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Entry version 51 (29 Sep 2021)
Sequence version 1 (03 Mar 2009)
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Protein

General transcription factor II-I repeat domain-containing protein 1

Gene

gtf2ird1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that activates a subset of organizer-specific genes. Binds to the distal element (DE) of the gsc promoter to regulate its expression. In the presence of pou5f1.1/oct-25, forms a repression complex on the promoter of the gsc and mix2 genes to inhibit their transcription.

3 Publications

Caution

There is conflicting evidence as to whether gtf2ird1 acts as a transcriptional activator or repressor when directly bound to the distal element of the gsc promoter. PubMed:11937490 shows that gtf2ird1 acts cooperatively with smads and foxh1/fast1 to activate activin/nodal-mediated gsc transcription. However, PubMed:16055724 report that in the absence of TGF-beta, gtf2ird1 represses gsc transcription. Upon TGF-beta stimulation, smad2 is translocated to the nucleus as a complex with smad4, interacts with TFII-I, and binds to the distal element to dislodge gtf2ird1 and up-regulate gsc gene transcription.Curated2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
General transcription factor II-I repeat domain-containing protein 1By similarity
Alternative name(s):
Binding factor for early enhancer1 Publication
Short name:
BEN1 Publication
Short name:
XBEN1 Publication
GTF2I repeat domain-containing protein 1
Williams-Beuren syndrome critical region 11-like proteinImported
Short name:
XWBSCR111 PublicationBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gtf2ird1
Synonyms:wbscr11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-5857419, gtf2ird1.S

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003907401 – 993General transcription factor II-I repeat domain-containing protein 1Add BLAST993

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B7ZQJ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Uniformly expressed in the embryo in pre- and early gastrula stages. Enriched in the head region of early neurula through tailbud stages.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically at relatively consistent levels throughout development.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via repeats 4-5) with foxh1/fast1 (via Fork-head domain).

Interacts with smad2 and smad3 (via MH1 domain) in a ligand (activin)-dependent manner.

Interacts with pou5f1.1/oct-25 to form a repression complex on the promoters of the gsc and mix2 genes.

2 Publications

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B7ZQJ9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati117 – 211GTF2I-like 1Sequence analysisAdd BLAST95
Repeati332 – 426GTF2I-like 2Sequence analysisAdd BLAST95
Repeati597 – 691GTF2I-like 3Sequence analysisAdd BLAST95
Repeati727 – 821GTF2I-like 4Sequence analysisAdd BLAST95
Repeati824 – 918GTF2I-like 5Sequence analysisAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni461 – 480DisorderedSequence analysisAdd BLAST20
Regioni916 – 961DisorderedSequence analysisAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi929 – 936Nuclear localization signalBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi939 – 961Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFII-I family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
115381at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1460.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004212, GTF2I
IPR036647, GTF2I-like_rpt_sf
IPR016659, TF_II-I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02946, GTF2I, 5 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016441, TF_II-I, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117773, SSF117773, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51139, GTF2I, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7ZQJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALAGKQYEG SLNNSRPNLW PSSIPGGKNE IITSLVTALD SMCTALSKLN
60 70 80 90 100
TEVACIALHE ESAFVVGTEK GRCFLNSRKE LQADFQRFCI GAHKKDQENE
110 120 130 140 150
VKRRNRDGIQ NIQHVPLGPT SDIYLLRKMV EEIFEVLYSE ALGKSNIVPV
160 170 180 190 200
PYVKVMKEPG SVVVLGLPDG ISFRKPAEYD LKSLMLILKH SHNIRFKLRI
210 220 230 240 250
PTEESIREPK SCSELNSPPT SATKVIPETS QCHRLPIQEH PSSASNFPYS
260 270 280 290 300
VSQPNQISLE PKQEVHSNML GTNAVNQMLV QRPSAENNHD LSDCCGQQSP
310 320 330 340 350
VAGSSLRQNV LASKHLLFSI VHDKTDKWDS FLRETEDINI LRECVQILFN
360 370 380 390 400
SRYAGALGLD HMVPVPYRKI ACHPEAVEIN GFPDKIPFKR PCTYGVPKLK
410 420 430 440 450
RILEERHNIH FTIKSMFDQR IFDGTTFTKE TTKSDSSSLG EEACSENQKA
460 470 480 490 500
AALDMLGFPT GSRSEKSSIS DECEPGTSSE TTGVKLIKLE AEDPDIMQIA
510 520 530 540 550
VPGTSSETSG VKIIKLESED PDLIQITVPG TSNETSGVKP KLESEDPDLI
560 570 580 590 600
QIAVPDRLAE CVKNHLAPED PSYVLDTGKV CDDRPCGVLR NENKHLDGIG
610 620 630 640 650
DIIRQLRKHV ENLFNRKYAK AIGASGPVKV PYAKFLMYPE DLFVLGLPEG
660 670 680 690 700
VAFRRPNCFG ITKLRRILEY SDGIQFVVKR PELISEGLED CVVGSPGTLG
710 720 730 740 750
FNDKSNEVIL DETNTRPSFQ ESFDARLSRI DIANTLREQV QVLFNKKYGE
760 770 780 790 800
ALGIKYPVQV PYKRIKNNPG SVIIEGLPPG IPFRKPCTFG SQNLERILAV
810 820 830 840 850
ADKIRFTVTR PFQGLIPRPD DEDANRLGEK VILREQVKEL FNEKYGKALG
860 870 880 890 900
LDQPALIPYK LIRDNPDAVE VRGMPNDIPF RNPNSYDLHR LENILKAQDQ
910 920 930 940 950
IQMVVIKQLE PFPEICSEPP KIKNGNTGPK RKRKRVSEGN SISSASSNCS
960 970 980 990
SSSSSSSNMD PISSAHHVSL VQWPMYMLDY GGLNMQLPGP INY
Length:993
Mass (Da):110,574
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC903FCF89748061E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti513I → L in AAM28813 (PubMed:11937490).Curated1
Sequence conflicti579K → KR in AAM28813 (PubMed:11937490).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF482757 mRNA Translation: AAM28813.1
BC169835 mRNA Translation: AAI69835.1

NCBI Reference Sequences

More...
RefSeqi
NP_001082250.1, NM_001088781.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
398320

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:398320

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482757 mRNA Translation: AAM28813.1
BC169835 mRNA Translation: AAI69835.1
RefSeqiNP_001082250.1, NM_001088781.1

3D structure databases

SMRiB7ZQJ9
ModBaseiSearch...

Proteomic databases

PRIDEiB7ZQJ9

Genome annotation databases

GeneIDi398320
KEGGixla:398320

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
398320
XenbaseiXB-GENE-5857419, gtf2ird1.S

Phylogenomic databases

OrthoDBi115381at2759

Family and domain databases

Gene3Di3.90.1460.10, 5 hits
InterProiView protein in InterPro
IPR004212, GTF2I
IPR036647, GTF2I-like_rpt_sf
IPR016659, TF_II-I
PfamiView protein in Pfam
PF02946, GTF2I, 5 hits
PIRSFiPIRSF016441, TF_II-I, 1 hit
SUPFAMiSSF117773, SSF117773, 5 hits
PROSITEiView protein in PROSITE
PS51139, GTF2I, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGT2D1_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7ZQJ9
Secondary accession number(s): Q8JJ22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: March 3, 2009
Last modified: September 29, 2021
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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