Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Argininosuccinate synthase

Gene

argG

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87CitrullineUniRule annotation1
Binding sitei117ATP; via amide nitrogenUniRule annotation1
Binding sitei119AspartateUniRule annotation1
Binding sitei123AspartateUniRule annotation1
Binding sitei123CitrullineUniRule annotation1
Binding sitei124AspartateUniRule annotation1
Binding sitei127CitrullineUniRule annotation1
Binding sitei175CitrullineUniRule annotation1
Binding sitei184CitrullineUniRule annotation1
Binding sitei257CitrullineUniRule annotation1
Binding sitei269CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 17ATPUniRule annotation9

GO - Molecular functioni

  • argininosuccinate synthase activity Source: GO_Central
  • ATP binding Source: UniProtKB-UniRule

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDTUR515635:G1GU5-1839-MONOMER
UniPathwayi
UPA00068;UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Dtur_1787
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
Proteomesi
  • UP000007719 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001918931 – 397Argininosuccinate synthaseAdd BLAST397

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi515635.Dtur_1787

Structurei

3D structure databases

ProteinModelPortaliB8E0N9
SMRiB8E0N9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
InParanoidiB8E0N9
KOiK01940
OMAiPAREWGM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit

Sequencei

Sequence statusi: Complete.

B8E0N9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEREKVVLAY SGGLDTSVAI KWLMQKYSLD VITLTVDIGQ GIDLNEIKNK
60 70 80 90 100
AENLGVEKAY VLDLREEFIK DYIIPAIKSN AMYERVYPLA TALSRPLIAK
110 120 130 140 150
YLVKVAKENG AKYVAHGCTG KGNDQVRIDL GVKALAPDLE IIAPVREWNF
160 170 180 190 200
SREEEIEYAI ENNIPIPVSR KNPYSIDENL WGRSIEGGIL EDPWQEPPED
210 220 230 240 250
IYLWTKLENK EPSYIEITFE KGIPVKLNGV EKDLVGLIEE LNKIAGSYGI
260 270 280 290 300
GRIDHIENRL VGIKSREIYE APAALVIIKA HEALEDLVLP RELAHFKRML
310 320 330 340 350
EDKYAELVYY GLWFDPFREA LQAFMDKTQE RVTGKVKIKL IPWSFSIVGR
360 370 380 390
DSPYSLYDHS LATYDKGSTF STESAVGFIK LFGLQNYLYA LKGGKNA
Length:397
Mass (Da):44,986
Last modified:March 3, 2009 - v1
Checksum:i2883E3E95625C03B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA Translation: ACK43059.1
RefSeqiWP_012584133.1, NC_011661.1
YP_002353673.1, NC_011661.1

Genome annotation databases

EnsemblBacteriaiACK43059; ACK43059; Dtur_1787
GeneIDi7082966
KEGGidtu:Dtur_1787
PATRICifig|515635.4.peg.1839

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA Translation: ACK43059.1
RefSeqiWP_012584133.1, NC_011661.1
YP_002353673.1, NC_011661.1

3D structure databases

ProteinModelPortaliB8E0N9
SMRiB8E0N9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi515635.Dtur_1787

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK43059; ACK43059; Dtur_1787
GeneIDi7082966
KEGGidtu:Dtur_1787
PATRICifig|515635.4.peg.1839

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
InParanoidiB8E0N9
KOiK01940
OMAiPAREWGM
OrthoDBiPOG091H01U0

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

BioCyciDTUR515635:G1GU5-1839-MONOMER

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASSY_DICTD
AccessioniPrimary (citable) accession number: B8E0N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again