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Protein

Integrin alpha-9

Gene

Itga9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi313 – 321Sequence analysis9
Calcium bindingi374 – 382Sequence analysis9
Calcium bindingi436 – 444Sequence analysis9

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: MGI
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • neutrophil chemotaxis Source: MGI
  • wound healing Source: Ensembl

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-445144 Signal transduction by L1

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-9Curated
Gene namesi
Name:Itga9Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:104756 Itga9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 981ExtracellularCuratedAdd BLAST953
Transmembranei982 – 1002HelicalSequence analysisAdd BLAST21
Topological domaini1003 – 1036CytoplasmicCuratedAdd BLAST34

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000043191429 – 1036Integrin alpha-9Sequence analysisAdd BLAST1008

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi88 ↔ 98By similarity
Disulfide bondi143 ↔ 163By similarity
Disulfide bondi180 ↔ 195By similarity
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi483 ↔ 492By similarity
Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi498 ↔ 556By similarity
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi621 ↔ 626By similarity
Disulfide bondi697 ↔ 707By similarity
Glycosylationi808N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi856 ↔ 892By similarity
Disulfide bondi899 ↔ 904By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei566 – 567CleavageSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiB8JK39
PaxDbiB8JK39
PeptideAtlasiB8JK39
PRIDEiB8JK39

PTM databases

iPTMnetiB8JK39
PhosphoSitePlusiB8JK39

Expressioni

Gene expression databases

BgeeiENSMUSG00000039115 Expressed in 261 organ(s), highest expression level in ascending aorta
ExpressionAtlasiB8JK39 baseline and differential
GenevisibleiB8JK39 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-9 (ITGA9) associates with beta-1 (ITGB1) (Probable). Integrin ITGA9:ITGB1 interacts with FBLN5 (via N-terminus) (PubMed:11805835).1 Publication1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044227

Structurei

3D structure databases

ProteinModelPortaliB8JK39
SMRiB8JK39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 97FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati109 – 175FG-GAP 2PROSITE-ProRule annotationAdd BLAST67
Repeati183 – 233FG-GAP 3PROSITE-ProRule annotationAdd BLAST51
Repeati234 – 290FG-GAP 4PROSITE-ProRule annotationAdd BLAST57
Repeati291 – 350FG-GAP 5PROSITE-ProRule annotationAdd BLAST60
Repeati352 – 409FG-GAP 6PROSITE-ProRule annotationAdd BLAST58
Repeati412 – 475FG-GAP 7PROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1006 – 1010GFFKR motifBy similarity5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00930000150849
HOGENOMiHOG000088626
HOVERGENiHBG004538
InParanoidiB8JK39
KOiK06585
OMAiYWTGTVK
OrthoDBiEOG091G011V
PhylomeDBiB8JK39
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B8JK39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGPAAARTG AGGLRALLLA LVAAGVPAGA YNLDAQRPVR FQGPSGSFFG
60 70 80 90 100
YAVLEHFHDN TRWVLVGAPK ADSKYSTSVK SPGAVFKCRV HTNPDRRCTE
110 120 130 140 150
LDMARGRTRG APCGKTCRGD RDDEWMGVSL ARQPRADGRV LACAHRWKNI
160 170 180 190 200
YYEADHILPH GFCYLIPSNL QAKGKVLIPC YEEYKKKYGE EHGSCQAGIA
210 220 230 240 250
GFFTEELVVM GAPGSFYWAG TLKVLNLTDN TYFKLNDEAI MNRRYTYLGY
260 270 280 290 300
AVTAGHFSHP SITDVVGGAP QDEGIGKVYI FRADRRSGTL IKIFQASGKK
310 320 330 340 350
MGSYFGSSLC AVDLNMDGLS DLLVGAPMFS EIRDEGQVTV YLNQGHGALE
360 370 380 390 400
EQLTLTGDAA YNAHFGESIA NLGDIDDDGF PDVAVGAPKE EDFAGAVYIY
410 420 430 440 450
HGDANGIVPK YSMKLSGRRL NPTLRMFGQS ISGGIDMDGN GYPDVTIGAF
460 470 480 490 500
LSDSVVLLRA RPVITVDVSI FLPGSINITA PQCHDGQQPV NCLNVTVCFR
510 520 530 540 550
FHGKNVPGEI GLNYNLTADV AQKEKGQLPR VYFVLFGETA GQVSERLQLS
560 570 580 590 600
HMDEVCHHYV AHVKRRVQDV ISPIVFEAAY SLDEHVMGEE DRELPDLTPV
610 620 630 640 650
LRWKKGQRIS QKNQTVFERN CQSEDCAADL QLRGKLLLSS VDEKTPHLAL
660 670 680 690 700
GAVKNISLNI SISNLGDDAY DANVSFNVSR ELFFINMWQK EEMGISCELL
710 720 730 740 750
ESDFLKCSVG FPFMRSKSKY EFSVIFDTSH LSGEEEILSF IVTAQSGNLE
760 770 780 790 800
RSEALHDNTL TLTVPLVHEV DTSITGIVSP TSFVYGESVD ASNFIQLDDQ
810 820 830 840 850
ECHFQPVNIT LQVYNMGPST LPGSSVSISF PSRLSPGGAE MFQVQDMVVS
860 870 880 890 900
QEKGNCSLQR NPTPCIIPQE QENIFHTIFA FFSKSGRKVL DCEKPGSFCL
910 920 930 940 950
TLHCNLSALP KEESRTINLY MLLNTEILKK DSSSVIQFMA RAKVKVEPAL
960 970 980 990 1000
RVVEIANGNP EETLVVFEAL HNLEPRGYVV GWIIAISLLV GILIFLLLAV
1010 1020 1030
LLWKMGFFRR RYKEIIEAEK NRKENEDGWD WVQKNQ
Length:1,036
Mass (Da):114,416
Last modified:March 3, 2009 - v1
Checksum:iF14BDEA82670FFCD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAP0E9QAP0_MOUSE
Integrin alpha-9
Itga9
450Annotation score:
F7DB81F7DB81_MOUSE
Integrin alpha-9
Itga9
175Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291I → V in AAI50825 (PubMed:15489334).Curated1
Sequence conflicti918N → D in AAI50825 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156800 Genomic DNA No translation available.
AC159000 Genomic DNA No translation available.
AC165257 Genomic DNA No translation available.
CT486004 Genomic DNA No translation available.
BC150824 mRNA Translation: AAI50825.1
CCDSiCCDS23604.1
RefSeqiNP_598482.2, NM_133721.2
UniGeneiMm.335520

Genome annotation databases

EnsembliENSMUST00000044165; ENSMUSP00000044227; ENSMUSG00000039115
GeneIDi104099
KEGGimmu:104099
UCSCiuc009rzw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156800 Genomic DNA No translation available.
AC159000 Genomic DNA No translation available.
AC165257 Genomic DNA No translation available.
CT486004 Genomic DNA No translation available.
BC150824 mRNA Translation: AAI50825.1
CCDSiCCDS23604.1
RefSeqiNP_598482.2, NM_133721.2
UniGeneiMm.335520

3D structure databases

ProteinModelPortaliB8JK39
SMRiB8JK39
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044227

PTM databases

iPTMnetiB8JK39
PhosphoSitePlusiB8JK39

Proteomic databases

MaxQBiB8JK39
PaxDbiB8JK39
PeptideAtlasiB8JK39
PRIDEiB8JK39

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044165; ENSMUSP00000044227; ENSMUSG00000039115
GeneIDi104099
KEGGimmu:104099
UCSCiuc009rzw.2 mouse

Organism-specific databases

CTDi3680
MGIiMGI:104756 Itga9

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00930000150849
HOGENOMiHOG000088626
HOVERGENiHBG004538
InParanoidiB8JK39
KOiK06585
OMAiYWTGTVK
OrthoDBiEOG091G011V
PhylomeDBiB8JK39
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-445144 Signal transduction by L1

Miscellaneous databases

ChiTaRSiItga9 mouse
PROiPR:B8JK39
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039115 Expressed in 261 organ(s), highest expression level in ascending aorta
ExpressionAtlasiB8JK39 baseline and differential
GenevisibleiB8JK39 MM

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITA9_MOUSE
AccessioniPrimary (citable) accession number: B8JK39
Secondary accession number(s): B9EKC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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