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Entry version 74 (12 Aug 2020)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Garnl1 protein

Gene

Ralgapa1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Garnl1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ralgapa1Imported
Synonyms:Garnl1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1931050, Ralgapa1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B7ZNA3

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B7ZNA3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1842 – 2050Rap-GAPInterPro annotationAdd BLAST209

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni343 – 384DisorderedSequence analysisAdd BLAST42
Regioni474 – 496DisorderedSequence analysisAdd BLAST23
Regioni714 – 748DisorderedSequence analysisAdd BLAST35
Regioni854 – 881DisorderedSequence analysisAdd BLAST28
Regioni895 – 958DisorderedSequence analysisAdd BLAST64
Regioni1033 – 1058DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1772 – 1792Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi348 – 363PolyampholyteSequence analysisAdd BLAST16
Compositional biasi364 – 384PolarSequence analysisAdd BLAST21
Compositional biasi474 – 489PolyampholyteSequence analysisAdd BLAST16
Compositional biasi714 – 746PolarSequence analysisAdd BLAST33
Compositional biasi865 – 879PolarSequence analysisAdd BLAST15
Compositional biasi940 – 958PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
IPR027107, Tuberin/Ral-act_asu

The PANTHER Classification System

More...
PANTHERi
PTHR10063, PTHR10063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02145, Rap_GAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347, SSF111347, 1 hit
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50085, RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7ZNA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH
60 70 80 90 100
FSHIYYVFFE NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH
110 120 130 140 150
QRWQFHSIGL ILKKLLHTGN SLKIRREGVR LFLLWLQALQ DNCSKEQLWM
160 170 180 190 200
FSCLIPGFSA PQSEYGPRTL DNLINPPLSL QETQVTIEEV TPLVPPQSGD
210 220 230 240 250
KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL FSHFKKFYLP
260 270 280 290 300
YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ
310 320 330 340 350
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK
360 370 380 390 400
NDTVDKVDKS AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV
410 420 430 440 450
FSSKRSNVNF VTEIFRQAFL LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ
460 470 480 490 500
EPEDTAITCS DIPCSETVAD HDSAIEDGEK REEENGTSTS EHVRNSSWTK
510 520 530 540 550
NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL EPANEIKNLL
560 570 580 590 600
DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF
610 620 630 640 650
LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS
660 670 680 690 700
LTYWEELATE WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK
710 720 730 740 750
GVGHEFQKVS VDKSFSRGWS RDQPGQAPMR QRSATTTGSP GTEKARSIVR
760 770 780 790 800
QKTVAMRSRS IGECALPSAY IRSAKSAPVL IHTSKPFLPD IVLTPLSDEL
810 820 830 840 850
SDIDDAQILP RSTRVRHFSQ SEDTGNEVFG ALHEEQPLPR SSSTSDILEP
860 870 880 890 900
FTVERAKVNK EDTSPKLPPL NSETGGNSAN VPDLMDEFIA ERLRSGNAST
910 920 930 940 950
MTRRGSSPGS LEIPKDLPDI LNKQNQMRPV DDPGVPSEWT SPASAGSSDL
960 970 980 990 1000
MSSDSHSDSF SAFQCEGRKF DNFGFGTDIG IPSSADVDLG SGHHQSTEEQ
1010 1020 1030 1040 1050
EVASLTTLHL DSETSSLNQQ AFSAEVATVT GSESASPVHS ALGSRSQTPS
1060 1070 1080 1090 1100
PSTLSRAHIE QKDLQLDEKL HHSVLQTPDD LEISEFPSEC CSVMAGGTLT
1110 1120 1130 1140 1150
GWHADVATVM WRRMLGILGD VNAIMDPEIH AQVFDYLCEL WQNLAKIRDN
1160 1170 1180 1190 1200
LGISADNLTS PSPPVLIPPL RILTPWLFKA AMLTDKYKQG KLHAYKLICN
1210 1220 1230 1240 1250
TMKRRQDVSP NRDFLTHFYN IMHCGLLHID QDIVNTIIKH CSPQFFSLGL
1260 1270 1280 1290 1300
PGATMLIMDF IIAAGRVASS AFLNAPRVEA QVLLGSLVCF PNLYCELPAL
1310 1320 1330 1340 1350
HPNIPDIAVS QFTDVKELII KTVLSSARDE PSGPARCVAL CSLGIWICEE
1360 1370 1380 1390 1400
LVHESHHPQI KEALNVICVS LKFTNKTVAH VACNMLHMLV HYVPRLQIHQ
1410 1420 1430 1440 1450
PQSPLKIIQI LIATITHLLP STEASSYEMD KRLVVSLLLC LLDWIMALPL
1460 1470 1480 1490 1500
KTLLQPVHAT GAENDKTEKS VLNCIYKVLH GCVYGAQSFS NPKYFPISLS
1510 1520 1530 1540 1550
DLASVDYDPF MHLESLKEPE PLHSPDSERS SKLQPVTEVK TQMQQGLISI
1560 1570 1580 1590 1600
AARTVITHLV NHLGHYPMSG GPAMLTSQVC ENHDNHYSES TELSPELFES
1610 1620 1630 1640 1650
PNIQFFVLNN TTLVSCIQIR SEESMPGGGL AAGLVSANSN VRIIVRDLSG
1660 1670 1680 1690 1700
KYSWDSAILY GPPIVSGLPE PTSFILSMSD QEKPEEPPTS NECLEDIAVK
1710 1720 1730 1740 1750
DGLSLQLRRF RETVPTWSTI REEEDVLDEL LQYLGTTSPE CLQRTGISLN
1760 1770 1780 1790 1800
VPAPQPLCIS EKQENDVINA ILKQYTEEKE FVEKHFNDLN MKASEQDEPT
1810 1820 1830 1840 1850
PQKPQSAFYY CRLLLSILGM NSWDKRRSFH LLKKNEKLLR ELRNLDSRQC
1860 1870 1880 1890 1900
RETHKIAVFY VAEGQEDKYS ILTNIGGSQA YEDFVAGLGW EVNLTNHCGF
1910 1920 1930 1940 1950
MGGLQKNRST GLTTPYFATS TVEVIFHVST RMPSDSDDSL TKKLRHLGND
1960 1970 1980 1990 2000
EVHIVWSEHT RDYRRGIIPT EFGDVLIVIY PMKNHMFSIQ IMKKPEVPFF
2010 2020 2030 2040 2050
GPLFDGAIVN GKVLPIMVRS TAINASRALK SLIPLYQNFY EERARYLQTI
2060 2070 2080
VQHHLEPTTF EDFAAQVFSP APYHHFPADA DH
Length:2,082
Mass (Da):234,381
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90B5373764C36828
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC145119 mRNA Translation: AAI45120.1
BC150707 mRNA Translation: AAI50708.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
uc011ymb.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145119 mRNA Translation: AAI45120.1
BC150707 mRNA Translation: AAI50708.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiB7ZNA3

Proteomic databases

PeptideAtlasiB7ZNA3

Genome annotation databases

UCSCiuc011ymb.2, mouse

Organism-specific databases

MGIiMGI:1931050, Ralgapa1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ralgapa1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
IPR027107, Tuberin/Ral-act_asu
PANTHERiPTHR10063, PTHR10063, 1 hit
PfamiView protein in Pfam
PF02145, Rap_GAP, 1 hit
SUPFAMiSSF111347, SSF111347, 1 hit
SSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50085, RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7ZNA3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7ZNA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: August 12, 2020
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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