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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Achl_1568
OrganismiPseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePseudarthrobacter
Proteomesi
  • UP000002505 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalUniRule annotationAdd BLAST21
Transmembranei55 – 75HelicalUniRule annotationAdd BLAST21
Transmembranei86 – 106HelicalUniRule annotationAdd BLAST21
Transmembranei120 – 140HelicalUniRule annotationAdd BLAST21
Transmembranei163 – 183HelicalUniRule annotationAdd BLAST21
Transmembranei196 – 216HelicalUniRule annotationAdd BLAST21
Transmembranei239 – 259HelicalUniRule annotationAdd BLAST21
Transmembranei266 – 286HelicalUniRule annotationAdd BLAST21
Transmembranei291 – 311HelicalUniRule annotationAdd BLAST21
Transmembranei348 – 368HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001171591 – 369Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST369

Interactioni

Protein-protein interaction databases

STRINGi452863.Achl_1568

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8HGW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIALLIGAGL ALLCALVGTP LFIRLLVRRG YGQFIRDDGP TSHHTKRGTP
60 70 80 90 100
TMGGTVVVAA VLLSYGLTHL IMFLMNPDSP GPSASALILL FLMVGMGLVG
110 120 130 140 150
FLDDFIKISR QRSLGLNAKA KLILQAAVGV IFAVLALNFP DESGLAPAST
160 170 180 190 200
KISLVRDLPW LDLAFGGTVL GAILFVVWSN LIVTAATNGV NLTDGLDGLA
210 220 230 240 250
AGASVMVFGA YTLMGIWQSN QACGSPREAG SGCYSVRDPL DLALLAAIMS
260 270 280 290 300
AALVGFLWWN TSPAKIFMGD TGSLAIGGAI AGFAILSRTE LLLGIIGGLF
310 320 330 340 350
VLITLSVIIQ VGYFKATGGK RVFKMAPLQH HFELKGWAEV TVVVRFWILG
360
GLFVAVGLGI FYAEWVVLL
Length:369
Mass (Da):38,849
Last modified:March 3, 2009 - v1
Checksum:i4F15EEC77AF8C86B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA Translation: ACL39556.1
RefSeqiWP_015936776.1, NC_011886.1

Genome annotation databases

EnsemblBacteriaiACL39556; ACL39556; Achl_1568
KEGGiach:Achl_1568

Similar proteinsi

Entry informationi

Entry nameiMRAY_PSECP
AccessioniPrimary (citable) accession number: B8HGW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: July 18, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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