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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei602For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

BioCyciDVUL883:G1GTY-1742-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:DvMF_1706Imported
OrganismiDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637)Imported
Taxonomic identifieri883 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000001361 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi883.DvMF_1706

Structurei

3D structure databases

ProteinModelPortaliB8DM08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 220Glutamine amidotransferase type-2InterPro annotationAdd BLAST219
Domaini283 – 425SISInterPro annotationAdd BLAST143
Domaini459 – 597SISInterPro annotationAdd BLAST139

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8DM08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIIGYAGH RPAVPLIIEG LRRLEYRGYD SAGVAFVQNR ELITVRAEGK
60 70 80 90 100
LSALDEKLAS CPNTVATTGM GHTRWATHGI PVERNAHPHK SNDGGLAIVH
110 120 130 140 150
NGIIENYAEL KADLAAKGYV FHSETDTEVL ANLISEGRKH NATMLDAFAW
160 170 180 190 200
ALRQAHGAYA VALTTPEEPE VLYAARLSAP LILGVGTGEN FVASDIPAFL
210 220 230 240 250
PYTRDVVFLE DGELVRIDAN SWKVMRIADL SPVEKAVNHI QWDMQAAQKG
260 270 280 290 300
GYKHFMLKEI FEQPKVITDC LAGRVDWNRM EVTLPELAAL PVPKRLHIVA
310 320 330 340 350
CGTSYHAGMW GKHLLESWAR VPVNVEIASE FRYRDIILDP ADMVLVISQS
360 370 380 390 400
GETADTLAAL RIAREHGVKV AGLCNVVGSS IAREADAVIY TQAGPEISVA
410 420 430 440 450
STKAMCSQMV LLTLMALHWG RNTGALSETV RANVLQTLRK LPGQLETVLP
460 470 480 490 500
AMRDEAQVLA RTYSKAKSFF YLGRGHCFPL ALEGALKLKE ISYIHAEGYA
510 520 530 540 550
SGEMKHGPIA LIDPDFPTFA LALNDELFPK VKSNIEEVQA RRGKIIALTN
560 570 580 590 600
PGVELKVDHP WSIPDAWGPM AAFLVLPALQ LFSYEAADYL GKDVDQPRNL

AKSVTVE
Length:607
Mass (Da):66,416
Last modified:March 3, 2009 - v1
Checksum:i00BE87C0B5312578
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001197 Genomic DNA Translation: ACL08652.1
RefSeqiWP_012612828.1, NC_011769.1

Genome annotation databases

EnsemblBacteriaiACL08652; ACL08652; DvMF_1706
KEGGidvm:DvMF_1706

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001197 Genomic DNA Translation: ACL08652.1
RefSeqiWP_012612828.1, NC_011769.1

3D structure databases

ProteinModelPortaliB8DM08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi883.DvMF_1706

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL08652; ACL08652; DvMF_1706
KEGGidvm:DvMF_1706

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Enzyme and pathway databases

BioCyciDVUL883:G1GTY-1742-MONOMER

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiB8DM08_DESVM
AccessioniPrimary (citable) accession number: B8DM08
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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