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Protein

DNA ligase

Gene

lig

Organism
Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei245ATPUniRule annotation1
Active sitei247N6-AMP-lysine intermediateUniRule annotation1
Binding sitei252ATPUniRule annotation1
Binding sitei267ATPUniRule annotation1
Binding sitei296ATPUniRule annotation1
Binding sitei336ATPUniRule annotation1
Binding sitei408ATPUniRule annotation1
Binding sitei414ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPAL521011:G1GUJ-2843-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mpal_2781
OrganismiMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Taxonomic identifieri521011 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanosphaerula
Proteomesi
  • UP000002457 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001347281 – 556DNA ligaseAdd BLAST556

Proteomic databases

PRIDEiB8GGB8

Interactioni

Protein-protein interaction databases

STRINGi521011.Mpal_2781

Structurei

3D structure databases

ProteinModelPortaliB8GGB8
SMRiB8GGB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

B8GGB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFSIFAQTC AALEAQNGRL EMKHAISVIL PSLSGEDLPI FIRFLMGKIF
60 70 80 90 100
PDWSPQKLGI GPNLLYEAVA YVAGTKKTAL VDLINRTGDA GLAIEQFLAT
110 120 130 140 150
KEQTAFFTED PSLAEVYAAC TRIAASAGGR SQRERLLVLR QLFGNVSPFE
160 170 180 190 200
ARYLARLILG ELRIGIGEGT VRDAIAEAYT VEPAQVEHAM QALNDLGEVA
210 220 230 240 250
LRAREGEEGL IHLSIAPFRP VKMMLAQAGT TIPEMLAAHG EVAVEFKYDG
260 270 280 290 300
TRFQFHKEGK TCRIYSRKLE EVTDAVPEVG EALLGATDHD VILDGEVIAI
310 320 330 340 350
GADGRPLPFQ TVLRRFRRKH GIAAAREAIT LVPRVFDILY RDGETLIDLP
360 370 380 390 400
FQSRRAILSA TIGPEYLAPQ QVLSSAEAVD LLYLEAMAEG HEGVMLKDLL
410 420 430 440 450
SLYSPGVRGK HWVKIKPEVE TLDLVVIGAE WGEGRRARTF GSFLLACLDQ
460 470 480 490 500
GVFRAVSKVA TGISDEQLQE LYTLFKDQVI AESGNTVTFE PTVIFEVGYA
510 520 530 540 550
EIQKSPSYES GYALRFPRFV QVRDDKAVEE IETLESLTTR YLAQKTQANG

QPEFTL
Length:556
Mass (Da):61,297
Last modified:March 3, 2009 - v1
Checksum:i6665DC65DB81AE57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001338 Genomic DNA Translation: ACL18036.1
RefSeqiWP_012619355.1, NC_011832.1

Genome annotation databases

EnsemblBacteriaiACL18036; ACL18036; Mpal_2781
GeneIDi7272662
KEGGimpl:Mpal_2781

Similar proteinsi

Entry informationi

Entry nameiDNLI_METPE
AccessioniPrimary (citable) accession number: B8GGB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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