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Entry version 71 (12 Aug 2020)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

LTBP1 protein

Gene

LTBP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LTBP1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LTBP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500286695121 – 1353Sequence analysisAdd BLAST1333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi77 ↔ 87PROSITE-ProRule annotation
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B7ZLY3

PRoteomics IDEntifications database

More...
PRIDEi
B7ZLY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B7ZLY3, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
B7ZLY3, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 105EGF-likeInterPro annotationAdd BLAST33
Domaini231 – 276TBInterPro annotationAdd BLAST46
Domaini300 – 337EGF-likeInterPro annotationAdd BLAST38
Domaini351 – 403TBInterPro annotationAdd BLAST53
Domaini547 – 584EGF-likeInterPro annotationAdd BLAST38
Domaini589 – 630EGF-likeInterPro annotationAdd BLAST42
Domaini712 – 752EGF-likeInterPro annotationAdd BLAST41
Domaini753 – 793EGF-likeInterPro annotationAdd BLAST41
Domaini794 – 834EGF-likeInterPro annotationAdd BLAST41
Domaini835 – 875EGF-likeInterPro annotationAdd BLAST41
Domaini876 – 917EGF-likeInterPro annotationAdd BLAST42
Domaini979 – 1033TBInterPro annotationAdd BLAST55
Domaini1099 – 1135EGF-likeInterPro annotationAdd BLAST37
Domaini1156 – 1209TBInterPro annotationAdd BLAST54
Domaini1253 – 1289EGF-likeInterPro annotationAdd BLAST37
Domaini1294 – 1338EGF-likeInterPro annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni424 – 483DisorderedSequence analysisAdd BLAST60

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR017878, TB_dom
IPR036773, TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 12 hits
PF00683, TB, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 16 hits
SM00179, EGF_CA, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 3 hits
SSF57581, SSF57581, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 10 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 12 hits
PS01187, EGF_CA, 6 hits
PS51364, TB, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7ZLY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTKLMCLLF FFSLPPLLVS NHTGRIKVVF TPSICKVTCT KGSCQNSCEK
60 70 80 90 100
GNTTTLISEN GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT
110 120 130 140 150
GKLCQIPVHG ASVPKLYQHS QQPGKALGTH VIHSTHTLPL TVTSQQGVKV
160 170 180 190 200
KFPPNIVNIH VKHPPEASVQ IHQVSRIDGP TGQKTKEAQP GQSQVSYQGL
210 220 230 240 250
PVQKTQTIHS TYSHQQVIPH VYPVAAKTQL GRCFQETIGS QCGKALPGLS
260 270 280 290 300
KQEDCCGTVG TSWGFNKCQK CPKKPSYHGY NQMMECLPGY KRVNNTFCQD
310 320 330 340 350
INECQLQGVC PNGECLNTMG SYRCTCKIGF GPDPTFSSCV PDPPVISEEK
360 370 380 390 400
GPCYRLVSSG RQCMHPLSVH LTKQLCCCSV GKAWGPHCEK CPLPGTAAFK
410 420 430 440 450
EICPGGMGYT VSGVHRRRPI HHHVGKGPVF VKPKNTQPVA KSTHPPPLPA
460 470 480 490 500
KEEPVEALTF SREHGPGVAE PEVATAPPEK EIPSLDQEKT KLEPGQPQLS
510 520 530 540 550
PDISTIHLHP QFPVVIEKTS PPVPVEVAPE ASTSSASQVI APTQVTEINE
560 570 580 590 600
CTVNPDICGA GHCINLPVRY TCICYEGYRF SEQQRKCVDI DECTQVQHLC
610 620 630 640 650
SQGRCENTEG SFLCICPAGF MASEEGTNCI DVDECLRPDV CGEGHCVNTV
660 670 680 690 700
GAFRCEYCDS GYRMTQRGRC EDIDECLNPS TCPDEQCVNS PGSYQCVPCT
710 720 730 740 750
EGFRGWNGQC LDVDECLEPN VCANGDCSNL EGSYMCSCHK GYTRTPDHKH
760 770 780 790 800
CRDIDECQQG NLCVNGQCKN TEGSFRCTCG QGYQLSAAKD QCEDIDECQH
810 820 830 840 850
RHLCAHGQCR NTEGSFQCVC DQGYRASGLG DHCEDINECL EDKSVCQRGD
860 870 880 890 900
CINTAGSYDC TCPDGFQLDD NKTCQDINEC EHPGLCGPQG ECLNTEGSFH
910 920 930 940 950
CVCQQGFSIS ADGRTCEDVN ECELLSGVCG EAFCENVEGS FLCVCADENQ
960 970 980 990 1000
EYSPMTGQCR SRTSTDLDVD VDQPKEEKKE CYYNLNDASL CDNVLAPNVT
1010 1020 1030 1040 1050
KQECCCTSGA GWGDNCEIFP CPVLGTAEFT EMCPKGKGFV PAGESSSEAG
1060 1070 1080 1090 1100
GENYKDADEC LLFGQEICKN GFCLNTRPGY ECYCKQGTYY DPVKLQCFDM
1110 1120 1130 1140 1150
DECQDPSSCI DGQCVNTEGS YNCFCTHPMV LDASEKRCIR PAESNEQIEE
1160 1170 1180 1190 1200
TDVYQDLCWE HLSDEYVCSR PLVGKQTTYT ECCCLYGEAW GMQCALCPLK
1210 1220 1230 1240 1250
DSDDYAQLCN IPVTGRRQPY GRDALVDFSE QYTPEADPYF IQDRFLNSFE
1260 1270 1280 1290 1300
ELQAEECGIL NGCENGRCVR VQEGYTCDCF DGYHLDTAKM TCVDVNECDE
1310 1320 1330 1340 1350
LNNRMSLCKN AKCINTDGSY KCLCLPGYVP SDKPNYCTPL NTALNLEKDS

DLE
Length:1,353
Mass (Da):148,464
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E6E816C37B74D2E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC144128 mRNA Translation: AAI44129.1

NCBI Reference Sequences

More...
RefSeqi
NP_001159736.1, NM_001166264.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4052

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144128 mRNA Translation: AAI44129.1
RefSeqiNP_001159736.1, NM_001166264.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiB7ZLY3, 1 interactor

Proteomic databases

PeptideAtlasiB7ZLY3
PRIDEiB7ZLY3

Genome annotation databases

GeneIDi4052

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4052

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4052, 4 hits in 868 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LTBP1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4052

Gene expression databases

GenevisibleiB7ZLY3, HS

Family and domain databases

Gene3Di3.90.290.10, 4 hits
InterProiView protein in InterPro
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR017878, TB_dom
IPR036773, TB_dom_sf
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 12 hits
PF00683, TB, 4 hits
SMARTiView protein in SMART
SM00181, EGF, 16 hits
SM00179, EGF_CA, 15 hits
SUPFAMiSSF57184, SSF57184, 3 hits
SSF57581, SSF57581, 4 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 10 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 12 hits
PS01187, EGF_CA, 6 hits
PS51364, TB, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7ZLY3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7ZLY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: August 12, 2020
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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