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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCCEL394503:G1GUL-1171-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Ccel_1147
OrganismiClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Taxonomic identifieri394503 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000001349 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalUniRule annotationAdd BLAST21
Transmembranei48 – 68HelicalUniRule annotationAdd BLAST21
Transmembranei92 – 112HelicalUniRule annotationAdd BLAST21
Transmembranei118 – 138HelicalUniRule annotationAdd BLAST21
Transmembranei154 – 174HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 212HelicalUniRule annotationAdd BLAST21
Transmembranei226 – 246HelicalUniRule annotationAdd BLAST21
Transmembranei261 – 281HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001488071 – 281Undecaprenyl-diphosphataseAdd BLAST281

Proteomic databases

PRIDEiB8I004

Interactioni

Protein-protein interaction databases

STRINGi394503.Ccel_1147

Structurei

3D structure databases

SMRiB8I004
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiVFKDRIL
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit

Sequencei

Sequence statusi: Complete.

B8I004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLLFVLKS IVLGIVEGVT EFLPISSTGH LIIFENIMGF KSASPNYVKM
60 70 80 90 100
YTYVIQLGAI MAVVLLYWKK IKETVINFFP GKVGYEKSGF KFWFMIFIAC
110 120 130 140 150
IPGAAVKLLL DAPVEKYLMT PVSVAIVLIL GGLWMIYAEK KFRNNNLGKQ
160 170 180 190 200
KLSVTPKQAL IIGAFQCLAI IPGMSRSAST IIGGWVAGLS TVVAAEFSFF
210 220 230 240 250
LAIPVMFGYS LLEIIRIGGL TSLPAAELIS LVVGFIVAFI VAVAVISQFI
260 270 280
SYLKRKPLKS FAIYRMIFAV IVLIAGFMGF F
Length:281
Mass (Da):30,843
Last modified:March 3, 2009 - v1
Checksum:i0107AFF3EE196C14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001348 Genomic DNA Translation: ACL75504.1
RefSeqiWP_015924659.1, NC_011898.1

Genome annotation databases

EnsemblBacteriaiACL75504; ACL75504; Ccel_1147
KEGGicce:Ccel_1147

Similar proteinsi

Entry informationi

Entry nameiUPPP_CLOCE
AccessioniPrimary (citable) accession number: B8I004
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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