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Protein

Inositol-tetrakisphosphate 1-kinase 3

Gene

ITPK3

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and participates in phytic acid biosynthesis in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.By similarity

Catalytic activityi

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.Curated
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.Curated
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.Curated

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei561D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei981D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei133ATPBy similarity1
Binding sitei183ATPBy similarity1
Binding sitei1901D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei2221D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei237ATPBy similarity1
Binding sitei262ATPBy similarity1
Metal bindingi302Magnesium 1By similarity1
Metal bindingi317Magnesium 1By similarity1
Metal bindingi317Magnesium 2By similarity1
Metal bindingi319Magnesium 2By similarity1
Binding sitei3191D-myo-inositol 1,3,4-trisphosphateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi211 – 222ATPBy similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-1855167 Synthesis of pyrophosphates in the cytosol
R-OSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-OSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-tetrakisphosphate 1-kinase 3Curated (EC:2.7.1.134Curated)
Alternative name(s):
Inositol 1,3,4-trisphosphate 5/6-kinase 3Curated (EC:2.7.1.159Curated)
Short name:
Inositol-triphosphate 5/6-kinase 3Curated
Short name:
Ins(1,3,4)P(3) 5/6-kinase 3Curated
Short name:
OsITP5/6K-3Curated
Short name:
OsITPK3Curated
Gene namesi
Name:ITPK3
ORF Names:OsI_13362Imported
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004318741 – 357Inositol-tetrakisphosphate 1-kinase 3Add BLAST357

Expressioni

Gene expression databases

ExpressionAtlasiB8AR41 differential

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi39946.BGIOSGA013495-PA

Structurei

3D structure databases

SMRiB8AR41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ITPK1 family.Curated

Phylogenomic databases

eggNOGiENOG410IHA6 Eukaryota
ENOG4110KIK LUCA
HOGENOMiHOG000220790
OMAiDLTDCHG
OrthoDBiEOG09360GWF

Family and domain databases

InterProiView protein in InterPro
IPR008656 Inositol_tetrakis-P_1-kinase
PANTHERiPTHR14217 PTHR14217, 1 hit
PfamiView protein in Pfam
PF05770 Ins134_P3_kin, 1 hit
PIRSFiPIRSF038186 ITPK, 1 hit

Sequencei

Sequence statusi: Complete.

B8AR41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSGGRVGGG EGEAGEAAEV AVAMVDNEEE VAQAQAPPAA AVAARELVVG
60 70 80 90 100
YALTSKKAKS FLQPKLRGLA RKKGILFVAI DQKRPLSDQG PFDIVLHKLT
110 120 130 140 150
GREWQQLLEE YREEHPEVTV LDPPGAIEHL LNRQSMLQEV SELDLSDCHG
160 170 180 190 200
RVGVPKQLFV NTDPSSIPAA VMRAGLSLPL VAKPLVAKSH ELSLAYDPIS
210 220 230 240 250
LTKLEPPLVL QEFVNHGGVL FKVYIVGDAI RVVRRFSLPN VDVGDLSNNA
260 270 280 290 300
GVFRFPRVSC ASANADDADL DPHVAELPPR PLLEILAREL RRRLGLRLFN
310 320 330 340 350
IDMIREHGTR DRFYVIDMNY FPGYGKMPGY EHVFTDFLLS LVQKEYKRRP

SYSSCEG
Length:357
Mass (Da):39,409
Last modified:March 3, 2009 - v1
Checksum:iCCAD00348DD7A54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000128 Genomic DNA Translation: EEC76104.1

Genome annotation databases

EnsemblPlantsiBGIOSGA013495-TA; BGIOSGA013495-PA; BGIOSGA013495
Os03t0726200-01; Os03t0726200-01; Os03g0726200
GrameneiBGIOSGA013495-TA; BGIOSGA013495-PA; BGIOSGA013495
Os03t0726200-01; Os03t0726200-01; Os03g0726200

Similar proteinsi

Entry informationi

Entry nameiITPK3_ORYSI
AccessioniPrimary (citable) accession number: B8AR41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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