Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 83 (05 Jun 2019)
Sequence version 2 (10 Apr 2019)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Protein eyes shut homolog

Gene

eys

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to maintain the integrity of photoreceptor cells (PubMed:27737822, PubMed:28378834, PubMed:30052645). Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (PubMed:27737822).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSensory transduction, Vision
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein eyes shut homolog1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eys1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-130530-959 eys

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Progressive loss of cone photoreceptors in the retina from two months post-fertilization (mpf) onwards, with almost complete loss by 9 mpf. Rod photoreceptors also show signs of degeneration in older animals of 14 mpf. Photoreceptor degeneration is accompanied by increased apoptosis and mislocalization of outer segment proteins. At the ultrastructural level, morphology of the photoreceptor ciliary pocket is frequently abnormal with either complete collapse of the pocket, or presence of multiple membranous vesicles.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1163Missing in rmc101; impaired visual function from an early age. Light-induced locomotor activity is significantly reduced. Morphology of the photoreceptor outer segment is impaired. Localization of rho (rhodopsin) and gnat2 to the photoreceptor outer segment and photoreceptor F-actin morphology is also disrupted. 1 Publication1
Mutagenesisi1860Missing in del8; impaired visual function from an early age. Progressive degeneration of the retinal outer nuclear layer is detected from 2 months of age onwards, associated with increased apoptosis. Both rod and cone type photoreceptors show progressively reduced outer segment length. The photoreceptor outer segment proteins gnb3b and prph2 are mislocalized to the inner segment, and photoreceptor F-actin morphology is disrupted. Cone type photoreceptors also decline in number with age. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000044650324 – 2904Protein eyes shut homologSequence analysisAdd BLAST2881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi41N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi135N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi178 ↔ 193PROSITE-ProRule annotation
Disulfide bondi187 ↔ 204PROSITE-ProRule annotation
Disulfide bondi206 ↔ 215PROSITE-ProRule annotation
Disulfide bondi221 ↔ 232PROSITE-ProRule annotation
Disulfide bondi226 ↔ 247PROSITE-ProRule annotation
Disulfide bondi249 ↔ 258PROSITE-ProRule annotation
Glycosylationi257N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi266N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi267 ↔ 276PROSITE-ProRule annotation
Disulfide bondi271 ↔ 286PROSITE-ProRule annotation
Disulfide bondi288 ↔ 297PROSITE-ProRule annotation
Disulfide bondi304 ↔ 315PROSITE-ProRule annotation
Disulfide bondi309 ↔ 324PROSITE-ProRule annotation
Disulfide bondi326 ↔ 335PROSITE-ProRule annotation
Glycosylationi362N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi379 ↔ 390PROSITE-ProRule annotation
Disulfide bondi384 ↔ 399PROSITE-ProRule annotation
Disulfide bondi401 ↔ 410PROSITE-ProRule annotation
Disulfide bondi417 ↔ 430PROSITE-ProRule annotation
Disulfide bondi424 ↔ 439PROSITE-ProRule annotation
Disulfide bondi441 ↔ 450PROSITE-ProRule annotation
Disulfide bondi457 ↔ 470PROSITE-ProRule annotation
Disulfide bondi464 ↔ 484PROSITE-ProRule annotation
Disulfide bondi486 ↔ 495PROSITE-ProRule annotation
Disulfide bondi502 ↔ 513PROSITE-ProRule annotation
Disulfide bondi507 ↔ 522PROSITE-ProRule annotation
Disulfide bondi524 ↔ 533PROSITE-ProRule annotation
Glycosylationi544N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi568 ↔ 581PROSITE-ProRule annotation
Disulfide bondi575 ↔ 591PROSITE-ProRule annotation
Glycosylationi585N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi593 ↔ 602PROSITE-ProRule annotation
Disulfide bondi609 ↔ 620PROSITE-ProRule annotation
Disulfide bondi614 ↔ 629PROSITE-ProRule annotation
Disulfide bondi631 ↔ 640PROSITE-ProRule annotation
Disulfide bondi645 ↔ 656PROSITE-ProRule annotation
Disulfide bondi650 ↔ 665PROSITE-ProRule annotation
Glycosylationi662N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi667 ↔ 676PROSITE-ProRule annotation
Disulfide bondi683 ↔ 694PROSITE-ProRule annotation
Disulfide bondi688 ↔ 703PROSITE-ProRule annotation
Glycosylationi691N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi705 ↔ 714PROSITE-ProRule annotation
Disulfide bondi721 ↔ 732PROSITE-ProRule annotation
Disulfide bondi726 ↔ 741PROSITE-ProRule annotation
Disulfide bondi743 ↔ 752PROSITE-ProRule annotation
Disulfide bondi759 ↔ 772PROSITE-ProRule annotation
Disulfide bondi764 ↔ 781PROSITE-ProRule annotation
Disulfide bondi783 ↔ 792PROSITE-ProRule annotation
Disulfide bondi799 ↔ 810PROSITE-ProRule annotation
Disulfide bondi804 ↔ 819PROSITE-ProRule annotation
Disulfide bondi821 ↔ 830PROSITE-ProRule annotation
Disulfide bondi837 ↔ 848PROSITE-ProRule annotation
Disulfide bondi842 ↔ 857PROSITE-ProRule annotation
Disulfide bondi859 ↔ 868PROSITE-ProRule annotation
Disulfide bondi875 ↔ 886PROSITE-ProRule annotation
Disulfide bondi880 ↔ 895PROSITE-ProRule annotation
Disulfide bondi897 ↔ 906PROSITE-ProRule annotation
Disulfide bondi913 ↔ 924PROSITE-ProRule annotation
Disulfide bondi918 ↔ 933PROSITE-ProRule annotation
Glycosylationi921N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi935 ↔ 944PROSITE-ProRule annotation
Disulfide bondi951 ↔ 962PROSITE-ProRule annotation
Disulfide bondi956 ↔ 971PROSITE-ProRule annotation
Disulfide bondi973 ↔ 982PROSITE-ProRule annotation
Disulfide bondi987 ↔ 999PROSITE-ProRule annotation
Disulfide bondi993 ↔ 1014PROSITE-ProRule annotation
Disulfide bondi1016 ↔ 1025PROSITE-ProRule annotation
Disulfide bondi1032 ↔ 1042PROSITE-ProRule annotation
Disulfide bondi1037 ↔ 1051PROSITE-ProRule annotation
Disulfide bondi1053 ↔ 1062PROSITE-ProRule annotation
Disulfide bondi1069 ↔ 1080PROSITE-ProRule annotation
Disulfide bondi1074 ↔ 1089PROSITE-ProRule annotation
Glycosylationi1077N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1091 ↔ 1100PROSITE-ProRule annotation
Disulfide bondi1107 ↔ 1118PROSITE-ProRule annotation
Disulfide bondi1112 ↔ 1127PROSITE-ProRule annotation
Glycosylationi1115N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1129 ↔ 1138PROSITE-ProRule annotation
Disulfide bondi1145 ↔ 1156PROSITE-ProRule annotation
Disulfide bondi1150 ↔ 1167PROSITE-ProRule annotation
Disulfide bondi1169 ↔ 1178PROSITE-ProRule annotation
Disulfide bondi1185 ↔ 1198PROSITE-ProRule annotation
Disulfide bondi1192 ↔ 1208PROSITE-ProRule annotation
Glycosylationi1195N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1210 ↔ 1219PROSITE-ProRule annotation
Disulfide bondi1226 ↔ 1237PROSITE-ProRule annotation
Disulfide bondi1231 ↔ 1246PROSITE-ProRule annotation
Disulfide bondi1248 ↔ 1257PROSITE-ProRule annotation
Disulfide bondi1264 ↔ 1275PROSITE-ProRule annotation
Disulfide bondi1269 ↔ 1284PROSITE-ProRule annotation
Disulfide bondi1286 ↔ 1295PROSITE-ProRule annotation
Disulfide bondi1302 ↔ 1313PROSITE-ProRule annotation
Disulfide bondi1307 ↔ 1322PROSITE-ProRule annotation
Disulfide bondi1324 ↔ 1333PROSITE-ProRule annotation
Disulfide bondi1340 ↔ 1351PROSITE-ProRule annotation
Disulfide bondi1345 ↔ 1360PROSITE-ProRule annotation
Glycosylationi1348N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1362 ↔ 1371PROSITE-ProRule annotation
Disulfide bondi1378 ↔ 1388PROSITE-ProRule annotation
Disulfide bondi1383 ↔ 1397PROSITE-ProRule annotation
Disulfide bondi1399 ↔ 1408PROSITE-ProRule annotation
Disulfide bondi1415 ↔ 1426PROSITE-ProRule annotation
Disulfide bondi1420 ↔ 1435PROSITE-ProRule annotation
Disulfide bondi1437 ↔ 1446PROSITE-ProRule annotation
Disulfide bondi1453 ↔ 1469PROSITE-ProRule annotation
Glycosylationi1459N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1463 ↔ 1479PROSITE-ProRule annotation
Glycosylationi1476N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1481 ↔ 1490PROSITE-ProRule annotation
Disulfide bondi1497 ↔ 1508PROSITE-ProRule annotation
Disulfide bondi1502 ↔ 1517PROSITE-ProRule annotation
Disulfide bondi1519 ↔ 1528PROSITE-ProRule annotation
Disulfide bondi1535 ↔ 1545PROSITE-ProRule annotation
Disulfide bondi1540 ↔ 1556PROSITE-ProRule annotation
Disulfide bondi1558 ↔ 1567PROSITE-ProRule annotation
Glycosylationi1591N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1755N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1788N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1792 ↔ 1818PROSITE-ProRule annotation
Disulfide bondi1860 ↔ 1871PROSITE-ProRule annotation
Disulfide bondi1865 ↔ 1885PROSITE-ProRule annotation
Disulfide bondi1887 ↔ 1896PROSITE-ProRule annotation
Glycosylationi2025N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2064N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2071 ↔ 2102PROSITE-ProRule annotation
Disulfide bondi2102 ↔ 2113PROSITE-ProRule annotation
Disulfide bondi2107 ↔ 2122PROSITE-ProRule annotation
Disulfide bondi2124 ↔ 2133PROSITE-ProRule annotation
Disulfide bondi2138 ↔ 2149PROSITE-ProRule annotation
Disulfide bondi2143 ↔ 2159PROSITE-ProRule annotation
Disulfide bondi2161 ↔ 2170PROSITE-ProRule annotation
Glycosylationi2175N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2216N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2339 ↔ 2372PROSITE-ProRule annotation
Disulfide bondi2377 ↔ 2388PROSITE-ProRule annotation
Disulfide bondi2382 ↔ 2397PROSITE-ProRule annotation
Disulfide bondi2399 ↔ 2408PROSITE-ProRule annotation
Disulfide bondi2415 ↔ 2431PROSITE-ProRule annotation
Disulfide bondi2425 ↔ 2440PROSITE-ProRule annotation
Disulfide bondi2442 ↔ 2451PROSITE-ProRule annotation
Glycosylationi2465N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2528N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2570N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2642 ↔ 2653PROSITE-ProRule annotation
Disulfide bondi2647 ↔ 2663PROSITE-ProRule annotation
Disulfide bondi2665 ↔ 2674PROSITE-ProRule annotation
Disulfide bondi2680 ↔ 2691PROSITE-ProRule annotation
Disulfide bondi2685 ↔ 2702PROSITE-ProRule annotation
Glycosylationi2694N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2704 ↔ 2713PROSITE-ProRule annotation
Glycosylationi2750N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2816N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B8JI71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in retina where it localizes between the retinal pigment epithelium and the outer nuclear layer (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000079519 Expressed in 6 organ(s), highest expression level in mature ovarian follicle

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000098315

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini174 – 216EGF-like 1PROSITE-ProRule annotationAdd BLAST43
Domaini217 – 259EGF-like 2PROSITE-ProRule annotationAdd BLAST43
Domaini263 – 298EGF-like 3PROSITE-ProRule annotationAdd BLAST36
Domaini300 – 336EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini375 – 411EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini413 – 451EGF-like 6PROSITE-ProRule annotationAdd BLAST39
Domaini453 – 496EGF-like 7PROSITE-ProRule annotationAdd BLAST44
Domaini498 – 534EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini565 – 603EGF-like 9PROSITE-ProRule annotationAdd BLAST39
Domaini605 – 641EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini642 – 677EGF-like 11PROSITE-ProRule annotationAdd BLAST36
Domaini679 – 715EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini717 – 753EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini755 – 793EGF-like 14PROSITE-ProRule annotationAdd BLAST39
Domaini795 – 831EGF-like 15PROSITE-ProRule annotationAdd BLAST37
Domaini833 – 869EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini871 – 907EGF-like 17; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini909 – 945EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini947 – 983EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini984 – 1026EGF-like 20PROSITE-ProRule annotationAdd BLAST43
Domaini1028 – 1063EGF-like 21; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini1065 – 1101EGF-like 22PROSITE-ProRule annotationAdd BLAST37
Domaini1103 – 1139EGF-like 23; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1141 – 1179EGF-like 24PROSITE-ProRule annotationAdd BLAST39
Domaini1181 – 1220EGF-like 25PROSITE-ProRule annotationAdd BLAST40
Domaini1222 – 1258EGF-like 26; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1260 – 1296EGF-like 27; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1298 – 1334EGF-like 28; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1336 – 1372EGF-like 29; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1374 – 1409EGF-like 30; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini1411 – 1447EGF-like 31; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1449 – 1491EGF-like 32PROSITE-ProRule annotationAdd BLAST43
Domaini1493 – 1529EGF-like 33; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1531 – 1568EGF-like 34PROSITE-ProRule annotationAdd BLAST38
Domaini1640 – 1818Laminin G-like 1PROSITE-ProRule annotationAdd BLAST179
Domaini1856 – 1897EGF-like 35PROSITE-ProRule annotationAdd BLAST42
Domaini1902 – 2102Laminin G-like 2PROSITE-ProRule annotationAdd BLAST201
Domaini2098 – 2134EGF-like 36PROSITE-ProRule annotationAdd BLAST37
Domaini2135 – 2171EGF-like 37PROSITE-ProRule annotationAdd BLAST37
Domaini2182 – 2372Laminin G-like 3PROSITE-ProRule annotationAdd BLAST191
Domaini2373 – 2409EGF-like 38PROSITE-ProRule annotationAdd BLAST37
Domaini2411 – 2452EGF-like 39PROSITE-ProRule annotationAdd BLAST42
Domaini2459 – 2642Laminin G-like 4PROSITE-ProRule annotationAdd BLAST184
Domaini2638 – 2675EGF-like 40PROSITE-ProRule annotationAdd BLAST38
Domaini2676 – 2714EGF-like 41PROSITE-ProRule annotationAdd BLAST39
Domaini2719 – 2894Laminin G-like 5PROSITE-ProRule annotationAdd BLAST176

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EYS family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR67 Eukaryota
ENOG411061Z LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
NCENSID

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B8JI71

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 24 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 5 hits
PF02210 Laminin_G_2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 41 hits
SM00179 EGF_CA, 38 hits
SM00282 LamG, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 5 hits
SSF57184 SSF57184, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 21 hits
PS00022 EGF_1, 41 hits
PS01186 EGF_2, 32 hits
PS50026 EGF_3, 41 hits
PS01187 EGF_CA, 16 hits
PS50025 LAM_G_DOMAIN, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B8JI71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNPKLAIIV FLLSCVIYGP VYSQVTCRRA TSREWHTQPK NISVRWTLME
60 70 80 90 100
NTCSSLTQCW SSFAETNGHF WTTGPYHFPQ LCPLELQLGD LLFVSADGTL
110 120 130 140 150
EQHGVQLIKV SKEEFDKCAI LEPRKEQLVF ASSINGTLQV ESKWLMSGLN
160 170 180 190 200
YFTIINRGSS HLCRFGLRIA VLVKPQLCQS SPLLRLCSGK GECRTTLKDD
210 220 230 240 250
SFTCRCHKHF SGRYCENVDG CYEQPCLNGG TCLSEGSAYT DLPPYTCLCP
260 270 280 290 300
APFTGVNCSE IIGNQNCSKW CKEGACLKVS STSYRCECFT GYTGTYCERK
310 320 330 340 350
RLFCDSNPCR NDGRCEETAN GYVCTCPGGF TGLNCETTAE ADSYCKSSGC
360 370 380 390 400
QLDEACATDK LNATCICVDP ECLEQAEVCG TLPCLNGGIC VVPNGQYHCR
410 420 430 440 450
CRQGFSGKNC EEIIDFCKLL NINCLNEGLC LNRVGGYNCL CAPGWTGEFC
460 470 480 490 500
QYLENACLAY PNRCLNGATC ISMSQTTAPP HYMCTCLPGY TGPYCEAEVN
510 520 530 540 550
ECDSSPCQHQ GTCTDFVGYY KCTCPSGYTG IDCEIDINSC WLPNATCPPE
560 570 580 590 600
TLCVDLPGDQ LFKCHTPCPH YLQPCANGGH CVLHNITSYS CVCAPGWTGA
610 620 630 640 650
TCLVNINECV QHRCQNRATC VDEVGGYSCL CGHGYTGVHC ELDFCSGHQC
660 670 680 690 700
SEHAVCVDQQ HNYTCRCMLG YEGTLCELET DECKSAPCTN NATCIDLVAG
710 720 730 740 750
YQCLCAPGFK GRTCSESMNE CWSRPCNNGG SCIDLVNDYI CNCPLGFTGH
760 770 780 790 800
DCSMPATGCT SNPCNTKGTS MCEEQQDGFK CVCHHGYTGL FCETSINHCV
810 820 830 840 850
EGLCHHGSEC VDLTKGFMCE CLPGLRGRLC EVNIDDCLDK PCGALSICKD
860 870 880 890 900
GINAYDCFCA PGFVGNNCEI EVNECLSQPC QNGASCSDEL NSFSCLCLAG
910 920 930 940 950
TTGSLCEINI DECQSSPCMN NGTCLDLSDG FKCICPSGFS GPECSMDINE
960 970 980 990 1000
CVSYPCKNGG SCIDQPGNYY CRCLAPFKGL NCELLPCEAV NPCDNGAECV
1010 1020 1030 1040 1050
EEADLVLFPL GFQCRCRKGF TGPRCEVNID ECSSNPCLNG FCYDAVDGFY
1060 1070 1080 1090 1100
CLCNPGYAGV RCEQHINDCA SNMCENNSTC VDLHLSYNCL CLPGWEGEYC
1110 1120 1130 1140 1150
QRETNECLSN PCKNNATCTD LLNAYRCVCP QGWTGLDCDE DVKECSSSPC
1160 1170 1180 1190 1200
LNGAHCVESD TPGEFSCTCP PFFTGPLCEQ PYDPCELQRN PCLHNSTCRA
1210 1220 1230 1240 1250
QSDGTALCVC PVGFEGTRCE IDSDDCVSRP CQNRGICVDG VNSYSCFCEP
1260 1270 1280 1290 1300
GFSGLHCEED INECASNPCQ NQAVCQDLVN GFQCSCVPGY FGPHCNLDVN
1310 1320 1330 1340 1350
ECDSSPCLHE SVCINKPGGF ACVCSAGFSG KWCELNVDEC KSNPCRNNGS
1360 1370 1380 1390 1400
CIDGLNGYQC VCSRGFMGDH CERNTDECSS GPCVHGSCLD EIDAFSCQCE
1410 1420 1430 1440 1450
VGWTGHRCQI NINECEAHPC LNGGSCVDLL DKYACICADG FTGKNCDIDQ
1460 1470 1480 1490 1500
NVCLQTSLNF SLCFNGGTCV DGPGVNFTCS CRPGFMGDFC EVEMNECCSE
1510 1520 1530 1540 1550
PCFNGAICQD LINGYQCHCR PGWTGLHCED DINECLLQPC NQGMCIQNEP
1560 1570 1580 1590 1600
GHGYTCFCRP GFVGENCEYN YDDCLIQSCP ETFSCKDGIN NVSCVPVKTD
1610 1620 1630 1640 1650
TSSLPPISVV SWRSTDISTE LQPTFAPVEN LQHTEQPADA SFGGYSGNSF
1660 1670 1680 1690 1700
LEFGGFEVAV PISVTVRFQT ESMYGTLLYS ASAKRSVFFI KLYISNGILQ
1710 1720 1730 1740 1750
YDFLCNQKQG VQRINTAQWV ADGNEHVVIF RQCLFPCVAE VTVSGVRTVR
1760 1770 1780 1790 1800
SAPGNYTSAL RLQRTDHVFI GGLPRHRSPY KEAEPFHNYT GCIEIIEINK
1810 1820 1830 1840 1850
LRRFHMDHAI ARNNVDNCRS QWHHEPPTSS THSPTLLITV ETPPGEWVRV
1860 1870 1880 1890 1900
LSPTQPAPVC PQGICLNGGT CRPVSLPSGA SSFFCDCPLH FTGRLCEQDI
1910 1920 1930 1940 1950
TVFSPRFDGN SFLELPSLTS LFQSDTYFPS RSSEDKRILY LTMKSRTPHG
1960 1970 1980 1990 2000
SLLYCREQDL GERFLHVFLQ NARAVARLGC GAAHILTAVA AQNIRIDSLV
2010 2020 2030 2040 2050
AITVRYALPS QNNGQLCFIE IAADNGTANQ QQKYMDEPVS EVVFGPTFLG
2060 2070 2080 2090 2100
GFPSVLELHH NSGNVSGFIG CIRELQMGSK ELYVVGEAIR GQNIQNCDAA
2110 2120 2130 2140 2150
VCQHQPCRNG GTCISDAESW FCACPSLYSG KLCQFTACER NPCARGATCV
2160 2170 2180 2190 2200
PQTQLEAACL CPYGRQGLLC DEAINITRPK FSGLDEFGYS SYVAYPSIPS
2210 2220 2230 2240 2250
TGHFYEFHLK LTFANNASAL RNNLILFSGQ KGQGLSGDDF FALGVRNGRI
2260 2270 2280 2290 2300
VHKYNLGSGL ATIISDRLNP RINIHTVHFG RYLKTGWLKV NGQKRRTGTS
2310 2320 2330 2340 2350
PGPLMGLNTF SQLYIGGYEE YTPELLPPGS RFQNSFQGCI FDMLFRTRQD
2360 2370 2380 2390 2400
GKFHALGGPD IRPLSGRNVG QCGVNPCSLV FCHNGGTCVD SGSSVYCQCV
2410 2420 2430 2440 2450
FGWKGALCSE KVSFCDAEHI PPPFCARGST CVPLSDGYTC QCPLGSAGLH
2460 2470 2480 2490 2500
CQQAITISDP FFSGNQSSWM SFPPINIRHR THVQLQFQTL SPEGILFYTA
2510 2520 2530 2540 2550
QHLSTHSGDF LSISLSAGFL QLRYNLGNQT IVLQSPKELD VTGVRWHTVK
2560 2570 2580 2590 2600
AGREGNSGFL IVDGESVTRN SSEGSTTLDV GANIFIGGIS SLNTVSIDAV
2610 2620 2630 2640 2650
EKELVGFTGG IREVVVNGQE LELTETGALD GANVGDWDGT ACGYKVCKNG
2660 2670 2680 2690 2700
GHCHPSGDFS FTCICPSLWT GSRCQQSIQC LNNLCQHNSV CIHNSTSASY
2710 2720 2730 2740 2750
SCMCSLGWTG THCDREVTLK TIRFIGNSYL KYKDPKYNSR NLMHTEVSLN
2760 2770 2780 2790 2800
FSTSAGDGLI FWMGKAESED DDHLAVGLQD GYLKISVNLG ERTALPLVYQ
2810 2820 2830 2840 2850
NSFCCNYWNY LSITHNRTLI QVYVNEERVI FEDIDPFEQY VAVNYGGVIY
2860 2870 2880 2890 2900
LGGFELNRDV ASVTSGVFTK GFEGSIKDVF LYQDTKQLQF LQTCEGFNVY

QGEE
Length:2,904
Mass (Da):317,343
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8A6BB9E89AA6108
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A493VTS8A0A493VTS8_DANRE
Protein eyes shut homolog
eys
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX005106 Genomic DNA No translation available.
BX323836 Genomic DNA No translation available.
CR456624 Genomic DNA No translation available.
CU570696 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_009305788.1, XM_009307513.2
XP_009305789.1, XM_009307514.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
557044

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005106 Genomic DNA No translation available.
BX323836 Genomic DNA No translation available.
CR456624 Genomic DNA No translation available.
CU570696 Genomic DNA No translation available.
RefSeqiXP_009305788.1, XM_009307513.2
XP_009305789.1, XM_009307514.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000098315

Proteomic databases

PaxDbiB8JI71

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi557044

Organism-specific databases

ZFINiZDB-GENE-130530-959 eys

Phylogenomic databases

eggNOGiENOG410IR67 Eukaryota
ENOG411061Z LUCA
OMAiNCENSID
PhylomeDBiB8JI71

Gene expression databases

BgeeiENSDARG00000079519 Expressed in 6 organ(s), highest expression level in mature ovarian follicle

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00008 EGF, 24 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 5 hits
PF02210 Laminin_G_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 41 hits
SM00179 EGF_CA, 38 hits
SM00282 LamG, 5 hits
SUPFAMiSSF49899 SSF49899, 5 hits
SSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 21 hits
PS00022 EGF_1, 41 hits
PS01186 EGF_2, 32 hits
PS50026 EGF_3, 41 hits
PS01187 EGF_CA, 16 hits
PS50025 LAM_G_DOMAIN, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEYS_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B8JI71
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 10, 2019
Last sequence update: April 10, 2019
Last modified: June 5, 2019
This is version 83 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again