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Protein

Acetate kinase

Gene

ackA

Organism
Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (DvMF_1864)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei95SubstrateUniRule annotation1
Active sitei152Proton donor/acceptorUniRule annotation1
Sitei184Transition state stabilizerUniRule annotation1
Sitei245Transition state stabilizerUniRule annotation1
Metal bindingi388MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi212 – 216ATPUniRule annotation5
Nucleotide bindingi286 – 288ATPUniRule annotation3
Nucleotide bindingi334 – 338ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL883:G1GTY-1898-MONOMER
UniPathwayiUPA00340; UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:DvMF_1865
OrganismiDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Taxonomic identifieri883 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000001361 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001163891 – 404Acetate kinaseAdd BLAST404

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi883.DvMF_1865

Structurei

3D structure databases

ProteinModelPortaliB8DMG5
SMRiB8DMG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiHOG000288398
KOiK00925
OMAiWKALTGT
OrthoDBiPOG091H02K4

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8DMG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLVINSGS SSIKYQLIDM TTEKALCSGL VERIGEGMGK LTHKIKPDTD
60 70 80 90 100
AEEKIVLEQA FANHVEGMKK VVDLITDADK GVIADKGEIY AVGHRVLLGG
110 120 130 140 150
EEIKQSVKID EWAKGIIRDY IPLGPLHNPA NLAGIEVAEE LFPHAPSVGV
160 170 180 190 200
FDTEFHQTMP KKAYLYPLPY DLYKTLRIRR YGFHGTSHRY ITKKTAEFLG
210 220 230 240 250
KPLDELNIIT CHLGNGCSMA AVKNGRCVDT TMGITPLEGL MMGTRCGDID
260 270 280 290 300
PALVPFLMEK KGWSGAEIDT VMNKQSGLKG ICGMNDMRDI HAAREKGDEM
310 320 330 340 350
AELAFQMFVY RIRKYIGSFA VVVGKLDAIV FTAGIGENDD LVRAAVCKDM
360 370 380 390 400
DILGIDIDEA VNAKRSGQAR HIGKPGQRVP VLVVPTNEEL EIAQTTVAVL

NGKN
Length:404
Mass (Da):44,241
Last modified:March 3, 2009 - v1
Checksum:i99F0E8AA83E2C42E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001197 Genomic DNA Translation: ACL08809.1
RefSeqiWP_012612984.1, NC_011769.1

Genome annotation databases

EnsemblBacteriaiACL08809; ACL08809; DvMF_1865
KEGGidvm:DvMF_1865

Similar proteinsi

Entry informationi

Entry nameiACKA_DESVM
AccessioniPrimary (citable) accession number: B8DMG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: February 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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