECTc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50985, SSF50985, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237, HECT, 1 hit
PS00626, RCC1_2, 3 hits
PS50012, RCC1_3, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B8JLD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLCWGSSGA GQLGIGASEA SVFEPRSCCV FDGRGLKEVA CGNQHSLFLL
60 70 80 90 100
HDGSVYTCGS NSCGQLGHDK GGSRPELVGA LDAQKISGVS CGQAHSLAVN
110 120 130 140 150
EQGQVFAWGA GDGGQLGLGT AEEAVRVPRL IKKLCEHRIS QVMCGNHHCI
160 170 180 190 200
ALSKDGQLFV WGENSSGQLG LGKGEPSTLS PQPLKSLCGI PLTQISAGGD
210 220 230 240 250
HSFALSFSGA VFGWGKNSAG QLGLNDEQDR AVPCHIKFLR SQKVVYISCG
260 270 280 290 300
EEHTAALTKE GGLFTFGNGS KGQLGHDSTR NEPLPRRVME LMGTEVSQIA
310 320 330 340 350
CGRNHTLAFV PSTGLIYAFG CNTQGQLGTG IRGSAKSPVP VSNIQPLCIG
360 370 380 390 400
NAYTRTEHCT IAKIHSGGDH NFLLLSTVEG LSCPDDFRIL NTTKSIALIN
410 420 430 440 450
SESLDSWRMK LHDNSDSSIT NDIILLLSST ACWNASFLDQ SDDGHFKTNP
460 470 480 490 500
KVPGIDFNAV RLLFETLMKP AFARLLEQIT KSFESLLIPQ LPCSPPDVEA
510 520 530 540 550
MRIYLILSEC PAFQDSKNYI TLTIPLAMAI LRLDANPSKV LDNWWSLMDC
560 570 580 590 600
TVFTRLVEMY KSIVVFLLTG GKALLMPVFL ESYTSAALRL LEKLHKVNLK
610 620 630 640 650
AHRVEYNHFY IPDIATLVDI QEDYLKWFLR KADIKMRYPP VQGSVTLCAY
660 670 680 690 700
PFILNAQAKT TVLQTDAELQ MQMAVSGANL HNVFMLLTME PLLARNPFLV
710 720 730 740 750
LHVRRNHLVS DALRELTIYN DVDLKKPLKV IFDGEEAVDA GGVTKEFFLL
760 770 780 790 800
LLKELMNPIY GMFTQYSESN LLWFSDKCFV EHNWFHLIGI ICGLAIYNST
810 820 830 840 850
VVDLHFPLVL YKKLLEISPT LDDLKELSPT EGRSLQQLLE FEGDVEETFC
860 870 880 890 900
LNFAITREYY GITEVKELVQ GGKTIAVDKT NRKEFVQAYL QYVFSDAVQE
910 920 930 940 950
QYSAFSSGFL KVCGGEILSL FQPSELMAMV VGNNNYNWEE MEKNASYKGE
960 970 980 990 1000
FSATHPTVKM FWEVFHEFSL EKKKQFLLFL TGSDRIPIHG MASLRIVIQS
1010 1020 1030 1040
TAAEEHYLPV AHTCYNMLDM PCYQTKETLR QRLTQAVEQY EGFSLV
Length:1,046
Mass (Da):115,855
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1924D48313C98BF0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU467858 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001139096.1, NM_001145624.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000141977; ENSDARP00000123243; ENSDARG00000075887

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100003587

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:100003587

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU467858 Genomic DNA No translation available.
RefSeqiNP_001139096.1, NM_001145624.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000123243

Proteomic databases

PaxDbiB8JLD4
PeptideAtlasiB8JLD4

Genome annotation databases

EnsembliENSDART00000141977; ENSDARP00000123243; ENSDARG00000075887
GeneIDi100003587
KEGGidre:100003587

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8916
ZFINiZDB-GENE-090313-139, herc3

Phylogenomic databases

eggNOGiKOG0941, Eukaryota
GeneTreeiENSGT00940000158189
HOGENOMiCLU_002173_5_3_1
OMAiHVEYDAF
OrthoDBi1062377at2759
PhylomeDBiB8JLD4
TreeFamiTF315189

Enzyme and pathway databases

ReactomeiR-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSDARG00000075887, Expressed in mature ovarian follicle and 26 other tissues

Family and domain databases

CDDicd00078, HECTc, 1 hit
Gene3Di2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
PfamiView protein in Pfam
PF00632, HECT, 1 hit
PF00415, RCC1, 7 hits
PRINTSiPR00633, RCCNDNSATION
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SUPFAMiSSF50985, SSF50985, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS00626, RCC1_2, 3 hits
PS50012, RCC1_3, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB8JLD4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B8JLD4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 2, 2020
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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