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Entry version 37 (31 Jul 2019)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

TACC2 protein

Gene

TACC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TACC2 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TACC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B7ZMJ9

PRoteomics IDEntifications database

More...
PRIDEi
B7ZMJ9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2669 – 2869TACC_CInterPro annotationAdd BLAST201

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 302DisorderedSequence analysisAdd BLAST302
Regioni314 – 333DisorderedSequence analysisAdd BLAST20
Regioni392 – 453DisorderedSequence analysisAdd BLAST62
Regioni465 – 785DisorderedSequence analysisAdd BLAST321
Regioni825 – 965DisorderedSequence analysisAdd BLAST141
Regioni985 – 1155DisorderedSequence analysisAdd BLAST171
Regioni1241 – 1275DisorderedSequence analysisAdd BLAST35
Regioni1296 – 1400DisorderedSequence analysisAdd BLAST105
Regioni1424 – 1458DisorderedSequence analysisAdd BLAST35
Regioni1498 – 1661DisorderedSequence analysisAdd BLAST164
Regioni1675 – 1705DisorderedSequence analysisAdd BLAST31
Regioni1741 – 1858DisorderedSequence analysisAdd BLAST118
Regioni1948 – 2039DisorderedSequence analysisAdd BLAST92
Regioni2056 – 2464DisorderedSequence analysisAdd BLAST409
Regioni2559 – 2625DisorderedSequence analysisAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2678 – 2726Sequence analysisAdd BLAST49
Coiled coili2738 – 2779Sequence analysisAdd BLAST42
Coiled coili2787 – 2832Sequence analysisAdd BLAST46
Coiled coili2837 – 2871Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 36PolarSequence analysisAdd BLAST36
Compositional biasi184 – 198PolarSequence analysisAdd BLAST15
Compositional biasi242 – 265PolarSequence analysisAdd BLAST24
Compositional biasi510 – 543Pro-richSequence analysisAdd BLAST34
Compositional biasi602 – 632PolyampholyteSequence analysisAdd BLAST31
Compositional biasi826 – 843PolarSequence analysisAdd BLAST18
Compositional biasi886 – 935PolarSequence analysisAdd BLAST50
Compositional biasi985 – 1000PolarSequence analysisAdd BLAST16
Compositional biasi1382 – 1400PolarSequence analysisAdd BLAST19
Compositional biasi1547 – 1561PolarSequence analysisAdd BLAST15
Compositional biasi1798 – 1822PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1837 – 1858PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1965 – 1990Pro-richSequence analysisAdd BLAST26
Compositional biasi2075 – 2103PolarSequence analysisAdd BLAST29
Compositional biasi2116 – 2132PolarSequence analysisAdd BLAST17
Compositional biasi2170 – 2184PolarSequence analysisAdd BLAST15
Compositional biasi2350 – 2401PolarSequence analysisAdd BLAST52
Compositional biasi2419 – 2443PolyampholyteSequence analysisAdd BLAST25
Compositional biasi2447 – 2461Pro-richSequence analysisAdd BLAST15
Compositional biasi2559 – 2592PolarSequence analysisAdd BLAST34

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154495

Database of Orthologous Groups

More...
OrthoDBi
669540at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039915 TACC
IPR007707 TACC_C

The PANTHER Classification System

More...
PANTHERi
PTHR13924 PTHR13924, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05010 TACC_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7ZMJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNENSTSDN QRTLSAQTPR SAQPPGNSQN IKRKQQDTPG SPDHRDASSI
60 70 80 90 100
GSVGLGGFCT ASESSASLDP CLVSPEVTEP RKDPQGARGP EGSLLPSPPP
110 120 130 140 150
SQEREHPSSS MPFAECPPEG CLASPAAAPE DGPQTQSPRR EPAPNAPGDI
160 170 180 190 200
AAAFPAERDS STPYQEIAAI PSAGRERQPK EEGQKSSFSF SSGIDQSPGM
210 220 230 240 250
SPVPLREPMK APLCGEGDQP GGFESQEKEA AGGFPPAESR QGVASVQVTP
260 270 280 290 300
EAPAAAQQGT ESSAVLEKSP LKPMAPIPQD PAPRASDRER GQGEAPPQYL
310 320 330 340 350
TDDLEFLRAC HLPRSNSGAA PEAEVNAASQ ESCQQPVGAY LPHAELPWGL
360 370 380 390 400
PSPALVPEAG GSGKEALDTI DVQGHPQTGM RGTKPNQVVC VAAGGQPEGG
410 420 430 440 450
LPVSPEPSLL TPTEEAHPAS SLASFPAAQI PIAVEEPGSS SRESVSKAGM
460 470 480 490 500
PVSADAAKEV VDAGLVGLER QVSDLGSKGE HPEGDPGEVP APSPQERGEH
510 520 530 540 550
LNTEQSHEVQ PGVPPPPLPK EQSHEVQPGA PPPPLPKAPS ESARGPPGPT
560 570 580 590 600
DGAKVHEDST SPAVAKEGSR SPGDSPGGKE EAPEPPDGGD PGNLQGEDSQ
610 620 630 640 650
AFSSKRDPEV GKDELSKPSS DAESRDHPSS HSAQPPRKGG AGHTDGPHSQ
660 670 680 690 700
TAEADASGLP HKLGEEDPVL PPVPDGAGEP TVPEGAIWEG SGLQPKCPDT
710 720 730 740 750
LQSREGLGRM ESFLTLESEK SDFPPTPVAE VAPKAQEGES TLEIRKMGSC
760 770 780 790 800
DGEGLLTSPD QPRGPACDAS RQEFHAGVPH PPQGENLAAD LGLTALILDQ
810 820 830 840 850
DQQGIPSCPG EGWIRGAASE WPLLSSEKHF QPSQAQPETS IFDVLKEQAQ
860 870 880 890 900
PPENGKETSP SHPGFKDQGA DSSQIHVPVE PQEDNNLPTH GGQEQALGSE
910 920 930 940 950
LQSQLPKGTL SDTPTSSPTD MVWESSLTEE SELSAPTRQK LPALGEKRPE
960 970 980 990 1000
GACGDGQSSR VSPPAADVLK DFSLAGNFSR KETCCTGQGP NKSQQALADA
1010 1020 1030 1040 1050
LEEGSQHEEA CQRHPGASEA ADGCSPLWGL SKREMASGNT GEAPPCQPDS
1060 1070 1080 1090 1100
VALLDAVPCL PALAPTSPGV TPTQDAPETE ACDETQEGRQ QPVPAPQQKM
1110 1120 1130 1140 1150
ECRATSDAES PKLLASFPSA GEQGGEAGAA ETGGSAGAGD PGKQQAPEKP
1160 1170 1180 1190 1200
GEATLSCGLL QTEHCLTSGE EASTSALRES CQAEHPMASC QDALLPAREL
1210 1220 1230 1240 1250
GGIPRSTMDF STHQAVPDPK ELLLSGPPEV AAPDTPYLHV DSAAQRGAED
1260 1270 1280 1290 1300
SGVKAVSSAD PRAPGESPCP VGEPPLALEN AASLKLFAGS LAPLLQPGAA
1310 1320 1330 1340 1350
GGEIPAVQAS SGSPKARTTE GPVDSMPCLD RMPLLAKGKQ ATGEEKAATA
1360 1370 1380 1390 1400
PGAGAKASGE GMAGDAAGET EGSMERMGEP SQDPKQGTSG GVDTSSEQIA
1410 1420 1430 1440 1450
TLTGFPDFRE HIAKIFEKPV LGALTTPGEK AGAGRSAVGK DLTRPLGPEK
1460 1470 1480 1490 1500
LLDGPPGVDV TLLPAPPARL QVEKKQQLAG EAEISHLALQ DPASDKLLGP
1510 1520 1530 1540 1550
AGLTWERNLP GAGVGKEMAG VPPTLREDER PEGPGAAWPG LEGQAYSQLE
1560 1570 1580 1590 1600
RSRQELASGL PSPAATQELP VERAAAFQVA PHSHGEEAVA QDRIPSGKQH
1610 1620 1630 1640 1650
QETSACDSPH GEDGPGDFAH TGVPGHVPRS TCAPSPQREV LTVPEANSEP
1660 1670 1680 1690 1700
WTLDTLGGER RPGVTAGILE MRNALGNQST PAPPTGEVAD TPLEPGKVAG
1710 1720 1730 1740 1750
AAGEAEGDIT LSTAETQACA SGDLPEAGTT RTFSVVAGDL VLPGSCQDPA
1760 1770 1780 1790 1800
CSDKAPGMEG TAALHGDSPA RPQQAKEQPG PERPIPAGDG KVCVSSPPEP
1810 1820 1830 1840 1850
DETHDPKLQH LAPEELHTDR ESPRPGPSML PSVPKKDAPR VMDKVTSDET
1860 1870 1880 1890 1900
RGAEGTERSA KDIGLWKAMM PSLDTDTLDV LERRVVLIQH EFLHKKEANG
1910 1920 1930 1940 1950
HSRFMYSSPV ADDIIQPAAP ADLESPTLAA SSYHGDVVGQ VSTDLIAQRS
1960 1970 1980 1990 2000
SDSEEAFETP ESTTPVKAPP APPPPPPEVI PEPEVSTQPP PEEPGCGSET
2010 2020 2030 2040 2050
VPVPDGPRSD SVEGSPFRPP SHSFSAVFDE DKPIASSGTY NLDFDNIELV
2060 2070 2080 2090 2100
DTFQTLEPRA SDAKNQEGKV NTRRKSTDSV PISKSTLSRS LSLQASDFDG
2110 2120 2130 2140 2150
ASSSGNPEAV ALAPDAYSTG SSSASSTLKR TKKPRPPSLK KKQTTKKPTE
2160 2170 2180 2190 2200
TPPVKETQQE PDEESLVPSG ENLASETKTE SAKTEGPSPA LLEETPLEPA
2210 2220 2230 2240 2250
VGPKAACPLD SESAEGVVPP ASGGGRVQNS PPVGRKTLPL TTAPEAGEVT
2260 2270 2280 2290 2300
PSDSGGQEDS PAKGLSVRLE FDYSEDKSSW DNQQENPPPT KKIGKKPVAK
2310 2320 2330 2340 2350
MPLRRPKMKK TPEKLDNTPA SPPRSPAEPN DIPIAKGTYT FDIDKWDDPN
2360 2370 2380 2390 2400
FNPFSSTSKM QESPKLPQQS YNFDPDTCDE SVDPFKTSSK TPSSPSKSPA
2410 2420 2430 2440 2450
SFEIPASAME ANGVDGDGLN KPAKKKKTPL KTDTFRVKKS PKRSPLSDPP
2460 2470 2480 2490 2500
SQDPTPAATP ETPPVISAVV HATDEEKLAV TNQKWTCMTV DLEADKQDYP
2510 2520 2530 2540 2550
QPSDLSTFVN ETKFSSPTEE LDYRNSYEIE YMEKIGSSLP QDDDAPKKQA
2560 2570 2580 2590 2600
LYLMFDTSQE SPVKSSPVRM SESPTPCSGS SFEETEALVN TAAKNQHPVP
2610 2620 2630 2640 2650
RGLAPNQESH LQVPEKSSQK ELEAMGLGTP SEAIEIREAA HPTDVSISKT
2660 2670 2680 2690 2700
ALYSRIGTAE VEKPAGLLFQ QPDLDSALQI ARAEIITKER EVSEWKDKYE
2710 2720 2730 2740 2750
ESRREVMEMR KIVAEYEKTI AQMIEDEQRE KSVSHQTVQQ LVLEKEQALA
2760 2770 2780 2790 2800
DLNSVEKSLA DLFRRYEKMK EVLEGFRKNE EVLKRCAQEY LSRVKKEEQR
2810 2820 2830 2840 2850
YQALKVHAEE KLDRANAEIA QVRGKAQQEQ AAHQASLRKE QLRVDALERT
2860 2870
LEQKNKEIEE LTKICDELIA KMGKS
Length:2,875
Mass (Da):302,587
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F9CF1EC62C13598
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC144599 mRNA Translation: AAI44600.1

NCBI Reference Sequences

More...
RefSeqi
NP_001278806.1, NM_001291877.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10579

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144599 mRNA Translation: AAI44600.1
RefSeqiNP_001278806.1, NM_001291877.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB7ZMJ9
PRIDEiB7ZMJ9

Genome annotation databases

GeneIDi10579

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10579

Phylogenomic databases

HOGENOMiHOG000154495
OrthoDBi669540at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TACC2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10579

Family and domain databases

InterProiView protein in InterPro
IPR039915 TACC
IPR007707 TACC_C
PANTHERiPTHR13924 PTHR13924, 4 hits
PfamiView protein in Pfam
PF05010 TACC_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7ZMJ9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7ZMJ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 31, 2019
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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