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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Methylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei607For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

BioCyciMSIL395965:G1GUA-729-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:Msil_0708Imported
OrganismiMethylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2)Imported
Taxonomic identifieri395965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBeijerinckiaceaeMethylocella
Proteomesi
  • UP000002257 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi395965.Msil_0708

Structurei

3D structure databases

ProteinModelPortaliB8EP91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 221Glutamine amidotransferase type-2InterPro annotationAdd BLAST220
Domaini282 – 427SISInterPro annotationAdd BLAST146
Domaini460 – 602SISInterPro annotationAdd BLAST143

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili37 – 57Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8EP91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIVGVLGL GPVQNLIVEA LKRLEYRGYD SAGIACLENG KLSRRRASGK
60 70 80 90 100
LRNLEERLAK EPLAGSTGIG HTRWATHGKA TENNAHPHAT DKIAVVHNGI
110 120 130 140 150
IENFRELREE LRAKGRHFAS QTDSEVIAHL VTQSLDEGLS PIEAVAASLP
160 170 180 190 200
RLKGAFAFAM IFAGEDNLLI GASQGAPLAV GFGEDDRAGE MFLGSDALAL
210 220 230 240 250
APFTQQVAYL EDGDMVVLTH DSASFRDASG LPVERRRIRT QASAFLIDKG
260 270 280 290 300
NHRHFMAKEI HEQPEVVGRT LGHYLDMSSG HVALPFELPV DPATLSRLTI
310 320 330 340 350
CGCGTAYFSA LMAKYWFERF ARLPVDVEIA SEFRYRDPPL DPSGLTIVVS
360 370 380 390 400
QSGETADTLA ALRCAKGKGQ KILAIVNVAS STMSREADVV APTLAGPEIG
410 420 430 440 450
VASTKAFTCQ LAVFAALALA FGRARGVLGA KEEARLIGEL MAVPGLMAQA
460 470 480 490 500
LKCESAIEGL AREIGKVRDV LYLGRGAAYP LALEGALKLK EISYIHAEGY
510 520 530 540 550
AAGELKHGPI ALIDGDMPVI VIAPKDAVLE KTISNMQEVA ARGGRLILIG
560 570 580 590 600
DENLARDFAG EAEASIIMPE FPADFAGMVY AIPIQLIAYH TAVVMGKDAD
610
QPRNLAKSVT VE
Length:612
Mass (Da):65,404
Last modified:March 3, 2009 - v1
Checksum:iC2CDB610EC4D8BD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001280 Genomic DNA Translation: ACK49679.1
RefSeqiWP_012589749.1, NC_011666.1

Genome annotation databases

EnsemblBacteriaiACK49679; ACK49679; Msil_0708
KEGGimsl:Msil_0708

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001280 Genomic DNA Translation: ACK49679.1
RefSeqiWP_012589749.1, NC_011666.1

3D structure databases

ProteinModelPortaliB8EP91
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi395965.Msil_0708

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK49679; ACK49679; Msil_0708
KEGGimsl:Msil_0708

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Enzyme and pathway databases

BioCyciMSIL395965:G1GUA-729-MONOMER

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiB8EP91_METSB
AccessioniPrimary (citable) accession number: B8EP91
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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