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Entry version 79 (02 Dec 2020)
Sequence version 1 (03 Mar 2009)
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Protein

Phosphatidylinositol-4-phosphate 3-kinase

Gene

PIK3C2G

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationARBA annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol-4-phosphate 3-kinaseARBA annotation (EC:2.7.1.154ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIK3C2GImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B7ZLY6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini284 – 370PI3K-RBDInterPro annotationAdd BLAST87
Domaini520 – 668C2 PI3K-typeInterPro annotationAdd BLAST149
Domaini683 – 859PIK helicalInterPro annotationAdd BLAST177
Domaini956 – 1220PI3K/PI4KInterPro annotationAdd BLAST265
Domaini1239 – 1351PXInterPro annotationAdd BLAST113

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
204282at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05177, PI3Kc_C2_gamma, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR037707, PI3K-C2-gamma_dom
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR002420, PI3K_C2_dom
IPR000341, PI3K_Ras-bd_dom
IPR015433, PI_Kinase
IPR001683, PX_dom
IPR036871, PX_dom_sf
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR10048, PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF00794, PI3K_rbd, 1 hit
PF00613, PI3Ka, 1 hit
PF00787, PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00142, PI3K_C2, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit
SM00312, PX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF54236, SSF54236, 1 hit
SSF56112, SSF56112, 1 hit
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51547, PI3K_C2, 1 hit
PS51546, PI3K_RBD, 1 hit
PS51545, PIK_HELICAL, 1 hit
PS50195, PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7ZLY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYSWQTDPN PNESHEKQYE HQEFLFVNQP HSSSQVSLGF DQIVDEISGK
60 70 80 90 100
IPHYESEIDE NTFFVPTAPK WDSTGHSLNE AHQISLNEFT SKSRELSWHQ
110 120 130 140 150
VSKAPAIGFS PSVLPKPQNT NKECSWGSIG KHHGADDSRF SILALSFTSL
160 170 180 190 200
DKINLEKELE NENHNYHIGF ESSIPPTNSS FSSDFMPKEE NKRSGHVNIV
210 220 230 240 250
EPSLMLLKGS LQPGMWESTW QKNIESIGCS IQLVEVPQSS NTSLASFCNK
260 270 280 290 300
VKKIRERYHA ADVNFNSGKI WSTTTAFPYQ LFSKTKFNIH IFIDNSTQPL
310 320 330 340 350
HFMPCANYLV KDLIAEILHF CTNDQLLPKD HILSVCGSEE FLQNDHCLGS
360 370 380 390 400
HKMFQKDKSV IQLHLQKSRE APGKLSRKHE EDHSQFYLNQ LLEFMHIWKV
410 420 430 440 450
SRQCLLTLIR KYDFHLKYLL KTQENVYNII EEVKKICSVL GCVETKQITD
460 470 480 490 500
AVNELSLILQ RKGENFYQSS ETSAKGLIEK VTTELSTSIY QLINVYCNSF
510 520 530 540 550
YADFQPVNVP RCTSYLNPGL PSHLSFTVYA AHNIPETWVH SYKAFSFTCW
560 570 580 590 600
LTYAGKKLCQ VRNYRNIPDK KLFFFLVNWN ETINFPLEIK SLPRESMLTV
610 620 630 640 650
KLFGIACATN NANLLAWTCL PLFPKEKSIL GSMLFSMTLQ SEPPVEMITP
660 670 680 690 700
GVWDVSQPSP VTLQIDFPAT GWEYMKPDSE ENRSNLEEPL KECIKHIARL
710 720 730 740 750
SQKQTPLLLS EEKKRYLWFY RFYCNNENCS LPLVLGSAPG WDERTVSEMH
760 770 780 790 800
TILRRWTFSQ PLEALGLLTS SFPDQEIRKV AVQQLDNLLN DELLEYLPQL
810 820 830 840 850
VQAVKFEWNL ESPLVQLLLH RSLQSIQVAH RLYWLLKNAE NEAYFKSWYQ
860 870 880 890 900
KLLAALQFCA GKALNDEFSK EQKLIKILGD IGERVKSASD HQRQEVLKKE
910 920 930 940 950
IGRLEEFFQD VNTCHLPLNP ALCIKGIDHD ACSYFTSNAL PLKITFINAN
960 970 980 990 1000
LMGKNISIIF KAGDDLRQDM LVLQLIQVMD NIWLQEGLDM QMIIYRCLST
1010 1020 1030 1040 1050
GKDQGLVQMV PDAVTLAKIH RHSGLIGPLK ENTIKKWFSQ HNHLKADYEK
1060 1070 1080 1090 1100
ALRNFFYSCA GWCVVTFILG VCDRHNDNIM LTKSGHMFHI DFGKFLGHAQ
1110 1120 1130 1140 1150
TFGGIKRDRA PFIFTSEMEY FITEGGKNPQ HFQDFVELCC RAYNIIRKHS
1160 1170 1180 1190 1200
QLLLNLLEMM LYAGLPELSG IQDLKYVYNN LRPQDTDLEA TSHFTKKIKE
1210 1220 1230 1240 1250
SLECFPVKLN NLIHTLAQMS AISPAKSTSQ TFPQESCLLS TTRSIERATI
1260 1270 1280 1290 1300
LGFSKKSSNL YLIQVTHSNN ETSLTEKSFE QFSKLHSQLQ KQFASLTLPE
1310 1320 1330 1340 1350
FPHWWHLPFT NSDHRRFRDL NHYMEQILNV SHEVTNSDCV LSFFLSEAVQ
1360 1370 1380 1390 1400
QTVEESSPVY LGEKFPDKKP KVQLVISYED VKLTILVKHM KNIHLPDGSA
1410 1420 1430 1440 1450
PSAHVEFYLL PYPSEVRRRK TKSVPKCTDP TYNEIVVYDE VTELQGHVLM
1460 1470 1480
LIVKSKTVFV GAINIRLCSV PLDKEKWYPL GNSII
Length:1,485
Mass (Da):170,617
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3374B4AA9895148
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC144134 mRNA Translation: AAI44135.1

NCBI Reference Sequences

More...
RefSeqi
NP_001275701.1, NM_001288772.1
NP_001275703.1, NM_001288774.1
NP_004561.3, NM_004570.5

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5288

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5288

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144134 mRNA Translation: AAI44135.1
RefSeqiNP_001275701.1, NM_001288772.1
NP_001275703.1, NM_001288774.1
NP_004561.3, NM_004570.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB7ZLY6

Genome annotation databases

GeneIDi5288
KEGGihsa:5288

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5288

Phylogenomic databases

OrthoDBi204282at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5288, 3 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PIK3C2G, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5288

Family and domain databases

CDDicd05177, PI3Kc_C2_gamma, 1 hit
Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR037707, PI3K-C2-gamma_dom
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR002420, PI3K_C2_dom
IPR000341, PI3K_Ras-bd_dom
IPR015433, PI_Kinase
IPR001683, PX_dom
IPR036871, PX_dom_sf
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR10048, PTHR10048, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF00794, PI3K_rbd, 1 hit
PF00613, PI3Ka, 1 hit
PF00787, PX, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00142, PI3K_C2, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit
SM00312, PX, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF54236, SSF54236, 1 hit
SSF56112, SSF56112, 1 hit
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51547, PI3K_C2, 1 hit
PS51546, PI3K_RBD, 1 hit
PS51545, PIK_HELICAL, 1 hit
PS50195, PX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7ZLY6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7ZLY6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 2, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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