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Entry version 79 (08 May 2019)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Predicted gene 20547

Gene

Gm20547

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-173736 Alternative complement activation
R-MMU-174577 Activation of C3 and C5
R-MMU-977606 Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Predicted gene 20547Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gm20547Imported
Synonyms:C2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:5142012 Gm20547

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500287286319 – 1276Sequence analysisAdd BLAST1258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi643 ↔ 670PROSITE-ProRule annotation
Disulfide bondi703 ↔ 730PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B8JJN0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B8JJN0

PeptideAtlas

More...
PeptideAtlasi
B8JJN0

PRoteomics IDEntifications database

More...
PRIDEi
B8JJN0

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B8JJN0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000092511 Expressed in 18 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B8JJN0 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000117677

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B8JJN0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 75SushiInterPro annotationAdd BLAST56
Domaini92 – 150SushiInterPro annotationAdd BLAST59
Domaini179 – 306VWFAInterPro annotationAdd BLAST128
Domaini318 – 600Peptidase S1InterPro annotationAdd BLAST283
Domaini547 – 612SushiInterPro annotationAdd BLAST66
Domaini613 – 672SushiInterPro annotationAdd BLAST60
Domaini675 – 732SushiInterPro annotationAdd BLAST58
Domaini782 – 981VWFAInterPro annotationAdd BLAST200
Domaini989 – 1269Peptidase S1InterPro annotationAdd BLAST281

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627 Eukaryota
COG5640 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158605

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038034

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B8JJN0

TreeFam database of animal gene trees

More...
TreeFami
TF330194

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 4 hits
cd00190 Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028341 Complement_B
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46393:SF1 PTHR46393:SF1, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 3 hits
PF00089 Trypsin, 2 hits
PF00092 VWA, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 4 hits
SM00020 Tryp_SPc, 2 hits
SM00327 VWA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 2 hits
SSF53300 SSF53300, 2 hits
SSF57535 SSF57535, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 5 hits
PS50240 TRYPSIN_DOM, 2 hits
PS00134 TRYPSIN_HIS, 2 hits
PS00135 TRYPSIN_SER, 1 hit
PS50234 VWFA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B8JJN0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLLALFYL LQLGPGLAAL FCNQNVNITG GNFTLSHGWA PGSLLIYSCP
60 70 80 90 100
LGRYPSPAWR KCQSNGQWLT PRSSSHHTLR SSRMVKAVCK PSHCPNPGIS
110 120 130 140 150
VGTARTGLNF DLGDKVRYRC SSSNMVLTGS AERECQSNGV WSGSEPICRQ
160 170 180 190 200
PYSYDFPEDV ASALDTSLTN LLGATNPTQN LLTNHENATG TNTYEVLIRV
210 220 230 240 250
YSMMQSQMDR LGMETSAWKE IRHTIILLTD GKSNMGDSPK KAVTRIRELL
260 270 280 290 300
SIEQNRDDYL DIYAIGVGKL DVDWKELNEL GSKKDGERHA FILQDAKALQ
310 320 330 340 350
QIFEHMLDVS KLTDTICGVG NMSANASDQE RTPWQVTFKP KSKETCQGSL
360 370 380 390 400
ISDQWVLTAA HCFHDIQMED HHLWRVNVGD PTSQHGKEFL VEDVIIAPGF
410 420 430 440 450
NVHAKRKQGI SEFYADDIAL LKLSRKVKMS THARPICLPC TVGANMALRR
460 470 480 490 500
SPGSTCKDHE TELLSQQKVP AHFVALNGNR LNINLRTGPE WTRCIQAVSQ
510 520 530 540 550
NKNIFPSLTN VSEVVTDQFL CSGMEEEDDN PCKGVSATPV LEARPQVSCS
560 570 580 590 600
LEGVEIKGGS FQLLQGGQAL EYLCPSGFYP YPVQTRTCRS TGSWSDLQTR
610 620 630 640 650
DQKIVQKAEC RAIRCPRPQD FENGEFWPRS PFYNLSDQIS FQCYDGYVLR
660 670 680 690 700
GSANRTCQEN GRWDGQTAIC DDGAGYCPNP GIPIGTRKVG SQYRLEDIVT
710 720 730 740 750
YHCSRGLVLR GSQKRKCQEG GSWSGTEPSC QDSFMYDSPQ EVAEAFLSSL
760 770 780 790 800
TETIEGADAE DGHSPGEQQK RKIVLDPSGS MNIYLVLDGS DSIGSSNFTG
810 820 830 840 850
AKRCLTNLIE KVASYGVRPR YGLLTYATVP KVLVRVSDER SSDADWVTEK
860 870 880 890 900
LNQISYEDHK LKSGTNTKRA LQAVYSMMSW AGDAPPEGWN RTRHVIIIMT
910 920 930 940 950
DGLHNMGGNP VTVIQDIRAL LDIGRDPKNP REDYLDVYVF GVGPLVDSVN
960 970 980 990 1000
INALASKKDN EHHVFKVKDM EDLENVFYQM IDETKSLSLC GMVWEHKKGN
1010 1020 1030 1040 1050
DYHKQPWQAK ISVTRPLKGH ETCMGAVVSE YFVLTAAHCF MVDDQKHSIK
1060 1070 1080 1090 1100
VSVGGQRRDL EIEEVLFHPK YNINGKKAEG IPEFYDYDVA LVKLKNKLKY
1110 1120 1130 1140 1150
GQTLRPICLP CTEGTTRALR LPQTATCKQH KEQLLPVKDV KALFVSEQGK
1160 1170 1180 1190 1200
SLTRKEVYIK NGDKKASCER DATKAQGYEK VKDASEVVTP RFLCTGGVDP
1210 1220 1230 1240 1250
YADPNTCKGD SGGPLIVHKR SRFIQVGVIS WGVVDVCRDQ RRQQLVPSYA
1260 1270
RDFHINLFQV LPWLKDKLKD EDLGFL
Length:1,276
Mass (Da):142,325
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF29ABD24A5017E83
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CT025759 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000146299; ENSMUSP00000117677; ENSMUSG00000092511

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT025759 Genomic DNA No translation available.

3D structure databases

SMRiB8JJN0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117677

PTM databases

SwissPalmiB8JJN0

Proteomic databases

MaxQBiB8JJN0
PaxDbiB8JJN0
PeptideAtlasiB8JJN0
PRIDEiB8JJN0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000146299; ENSMUSP00000117677; ENSMUSG00000092511

Organism-specific databases

MGIiMGI:5142012 Gm20547

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000158605
HOGENOMiHOG000038034
InParanoidiB8JJN0
TreeFamiTF330194

Enzyme and pathway databases

ReactomeiR-MMU-173736 Alternative complement activation
R-MMU-174577 Activation of C3 and C5
R-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000092511 Expressed in 18 organ(s), highest expression level in liver
ExpressionAtlasiB8JJN0 baseline

Family and domain databases

CDDicd00033 CCP, 4 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR028341 Complement_B
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR46393:SF1 PTHR46393:SF1, 5 hits
PfamiView protein in Pfam
PF00084 Sushi, 3 hits
PF00089 Trypsin, 2 hits
PF00092 VWA, 2 hits
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SM00020 Tryp_SPc, 2 hits
SM00327 VWA, 2 hits
SUPFAMiSSF50494 SSF50494, 2 hits
SSF53300 SSF53300, 2 hits
SSF57535 SSF57535, 4 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 5 hits
PS50240 TRYPSIN_DOM, 2 hits
PS00134 TRYPSIN_HIS, 2 hits
PS00135 TRYPSIN_SER, 1 hit
PS50234 VWFA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB8JJN0_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B8JJN0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 8, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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