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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15SubstrateUniRule annotation1
Binding sitei42Substrate; via amide nitrogenUniRule annotation1
Binding sitei72Pyridoxal phosphateUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132Pyridoxal phosphateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei186Pyridoxal phosphateUniRule annotation1
Binding sitei186SubstrateUniRule annotation1
Binding sitei217Pyridoxal phosphateUniRule annotation1
Binding sitei256Pyridoxal phosphateUniRule annotation1
Binding sitei291Pyridoxal phosphateUniRule annotation1
Binding sitei291SubstrateUniRule annotation1
Binding sitei387SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciDDES525146:G1GUN-1214-MONOMER
UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:Ddes_1151
OrganismiDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Taxonomic identifieri525146 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002598 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001868641 – 408LL-diaminopimelate aminotransferaseAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB8IZX8

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi525146.Ddes_1151

Structurei

3D structure databases

ProteinModelPortaliB8IZX8
SMRiB8IZX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 109Pyridoxal phosphate bindingUniRule annotation2
Regioni245 – 247Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QSS Bacteria
COG0436 LUCA
HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit

Sequencei

Sequence statusi: Complete.

B8IZX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATVNSNFLK LQSNYLFADI ARKVTAFKNA NPDRRVISLG IGDVTRPLPP
60 70 80 90 100
AVIQALHKAV DEMGDATLFR GYGPEQGYAF LRDVIMQYDY KVRGVTLAPD
110 120 130 140 150
EIFVSDGAKP DVGNFQELFA QDSIVAVTDP VYPVYVDSNV MAGRSGEIKD
160 170 180 190 200
SQWSRIVYLP CIKENDFVPD FPAVRPDMIY LCYPNNPTGT VLSRAALQGW
210 220 230 240 250
VEYARREGCV ILYDSAYEAF ITEADIPHSI YEIDGAEEVA VEFRSFSKTA
260 270 280 290 300
GFTGLRCAYT VVPKALRISD GKSGSVSLNA LWNRRQCTKY NGCPYIVQRA
310 320 330 340 350
AEAVYSERGQ SEIMGIIAGY QRNAAMLRTA ASEMGFAVYG GVNAPYIWLR
360 370 380 390 400
VPDNTDSWGF FDRLLQQAGL VCTPGAGFGI SGEGYVRLTA FGSPEDTEEA

IHRLRSLC
Length:408
Mass (Da):45,013
Last modified:March 3, 2009 - v1
Checksum:i7E5492E7577392BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001358 Genomic DNA Translation: ACL49055.1
RefSeqiWP_012624780.1, NC_011883.1

Genome annotation databases

EnsemblBacteriaiACL49055; ACL49055; Ddes_1151
KEGGidds:Ddes_1151

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001358 Genomic DNA Translation: ACL49055.1
RefSeqiWP_012624780.1, NC_011883.1

3D structure databases

ProteinModelPortaliB8IZX8
SMRiB8IZX8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi525146.Ddes_1151

Proteomic databases

PRIDEiB8IZX8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL49055; ACL49055; Ddes_1151
KEGGidds:Ddes_1151

Phylogenomic databases

eggNOGiENOG4107QSS Bacteria
COG0436 LUCA
HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

BioCyciDDES525146:G1GUN-1214-MONOMER

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_DESDA
AccessioniPrimary (citable) accession number: B8IZX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 10, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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