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Protein

Protein Wnt

Gene

wnt8a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotationSAAS annotation
Biological processWnt signaling pathwayUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-3238698 WNT ligand biogenesis and trafficking
R-DRE-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WntUniRule annotation
Gene namesi
Name:wnt8aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-980526-332 wnt8a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrixSAAS annotation, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500286440821 – 353Protein WntSequence analysisAdd BLAST333

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiB8A4J5

Expressioni

Gene expression databases

BgeeiENSDARG00000078507

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096426

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00690000101857
HOVERGENiHBG001595
OMAiRECLQHG
OrthoDBiEOG091G0B1B

Family and domain databases

InterProiView protein in InterPro
IPR034312 Protein_Wnt-8A/8C
IPR005817 Wnt
IPR013301 Wnt8
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF92 PTHR12027:SF92, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01892 WNT8PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

B8A4J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYFFRWAFL FPIWDKAILG HTWTMNNLLI TGPKAYLTYA NSVRVGAQSG
60 70 80 90 100
IHECKHQFAW DRWNCPDTAL QLSTHKGLRT TRESSFVHAI SAAGVMYTLT
110 120 130 140 150
RNCSLGDLNE CGCDSSRNGR LGGRGWLWGG CSDNVDFGER ISKQFVDALE
160 170 180 190 200
TGQDARAAVN LHNNEAGRLA VKATMKRICR CHGMSESCTM QTCWMQLADF
210 220 230 240 250
REIGNYLKVK HDQAQKLEMD KRRMRAGNSA DNRVTMTDAF GSIARTELIY
260 270 280 290 300
LEDSPDYCAK NLSLGLPGTE GRECVQHGES LSQWERRSCR RLCHECGLRV
310 320 330 340 350
EERRTEVVSS CNCKFHWCCT VKCENCSQVT VKHVCTRRHG SHGHNRRRPR

GPK
Length:353
Mass (Da):40,053
Last modified:March 3, 2009 - v1
Checksum:iCABA0947F0A70AE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248097 Genomic DNA No translation available.
BX927327 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSDART00000147756; ENSDARP00000119476; ENSDARG00000078507

Similar proteinsi

Entry informationi

Entry nameiB8A4J5_DANRE
AccessioniPrimary (citable) accession number: B8A4J5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 20, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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