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UniProtKB - B8A5L2 (B8A5L2_DANRE)

Entry version 84 (19 Jan 2022)
Sequence version 1 (03 Mar 2009)
Previous versions | rss
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Protein
Submitted name:

F-box protein 10

Gene

fbxo10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-8951664, Neddylation
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
F-box protein 10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fbxo10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-090313-270, fbxo10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		B8A5L2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000061936, Expressed in blastula and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		B8A5L2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000121445

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 48F-boxInterPro annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni291 – 319DisorderedSequence analysisAdd BLAST29
Regioni334 – 378DisorderedSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi291 – 317Polar residuesSequence analysisAdd BLAST27
Compositional biasi357 – 372Acidic residuesSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1777, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063425

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013632_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		B8A5L2

Database for complete collections of gene phylogenies

More...PhylomeDBi		B8A5L2

TreeFam database of animal gene trees

More...TreeFami		TF313602

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.160.20.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039448, Beta_helix
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR007742, NosD_dom
IPR022441, Para_beta_helix_rpt-2
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13229, Beta_helix, 1 hit
PF12937, F-box-like, 1 hit
PF05048, NosD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00256, FBOX, 1 hit
SM00710, PbH1, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51126, SSF51126, 4 hits
SSF81383, SSF81383, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03804, para_beta_helix, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50181, FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

B8A5L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVGDLPVEL WRLILAYLPL PDLGRCCLVC RAWRELILSL DSTRWRQLCL 
        60         70         80         90        100
GCPECRHPNW PRRPHLPPAS WREALRQHAL ASRTWTQNGS DLHSSACLHL 
       110        120        130        140        150
FRRRKDRRVW HVATVAGGGY ESLRGALAVA GPYDKVVLHP GVYEEQVEVA 
       160        170        180        190        200
LKVPVEIVGM GKLGDVSLLV SFDQQCPTAR LCNVVFMPAW FSPVVYKTSS 
       210        220        230        240        250
GHVQLDNCNF EGCQLHIRGP GTCQARFCSF AQGSSAHFLG VTISLMDSCE 
       260        270        280        290        300
FSGGDSASVT VEGPPVSERN WAFKHLVALA KTFTMMTSIG STEMSNQGRK 
       310        320        330        340        350
DSVSTGSNGN SPFEGINTME DWSKPEVDWE TNWAKQKGGD SLLPGQDGTM 
       360        370        380        390        400
IEEDGMETSS ESSEEDDDDD LDGEKSTGLK LSYDQHGLAH LSMTDMPNSA 
       410        420        430        440        450
FPTLLNLSAE LQKDAEARDL AASVQGCLLR RCLLRDGKGG VHLCNHAQAR 
       460        470        480        490        500
LEANVFRGLN YAVRCIQNAK MVMLRNEVCG CKASGVFLRL SAQGLIAENN 
       510        520        530        540        550
IHSNGEAGLD IRKGANPIIL CNRIHSGLRS GIVVLGNGRG SIRSNQIYGN 
       560        570        580        590        600
KEAGVYILFN GNPVVSGNHI FQGLAAGIAV NENGRGLITE NVIRQNQWGG 
       610        620        630        640        650
ADIRRGGDPV LRNNFICYGY SDGVVVGERG RGLVEGNHIY GNRGCGVWVM 
       660        670        680        690        700
SSSLPQLIGN HISHNRMYGL AVFCRKDTES AVNREGYRAL QDRDRGERDN 
       710        720        730        740        750
FNEEGELMAW ESDIDSEDER FSSRRPITVA LVENNCISQN GAVGVFVKSS 
       760        770        780        790        800
EPLNVVSNMV KSNRGAGVCV IQSAQLTRLV GNCVLCNGWT GVSVDRECRV 
       810        820        830        840        850
ELRGNGVYGN TCHGVCFRGD GLIVENDVVD NTTGGIRVMD NADVKLFTLI 
       860        870        880        890        900
YHHEYNLLDP FYYKLGILVR FIPDTVLKIA MITTGWSRAA PPAHAQVLRN 
       910        920        930        940        950
RVQAVRGYGI SVKQLARGVV QENLVYQSRP TTTKTPIRTN AQNLECVVLN 
       960        970        980        990       1000
NSLLTPRSQA LWALENPPAR PHNSNPSSVT PSTIPAHLAL TMTNRITASV 
      1010 
ESGCHNNGSI FCSIL
Length:1,015
Mass (Da):111,086
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7E1D60A77F12E9E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7F5M1E7F5M1_DANRE
F-box protein 10
fbxo10
964Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1R4S8F1R4S8_DANRE
F-box protein 10
fbxo10
271Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QMC2F1QMC2_DANRE
F-box protein 10
fbxo10
533Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q8E6A0A2R8Q8E6_DANRE
F-box protein 10
fbxo10
944Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QA18A0A2R8QA18_DANRE
F-box protein 10
fbxo10
925Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX548248 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000141579; ENSDARP00000121445; ENSDARG00000061936

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548248 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000121445

Proteomic databases

PaxDbiB8A5L2

Genome annotation databases

EnsembliENSDART00000141579; ENSDARP00000121445; ENSDARG00000061936

Organism-specific databases

ZFINiZDB-GENE-090313-270, fbxo10

Phylogenomic databases

eggNOGiKOG1777, Eukaryota
GeneTreeiENSGT00530000063425
HOGENOMiCLU_013632_0_0_1
InParanoidiB8A5L2
PhylomeDBiB8A5L2
TreeFamiTF313602

Enzyme and pathway databases

ReactomeiR-DRE-8951664, Neddylation
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSDARG00000061936, Expressed in blastula and 26 other tissues
ExpressionAtlasiB8A5L2, baseline and differential

Family and domain databases

Gene3Di2.160.20.10, 3 hits
InterProiView protein in InterPro
IPR039448, Beta_helix
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR007742, NosD_dom
IPR022441, Para_beta_helix_rpt-2
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence
PfamiView protein in Pfam
PF13229, Beta_helix, 1 hit
PF12937, F-box-like, 1 hit
PF05048, NosD, 1 hit
SMARTiView protein in SMART
SM00256, FBOX, 1 hit
SM00710, PbH1, 13 hits
SUPFAMiSSF51126, SSF51126, 4 hits
SSF81383, SSF81383, 1 hit
TIGRFAMsiTIGR03804, para_beta_helix, 1 hit
PROSITEiView protein in PROSITE
PS50181, FBOX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB8A5L2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B8A5L2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: January 19, 2022
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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