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UniProtKB - B7ZMI3 (B7ZMI3_HUMAN)
Protein
Inositol 1,4,5-trisphosphate receptor
Gene
ITPR1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
UniRule annotationCaution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- inositol 1,4,5 trisphosphate binding Source: UniProtKB-UniRule
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: UniProtKB-UniRule
GO - Biological processi
- regulation of multicellular organismal process Source: UniProt
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Ligand-gated ion channelUniRule annotation, ReceptorUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol 1,4,5-trisphosphate receptorUniRule annotation |
Gene namesi | Name:ITPR1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6180, ITPR1 |
VEuPathDBi | HostDB:ENSG00000150995 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 367 – 392 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 412 – 434 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 542 – 565 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
Endoplasmic reticulumUniRule annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000150995, Expressed in cauda epididymis and 239 other tissues |
Interactioni
Subunit structurei
Homotetramer.
UniRule annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 166 | MIRInterPro annotationAdd BLAST | 55 | |
Domaini | 231 – 287 | MIRInterPro annotationAdd BLAST | 57 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 692 – 721 | DisorderedSequence analysisAdd BLAST | 30 |
Domaini
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.UniRule annotation
Sequence similaritiesi
Belongs to the InsP3 receptor family.UniRule annotation
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155071 |
HOGENOMi | CLU_383523_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF82109, SSF82109, 1 hit |
PROSITEi | View protein in PROSITE PS50919, MIR, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
B7ZMI3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP
60 70 80 90 100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK
110 120 130 140 150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT
160 170 180 190 200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL
210 220 230 240 250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
310 320 330 340 350
SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVCNKIIFL MSFVGNCGTF
360 370 380 390 400
TRGYRAMVLD VEFLYHLLYL VICAMGLFVH EFFYSLLLFD LVYREETLLN
410 420 430 440 450
VIKSVTRNGR SIILTAVLAL ILVYLFSIVG YLFFKDDFIL EVDRLPNETA
460 470 480 490 500
VPETGESLAS EFLFSDVCRV ESGENCSSPA PREELVPAEE TEQDKEHTCE
510 520 530 540 550
TLLMCIVTVL SHGLRSGGGV GDVLRKPSKE EPLFAARVIY DLLFFFMVII
560 570 580 590 600
IVLNLIFGVI IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVTFE
610 620 630 640 650
EHIKEEHNMW HYLCFIVLVK VKDSTEYTGP ESYVAEMIKE RNLDWFPRMR
660 670 680 690 700
AMSLVSSDSE GEQNELRNLQ EKLESTMKLV TNLSGQLSEL KDQMTEQRKQ
710 720
KQRIGLLGHP PHMNVNPQQP A
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ14643 | ITPR1_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 INSP3R1 | 2,758 | Annotation score: | ||
A0A3B3ITU8 | A0A3B3ITU8_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,744 | Annotation score: | ||
A0A3F2YNW8 | A0A3F2YNW8_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,750 | Annotation score: | ||
A0A3B3IU04 | A0A3B3IU04_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,749 | Annotation score: | ||
A0A3B3ITQ1 | A0A3B3ITQ1_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,012 | Annotation score: | ||
A0A3B3IRT5 | A0A3B3IRT5_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 296 | Annotation score: | ||
A0A3B3ITM6 | A0A3B3ITM6_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 714 | Annotation score: | ||
A0A8C8KBY2 | A0A8C8KBY2_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 1,668 | Annotation score: | ||
A0A3B3IU05 | A0A3B3IU05_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 1,818 | Annotation score: | ||
A0A3B3IU13 | A0A3B3IU13_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 1,739 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC024168 Genomic DNA No translation available. AC069248 Genomic DNA No translation available. AC090944 Genomic DNA No translation available. KF457537 Genomic DNA No translation available. KF457539 Genomic DNA No translation available. KF457546 Genomic DNA No translation available. KF495812 Genomic DNA No translation available. BC144563 mRNA Translation: AAI44564.1 |
Genome annotation databases
Ensembli | ENST00000544951.6; ENSP00000440564.1; ENSG00000150995.21 |
UCSCi | uc011asu.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC024168 Genomic DNA No translation available. AC069248 Genomic DNA No translation available. AC090944 Genomic DNA No translation available. KF457537 Genomic DNA No translation available. KF457539 Genomic DNA No translation available. KF457546 Genomic DNA No translation available. KF495812 Genomic DNA No translation available. BC144563 mRNA Translation: AAI44564.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 7262 |
Protocols and materials databases
Antibodypediai | 5503, 413 antibodies from 41 providers |
Genome annotation databases
Ensembli | ENST00000544951.6; ENSP00000440564.1; ENSG00000150995.21 |
UCSCi | uc011asu.2, human |
Organism-specific databases
HGNCi | HGNC:6180, ITPR1 |
OpenTargetsi | ENSG00000150995 |
VEuPathDBi | HostDB:ENSG00000150995 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155071 |
HOGENOMi | CLU_383523_0_0_1 |
Miscellaneous databases
ChiTaRSi | ITPR1, human |
Gene expression databases
Bgeei | ENSG00000150995, Expressed in cauda epididymis and 239 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF82109, SSF82109, 1 hit |
PROSITEi | View protein in PROSITE PS50919, MIR, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | B7ZMI3_HUMAN | |
Accessioni | B7ZMI3Primary (citable) accession number: B7ZMI3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | May 25, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |