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Protein

60 kDa chaperonin

Gene

groL

Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCEL394503:G1GUL-390-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
Ordered Locus Names:Ccel_0392
OrganismiClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Taxonomic identifieri394503 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000001349 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001470251 – 54360 kDa chaperoninAdd BLAST543

Proteomic databases

PRIDEiB8I5W0

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi394503.Ccel_0392

Structurei

3D structure databases

ProteinModelPortaliB8I5W0
SMRiB8I5W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9 Bacteria
COG0459 LUCA
HOGENOMiHOG000076290
KOiK04077
OMAiTDTDKME
OrthoDBiPOG091H00E7

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

B8I5W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEIKFGEE ARRSLEKGVN QLADTVKVTL GPKGRNVVLD KKFGSPLITN
60 70 80 90 100
DGVTIAKEVE LEDKFENMGA QLVKEVATKT NDVAGDGTTT ATLLAQAIIR
110 120 130 140 150
EGMKNVAAGA NPMILKKGLQ KAVDTAVAGI KENSRKVKGK EDIARVATIS
160 170 180 190 200
ANEELIGTLI ADAMEKVTND GVITVEESKT MGTNLEVVEG MQFDRGYLSA
210 220 230 240 250
YMVTDTDKME AVLDDPYILI TDKKLTNIQD LLPILEEIVK QGKKLLIIAE
260 270 280 290 300
DIEGEALTTL ILNKLRGTFV CVAVKAPGFG DRRKAMLQDI AILTGGEVIT
310 320 330 340 350
EELGLDLKET QITQLGKARQ VIVQKENTII VDGNGSAEDI KSRINSIKTQ
360 370 380 390 400
IEDTTSDFDR EKLQERLAKL SGGVAVIQVG AATETEMKEK KLRIEDALAA
410 420 430 440 450
TRAAVEEGIV AGGGTAFINV IPEVAKLLES TSGDEKTGVQ IILRALEEPV
460 470 480 490 500
RQIAENAGLE GSVIVEKIKT SEKGMGFDAL NEKYIDMIEG GIVDPAKVTR
510 520 530 540
SALQNAVSVA AMVLTTESVV ADKPEPEAPA VPAGMPGGMG GMY
Length:543
Mass (Da):58,017
Last modified:March 3, 2009 - v1
Checksum:i237B54F11392E365
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001348 Genomic DNA Translation: ACL74777.1
RefSeqiWP_012634840.1, NC_011898.1

Genome annotation databases

EnsemblBacteriaiACL74777; ACL74777; Ccel_0392
KEGGicce:Ccel_0392

Similar proteinsi

Entry informationi

Entry nameiCH60_CLOCE
AccessioniPrimary (citable) accession number: B8I5W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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