Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

PIK3C2B protein

Gene

PIK3C2B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
PIK3C2B proteinImported
Gene namesi
Name:PIK3C2BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

PeptideAtlasiB7ZM86
PRIDEiB7ZM86

Structurei

3D structure databases

ProteinModelPortaliB7ZM86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini375 – 463PI3K-RBDInterPro annotationAdd BLAST89
Domaini635 – 786C2 PI3K-typeInterPro annotationAdd BLAST152
Domaini776 – 953PIK helicalInterPro annotationAdd BLAST178
Domaini1050 – 1314PI3K/PI4KInterPro annotationAdd BLAST265
Domaini1337 – 1453PXInterPro annotationAdd BLAST117
Domaini1489 – 1580C2InterPro annotationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili27 – 47Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0905 Eukaryota
COG5032 LUCA
HOVERGENiHBG082099

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR001683 Phox
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR036871 PX_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 2 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00142 PI3K_C2, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

B7ZM86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTQGNGEH WKSLESVGIS RKELAMAEAL QMEYDALSRL RHDKEENRAK
60 70 80 90 100
QNADPSLISW DEPGVDFYSK PAGRRTDLKL LRGLSGSDPT LNYNSLSPQE
110 120 130 140 150
GPPNHSTSQG PQPGSDPWPK GSLSGDYLYI FDGSDGGVSS SPGPGDIEGS
160 170 180 190 200
CKKLSPPPLP PRASIWDTPP LPPRKGSPSS SKISQPSDIN TFSLVEQLPG
210 220 230 240 250
KLLEHRILEE EEVLGGGGQG RLLGSVDYDG INDAITRLNL KSTYDAEMLR
260 270 280 290 300
DATRGWKEGR GPLDFSKDTS GKPVARSKTM PPQVPPRTYA SRYGNRKNAT
310 320 330 340 350
PGKNRRISAA PVGSRPHTVA NGHELFEVSE ERDEEVAAFC HMLDILRSGS
360 370 380 390 400
DIQDYFLTGY VWSAVTPSPE HLGDEVNLKV TVLCDRLQEA LTFTCNCSST
410 420 430 440 450
VDLLIYQTLC YTHDDLRNVD VGDFVLKPCG LEEFLQNKHA LGSHEYIQYC
460 470 480 490 500
RKFDIDIRLQ LMEQKVVRSD LARTVNDDQS PSTLNYLVHL QERPVKQTIS
510 520 530 540 550
RQALSLLFDT YHNEVDAFLL ADGDFPLKAD RVVQSVKAIC NALAAVETPE
560 570 580 590 600
ITSALNQLPP CPSRMQPKIQ KDPSVLAVRE NREKVVEALT AAILDLVELY
610 620 630 640 650
CNTFNADFQT AVPGSRKHDL VQEACHFARS LAFTVYATHR IPIIWATSYE
660 670 680 690 700
DFYLSCSLSH GGKELCSPLQ TRRAHFSKYL FHLIVWDQQI CFPVQVNRLP
710 720 730 740 750
RETLLCATLY ALPIPPPGSS SEANKQRRVP EALGWVTTPL FNFRQVLTCG
760 770 780 790 800
RKLLGLWPAT QENPSARWSA PNFHQPDSVI LQIDFPTSAF DIKFTSPPGD
810 820 830 840 850
KFSPRYEFGS LREEDQRKLK DIMQKESLYW LTDADKKRLW EKRYYCHSEW
860 870 880 890 900
THMNHQDALG LLHATFPDQE VRRMAVQWIG SLSDAELLDY LPQLVQALKY
910 920 930 940 950
ECYLDSPLVR FLLKRAVSDL RVTHYFFWLL KDGLKDSQFS IRYQYLLAAL
960 970 980 990 1000
LCCCGKGLRE EFNRQCWLVN ALAKLAQQVR EAAPSARQGI LRTGLEEVKQ
1010 1020 1030 1040 1050
FFALNGSCRL PLSPSLLVKG IVPRDCSYFN SNAVPLKLSF QNVDPLGENI
1060 1070 1080 1090 1100
RVIFKCGDDL RQDMLTLQMI RIMSKIWVQE GLDMRMVIFR CFSTGRGRGM
1110 1120 1130 1140 1150
VEMIPNAETL RKIQVEHGVT GSFKDRPLAD WLQKHNPGED EYEKAVENFI
1160 1170 1180 1190 1200
YSCAGCCVAT YVLGICDRHN DNIMLKTTGH MFHIDFGRFL GHAQMFGNIK
1210 1220 1230 1240 1250
RDRAPFVFTS DMAYVINGGD KPSSRFHDFV DLCCQAYNLI RKHTHLLLNL
1260 1270 1280 1290 1300
LGLMLSCGIP ELSDLEDLKY VYDALRPQDT EANATTYFTR LIESSLGSVA
1310 1320 1330 1340 1350
TKLNFFIHNL AQMKFTGSDD RLTLSFASRT HTLKSSGRIS DVFLCRHEKI
1360 1370 1380 1390 1400
FHPNKGYIYV VKVMRENTHE ATYIQRTFEE FQELHNKLRL LFPSSHLPSF
1410 1420 1430 1440 1450
PSRFVIGRSR GEAVAERRRE ELNGYIWHLI HAPPEVAECD LVYTFFHPLP
1460 1470 1480 1490 1500
RDEKAMGTSP APKSSDGTWA RPVGKVGGEV KLSISYKNNK LFIMVMHIRG
1510 1520 1530 1540 1550
LQLLQDGNDP DPYVKIYLLP DPQKTTKRKT KVARKTCNPT YNEMLVYDGI
1560 1570 1580 1590 1600
PKGDLQQREL QLSVLSEQGF WENVLLGEVN IRLRELDLAQ EKTGWFALGS

RSHGTL
Length:1,606
Mass (Da):181,652
Last modified:March 3, 2009 - v1
Checksum:i6F683B1B88FCB69C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144342 mRNA Translation: AAI44343.1
UniGeneiHs.497487

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144342 mRNA Translation: AAI44343.1
UniGeneiHs.497487

3D structure databases

ProteinModelPortaliB7ZM86
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB7ZM86
PRIDEiB7ZM86

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0905 Eukaryota
COG5032 LUCA
HOVERGENiHBG082099

Miscellaneous databases

ChiTaRSiPIK3C2B human

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR001683 Phox
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR036871 PX_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 2 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00142 PI3K_C2, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit
PS50195 PX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB7ZM86_HUMAN
AccessioniPrimary (citable) accession number: B7ZM86
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again