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Protein
Submitted name:

SEZ6L protein

Gene

SEZ6L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
SEZ6L proteinImported
Submitted name:
Seizure 6-like proteinImported
Gene namesi
Name:SEZ6LImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100095.18
HGNCiHGNC:10763 SEZ6L

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei944 – 966HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100095
PharmGKBiPA35681

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501430019929 – 1011Sequence analysisAdd BLAST983

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi281 ↔ 308PROSITE-ProRule annotation
Disulfide bondi452 ↔ 479PROSITE-ProRule annotation
Disulfide bondi773 ↔ 800PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000100095 Expressed in 107 organ(s), highest expression level in forebrain

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 389CUBInterPro annotationAdd BLAST109
Domaini391 – 450SushiInterPro annotationAdd BLAST60
Domaini452 – 562CUBInterPro annotationAdd BLAST111
Domaini565 – 626SushiInterPro annotationAdd BLAST62
Domaini628 – 739CUBInterPro annotationAdd BLAST112
Domaini743 – 802SushiInterPro annotationAdd BLAST60
Domaini804 – 867SushiInterPro annotationAdd BLAST64
Domaini871 – 932SushiInterPro annotationAdd BLAST62

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IJTP Eukaryota
ENOG410ZD9C LUCA
GeneTreeiENSGT00760000118803
HOVERGENiHBG057885

Family and domain databases

CDDicd00033 CCP, 5 hits
cd00041 CUB, 3 hits
Gene3Di2.60.120.290, 3 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00084 Sushi, 5 hits
SMARTiView protein in SMART
SM00032 CCP, 5 hits
SM00042 CUB, 3 hits
SUPFAMiSSF49854 SSF49854, 3 hits
SSF57535 SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 3 hits
PS50923 SUSHI, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

B7ZLJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAARPPAAG LRGISLFLAL LLGSPAAALE RDALPEGDAS PLGPYLLPSG
60 70 80 90 100
APERGSPGKE HPEERVVTAP PSSSQSAEVL GELVLDGTAP SAHHDIPALS
110 120 130 140 150
PLLPEEARPK HALPPKKKLP SLKQVNSARK QLRPKATSAA TVQRAGSQPA
160 170 180 190 200
SQGLDLLSSS TEKPGPPGDP DPIVASEEAS EVPLWLDRKE SAVPTTPAPL
210 220 230 240 250
QISPFTSQPY VAHTLPQRPE PGEPGPDMAQ EAPQEDTSPM ALMDKGENEL
260 270 280 290 300
TGSASEESQE TTTSTIITTT VITTEQAPAL CSVSFSNPEG YIDSSDYPLL
310 320 330 340 350
PLNNFLECTY NVTVYTGYGV ELQVKSVNLS DGELLSIRGV DGPTLTVLAN
360 370 380 390 400
QTLLVEGQVI RSPTNTISVY FRTFQDDGLG TFQLHYQAFM LSCNFPRRPD
410 420 430 440 450
SGDVTVMDLH SGGVAHFHCH LGYELQGAKM LTCINASKPH WSSQEPICSA
460 470 480 490 500
PCGGAVHNAT IGRVLSPSYP ENTNGSQFCI WTIEAPEGQK LHLHFERLLL
510 520 530 540 550
HDKDRMTVHS GQTNKSALLY DSLQTESVPF EGLLSEGNTI RIEFTSDQAR
560 570 580 590 600
AASTFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL
610 620 630 640 650
EQGPAIIECI NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE
660 670 680 690 700
GEDCIWKIHV GEEKRIFLDI QFLNLSNSDI LTIYDGDEVM PHILGQYLGN
710 720 730 740 750
SGPQKLYSST PDLTIQFHSD PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE
760 770 780 790 800
IQNGWKTTSH TELVRGARIT YQCDPGYDIV GSDTLTCQWD LSWSSDPPFC
810 820 830 840 850
EKIMYCTDPG EVDHSTRLIS DPVLLVGTTI QYTCNPGFVL EGSSLLTCYS
860 870 880 890 900
RETGTPIWTS RLPHCVSEES LACDNPGLPE NGYQILYKRL YLPGESLTFM
910 920 930 940 950
CYEGFELMGE VTIRCILGQP SHWNGPLPVC KEAAAETSLE GGNMALAIFI
960 970 980 990 1000
PVLIISLLLG GAYIYITRCR YYSNLRLPLM YSHPYSQITV ETEFDNPIYE
1010
TGETREYEVS I
Length:1,011
Mass (Da):110,341
Last modified:March 3, 2009 - v1
Checksum:i5646860FA2A83B19
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BYH1SE6L1_HUMAN
Seizure 6-like protein
SEZ6L KIAA0927, UNQ2542/PRO6094
1,024Annotation score:
B0QYH4B0QYH4_HUMAN
Seizure 6-like protein
SEZ6L
720Annotation score:
B0QYH5B0QYH5_HUMAN
Seizure 6-like protein
SEZ6L
796Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022337 Genomic DNA No translation available.
AL023513 Genomic DNA No translation available.
AL078460 Genomic DNA No translation available.
AL080273 Genomic DNA No translation available.
KF457391 Genomic DNA No translation available.
KF457392 Genomic DNA No translation available.
BC143854 mRNA Translation: AAI43855.1
RefSeqiNP_001171704.1, NM_001184775.1
UniGeneiHs.194766

Genome annotation databases

EnsembliENST00000529632; ENSP00000437037; ENSG00000100095
GeneIDi23544
UCSCiuc011akd.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022337 Genomic DNA No translation available.
AL023513 Genomic DNA No translation available.
AL078460 Genomic DNA No translation available.
AL080273 Genomic DNA No translation available.
KF457391 Genomic DNA No translation available.
KF457392 Genomic DNA No translation available.
BC143854 mRNA Translation: AAI43855.1
RefSeqiNP_001171704.1, NM_001184775.1
UniGeneiHs.194766

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi23544
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000529632; ENSP00000437037; ENSG00000100095
GeneIDi23544
UCSCiuc011akd.2 human

Organism-specific databases

CTDi23544
EuPathDBiHostDB:ENSG00000100095.18
HGNCiHGNC:10763 SEZ6L
OpenTargetsiENSG00000100095
PharmGKBiPA35681
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJTP Eukaryota
ENOG410ZD9C LUCA
GeneTreeiENSGT00760000118803
HOVERGENiHBG057885

Miscellaneous databases

ChiTaRSiSEZ6L human
GenomeRNAii23544

Gene expression databases

BgeeiENSG00000100095 Expressed in 107 organ(s), highest expression level in forebrain

Family and domain databases

CDDicd00033 CCP, 5 hits
cd00041 CUB, 3 hits
Gene3Di2.60.120.290, 3 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00084 Sushi, 5 hits
SMARTiView protein in SMART
SM00032 CCP, 5 hits
SM00042 CUB, 3 hits
SUPFAMiSSF49854 SSF49854, 3 hits
SSF57535 SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 3 hits
PS50923 SUSHI, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiB7ZLJ8_HUMAN
AccessioniPrimary (citable) accession number: B7ZLJ8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 10, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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