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Entry version 87 (29 Sep 2021)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Collagen, type XVII, alpha 1a

Gene

col17a1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type XVII, alpha 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:col17a1aImported
Synonyms:si:ch211-281g13.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-090313-107, col17a1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei536 – 560HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B8A4S4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000069415, Expressed in embryo and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000122777

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni167 – 284DisorderedSequence analysisAdd BLAST118
Regioni296 – 315DisorderedSequence analysisAdd BLAST20
Regioni632 – 1124DisorderedSequence analysisAdd BLAST493
Regioni1138 – 1160DisorderedSequence analysisAdd BLAST23
Regioni1215 – 1239DisorderedSequence analysisAdd BLAST25
Regioni1290 – 1339DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi167 – 255Polar residuesSequence analysisAdd BLAST89
Compositional biasi257 – 271Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi896 – 915Pro residuesSequence analysisAdd BLAST20
Compositional biasi928 – 943Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi953 – 984Pro residuesSequence analysisAdd BLAST32
Compositional biasi1098 – 1115Pro residuesSequence analysisAdd BLAST18
Compositional biasi1298 – 1332Pro residuesSequence analysisAdd BLAST35

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168136

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004285_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B8A4S4

Database of Orthologous Groups

More...
OrthoDBi
718661at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332289

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160, Collagen

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391, Collagen, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B8A4S4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKLTTTKIV KVEGGSGGSG KEIQKHTETV TTTRLTSLPP KAHSGQQILT
60 70 80 90 100
SIGNGSGSAG GAVLLEKKFI THSSAEGGAS RSYVISSSSS GSSASSSSGA
110 120 130 140 150
GSVISGFDGI SGEISVTGPI TSSTVKSSTS AVKSSSVVST SITSSSAAGG
160 170 180 190 200
ELSSGYGSIS SSSSEFVSGS SGGSISTSEG SMSKSRSGGG SSAVMSGEGT
210 220 230 240 250
SSSKTVSKFS SSSPSGTRKG LSYSTVPTER KTIMNITTGG YEGSSSGNSS
260 270 280 290 300
PEYIKKDSAA TRGRTQTRES EIRARLQSAS PSARWTELDD VKRLLKGSRS
310 320 330 340 350
GSISPPRSPT STLPIPKKAS IDVRHESQSG FDGTVLDAGF SGYYTNPNNL
360 370 380 390 400
SYTTLQQPSS PTGGMQNNLT LSSSALDTTV YGMQNNLSTS GGAMMANGRC
410 420 430 440 450
TGYVYGVPKN VGSAGLATTI SAIPSSPITA DDVFMKDGKL IAIGKENVAA
460 470 480 490 500
KTETERLIMS KNTGKQFVPS SFNAGADTFS EDSLKREKKM ISSATDPQTT
510 520 530 540 550
TITGSKSSTK NKATYADIRK DDSDGAGCGF WTCCSWWKWL LALLFALLLL
560 570 580 590 600
LGLLCGLIAL GEQLRRLKAR VDAIDGGGTS PRTSGLKTDD IPGVQSGNTI
610 620 630 640 650
NLGYEPAGQD SLILQRAILR ELQSDTIRAS LATSLRGERG EPGPKGDQGP
660 670 680 690 700
PGVKGDSGFP GIPGPPGLIG HPGQEGPRGP KGSAGESGSD GLPGPRGREG
710 720 730 740 750
PAGPRGEPGP PGIGEKGEKG SFGDVGAPGI AGPPGPVGPK GDAGAQGVPG
760 770 780 790 800
LTGAPGPQGF RGDSGDPGPK GDKGPAGPPG VKGDQGERGP RGATGEPGQP
810 820 830 840 850
GPAGPPGEKG LKGSTGAPGP DGVKGLRGDQ GPVGLPGARG PSGPPGDSGI
860 870 880 890 900
PGTPGLQGPP GLPGTPGQPG AKGEAGEPGR VISAGANANT VAVSGPPGPP
910 920 930 940 950
GAPGPAGPPG LSGPIGPAGL PGSPGAKGDK GDKGEDGKPG VTESAGKKSE
960 970 980 990 1000
AGEPGPPGPP GPPGPPGDDG KPGVGEPGPA GPPGEKGEPG SFVPTSETFF
1010 1020 1030 1040 1050
AGPPGPPGPI GPKGSQGDVG PQGFPGQPGL PGEPGIGIPG QPGSPGPRGE
1060 1070 1080 1090 1100
QGLDGPLGPQ GPQGPMGPMG PEGPKGDAGV PGAPGIPGYS YGGGSRSAPG
1110 1120 1130 1140 1150
PPGPPGPPGP PGEPGSQGDG SPNAVQQISD YLRSEPIRQY LAGPPGPPGP
1160 1170 1180 1190 1200
PGPSGSASDD ALASRVIEYL QRDEVRQYLI GPPGPPGPPG VPGGYGFNTQ
1210 1220 1230 1240 1250
EVAGRVMSLI NDAGFRGLPG PPGPPGPQGP PGNSGGLVSY AANENQQHIR
1260 1270 1280 1290 1300
AEPQEYIKSH PRADENLDYT AIAKQVSDYI KAHGLLNGNA GFPGAPGRQG
1310 1320 1330 1340 1350
YPGPPGFPGE PGTPGQPGPP GQAGPPGLPG PPGLDTVHNY SNMTAVLDYI
1360 1370 1380 1390 1400
KENHMKGQKG DLGFPGIPGS PGIDGKQGIV GLPGIKGQKG ERGEATYVNR

RRRRSTVI
Length:1,408
Mass (Da):139,247
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43982D65A1277BE2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX321880 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001139037.1, NM_001145565.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000142957; ENSDARP00000122777; ENSDARG00000069415

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
557257

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:557257

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX321880 Genomic DNA No translation available.
RefSeqiNP_001139037.1, NM_001145565.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000122777

Proteomic databases

PaxDbiB8A4S4

Genome annotation databases

EnsembliENSDART00000142957; ENSDARP00000122777; ENSDARG00000069415
GeneIDi557257
KEGGidre:557257

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
557257
ZFINiZDB-GENE-090313-107, col17a1a

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00940000168136
HOGENOMiCLU_004285_0_0_1
InParanoidiB8A4S4
OrthoDBi718661at2759
TreeFamiTF332289

Gene expression databases

BgeeiENSDARG00000069415, Expressed in embryo and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR008160, Collagen
PfamiView protein in Pfam
PF01391, Collagen, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB8A4S4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B8A4S4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 29, 2021
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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