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Protein

Cardiolipin synthase

Gene

cls

Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei222UniRule annotation1
Active sitei224UniRule annotation1
Active sitei229UniRule annotation1
Active sitei400UniRule annotation1
Active sitei402UniRule annotation1
Active sitei407UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthaseUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:cls
Ordered Locus Names:LMHCC_0097
OrganismiListeria monocytogenes serotype 4a (strain HCC23)
Taxonomic identifieri552536 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Transmembranei34 – 54HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001242691 – 482Cardiolipin synthaseAdd BLAST482

Structurei

3D structure databases

SMRiB8DBK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 244PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini395 – 422PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000077402
KOiK06131
OMAiGGHNVGD

Family and domain databases

HAMAPiMF_01916 Cardiolipin_synth_Cls, 1 hit
InterProiView protein in InterPro
IPR030874 Cardiolipin_synth_Firmi
IPR022924 Cardiolipin_synthase
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

B8DBK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLAYLLVI LLILNVFFAA VTVFLERRDT SATWAWLLVL TFVPIFGFII
60 70 80 90 100
YLIFGRKLSG KKIFDWKGQE KIGIQESTAN QIEMIRQKEF PFSDPNVKKH
110 120 130 140 150
RDLIYLLLVN DGAILTQDNE VELFVDGHEK FDALIADIEN AKDHIHLIYY
160 170 180 190 200
IFHSDELGNR LMRVLERKAA EGLNVKIIYD AMGSRTTKKS FFRTFQKNGG
210 220 230 240 250
LVRPFFPSKL PLINFRLNYR NHRKLAIIDG DVGYIGGFNI GDEYLGASKK
260 270 280 290 300
FGYWRDTHLR VHGKAVYAMQ TRFIMDWNSA SSTHKIDYKA RYFPTFHGKG
310 320 330 340 350
HTSMQIVSSG PDSEWQQIKN GYIKMINAAK KTIYLQSPYF IPDASLLEAI
360 370 380 390 400
KIAALSGVDV RVMIPNKPDH AFVYRATTNY AGELMETGAK IFIYDNGFIH
410 420 430 440 450
AKTLVVDGEI ASVGTANMDF RSFRLNFEVN AFIYEKQMVQ KLEDAFLEDI
460 470 480
LKSYQLTPEL YAKRSLWIKF KEAVSRLLSP IL
Length:482
Mass (Da):55,348
Last modified:March 3, 2009 - v1
Checksum:iE40E2ACED650756A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001175 Genomic DNA Translation: ACK38459.1
RefSeqiWP_003729224.1, NC_011660.1

Genome annotation databases

EnsemblBacteriaiACK38459; ACK38459; LMHCC_0097
KEGGilmh:LMHCC_0097

Similar proteinsi

Entry informationi

Entry nameiCLS_LISMH
AccessioniPrimary (citable) accession number: B8DBK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: July 18, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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