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Entry version 61 (31 Jul 2019)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

HELZ protein

Gene

HELZ

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri178 – 206C3H1-typePROSITE-ProRule annotationAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HELZ proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HELZImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B7ZLW2

PeptideAtlas

More...
PeptideAtlasi
B7ZLW2

PRoteomics IDEntifications database

More...
PRIDEi
B7ZLW2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini178 – 206C3H1-typeInterPro annotationAdd BLAST29

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1118 – 1143DisorderedSequence analysisAdd BLAST26
Regioni1247 – 1346DisorderedSequence analysisAdd BLAST100
Regioni1387 – 1430DisorderedSequence analysisAdd BLAST44
Regioni1528 – 1553DisorderedSequence analysisAdd BLAST26
Regioni1609 – 1642DisorderedSequence analysisAdd BLAST34
Regioni1730 – 1780DisorderedSequence analysisAdd BLAST51
Regioni1793 – 1844DisorderedSequence analysisAdd BLAST52
Regioni1871 – 1943DisorderedSequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1118 – 1133PolarSequence analysisAdd BLAST16
Compositional biasi1308 – 1325PolarSequence analysisAdd BLAST18
Compositional biasi1387 – 1414PolarSequence analysisAdd BLAST28
Compositional biasi1624 – 1642PolarSequence analysisAdd BLAST19
Compositional biasi1732 – 1746PolarSequence analysisAdd BLAST15
Compositional biasi1760 – 1780PolarSequence analysisAdd BLAST21
Compositional biasi1793 – 1827PolarSequence analysisAdd BLAST35
Compositional biasi1875 – 1893PolarSequence analysisAdd BLAST19
Compositional biasi1918 – 1943PolarSequence analysisAdd BLAST26

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri178 – 206C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1804 Eukaryota
COG1112 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231202

Database of Orthologous Groups

More...
OrthoDBi
286011at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR006935 Helicase/UvrB_N
IPR027417 P-loop_NTPase
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13086 AAA_11, 1 hit
PF13087 AAA_12, 1 hit
PF04851 ResIII, 1 hit
PF00642 zf-CCCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00356 ZnF_C3H1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF90229 SSF90229, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103 ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7ZLW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDRRAEKSC EQACESLKRQ DYEMALKHCT EALLSLGQYS MADFTGPCPL
60 70 80 90 100
EIERIKIESL LYRIASFLQL KNYMQADEDC RHVLGEGLAK GEDAFRAVLC
110 120 130 140 150
CMQLKGKLQP VSTILAKSLT GESLNGMVTK DLTRLKTLLS ETETATSNAL
160 170 180 190 200
SGYHVEDLDE GSCNGWHFRP PPRGITSSEE YTLCKRFLEQ GICRYGAQCT
210 220 230 240 250
SAHSQEELAE WQKRYASRLI KLKQQNENKQ LSGSYMETLI EKWMNSLSPE
260 270 280 290 300
KVLSECIEGV KVEHNPDLSV TVSTKKSHQT WTFALTCKPA RMLYRVALLY
310 320 330 340 350
DAHRPHFSII AISAGDSTTQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG
360 370 380 390 400
IAFNTEIFGT FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKQQLV
410 420 430 440 450
TTAKRWDSSS KTIIDFEPNE TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS
460 470 480 490 500
LTKSNYQSRL HDLLYIEEIA QYKEISKFNL KVQLQILASF MLTGVSGGAK
510 520 530 540 550
YAQNGQLFGR FKLTETLSED TLAGRLVMTK VNAVYLLPVP KQKLVQTQGT
560 570 580 590 600
KEKVYEATIE EKTKEYIFLR LSRECCEELN LRPDCDTQVE LQFQLNRLPL
610 620 630 640 650
CEMHYALDRI KDNGVLFPDI SMTPTIPWSP NRQWDEQLDP RLNAKQKEAV
660 670 680 690 700
LAITTPLAIQ LPPVLIIGPY GTGKTFTLAQ AVKHILQQQE TSRILICTHS
710 720 730 740 750
NSAADLYIKD YLHPYVEAGN PQARPLRVYF RNRWVKTVHP VVHQYCLISS
760 770 780 790 800
AHSTFQMPQK EDILKHRVVV VTLNTSQYLC QLDLEPGFFT HILLDEAAQA
810 820 830 840 850
MECETIMPLA LATQNTRIVL AGDHMQLSPF VYSEFARERN LHVSLLDRLY
860 870 880 890 900
EHYPAEFPCR ILLCENYRSH EAIINYTSEL FYEGKLMASG KQPAHKDFYP
910 920 930 940 950
LTFFTARGED VQEKNSTAFY NNAEVFEVVE RVEELRRKWP VAWGKLDDGS
960 970 980 990 1000
IGVVTPYADQ VFRIRAELRK KRLSDVNVER VLNVQGKQFR VLFLSTVRTR
1010 1020 1030 1040 1050
HTCKHKQTPI KKKEQLLEDS TEDLDYGFLS NYKLLNTAIT RAQSLVAVVG
1060 1070 1080 1090 1100
DPIALCSIGR CRKFWERFIA LCHENSSLHG ITFEQIKAQL EALELKKTYV
1110 1120 1130 1140 1150
LNPLAPEFIP RALRLQHSGS TNKQQQSPPK GKSLHHTQND HFQNDGIVQP
1160 1170 1180 1190 1200
NPSVLIGNPI RAYTPPPPLG PHPNLGKSPS PVQRIDPHTG TSILYVPAVY
1210 1220 1230 1240 1250
GGNVVMSVPL PVPWTGYQGR FAVDPRIITH QAAMAYNMNL LQTHGRGSPI
1260 1270 1280 1290 1300
PYGLGHHPPV TIGQPQNQHQ EKDQHEQNRN GKSDTNNSGP EINKIRTPEK
1310 1320 1330 1340 1350
KPTEPKQVDL ESNPQNRSPE SRPSVVYPST KFPRKDNLNP RHINLPLPAP
1360 1370 1380 1390 1400
HAQYAIPNRH FHPLPQLPRP PFPIPQQHTL LNQQQNNLPE QPNQIPPQPN
1410 1420 1430 1440 1450
QVVQQQSQLN QQPQQPPPQL SPAYQAGPNN AFFNSAVAHR PQSPPAEAVI
1460 1470 1480 1490 1500
PEQQPPPMLQ EGHSPLRAIA QPGPILPSHL NSFIDENPSG LPIGEALDRI
1510 1520 1530 1540 1550
HGSVALETLR QQQARFQQWS EHHAFLSQGS VPYPHHHHPH LQHLPQPPLG
1560 1570 1580 1590 1600
LHQPPVRADW KLTSSAEDEV ETTYSRFQDL IRELSHRDQS ETRELAEMPP
1610 1620 1630 1640 1650
PQSRLLQYRQ VQSRSPPAVP SPPSSTDHSS HFSNFNDNSR DIEVASNPAF
1660 1670 1680 1690 1700
PQRLPPQIFN SPFSLPSEHL APPPLKYLAP DGAWTFANLQ QNHLMGPGFP
1710 1720 1730 1740 1750
YGLPPLPHRP PQNPFVQIQN HQHAIGQEPF HPLSSRTVSS SSLPSLEEYE
1760 1770 1780 1790 1800
PRGPGRPLYQ RRISSSSVQP CSEEVSTPQD SLAQCKELQD HSNQSSFNFS
1810 1820 1830 1840 1850
SPESWVNTTS STPYQNIPCN GSSRTAQPRE LIAPPKTVKP PEDQLKSENL
1860 1870 1880 1890 1900
EVSSSFNYSV LQHLGQFPPL MPNKQIAESA NSSSPQSSAG GKPAMSYASA
1910 1920 1930 1940
LRAPPKPRPP PEQAKKSSDP LSLFQELSLG SSSGSNGFYS YFK
Length:1,943
Mass (Da):219,117
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BE4254EBE3B3AB8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC144083 mRNA Translation: AAI44084.1

NCBI Reference Sequences

More...
RefSeqi
NP_001317376.1, NM_001330447.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9931

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144083 mRNA Translation: AAI44084.1
RefSeqiNP_001317376.1, NM_001330447.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiB7ZLW2
PeptideAtlasiB7ZLW2
PRIDEiB7ZLW2

Genome annotation databases

GeneIDi9931

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9931

Phylogenomic databases

eggNOGiKOG1804 Eukaryota
COG1112 LUCA
HOGENOMiHOG000231202
OrthoDBi286011at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HELZ human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9931

Family and domain databases

InterProiView protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR006935 Helicase/UvrB_N
IPR027417 P-loop_NTPase
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF13086 AAA_11, 1 hit
PF13087 AAA_12, 1 hit
PF04851 ResIII, 1 hit
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7ZLW2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7ZLW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 31, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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