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Protein
Submitted name:

EVPL protein

Gene

EVPL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
EVPL proteinImported
Gene namesi
Name:EVPLImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiB7ZLH8
PeptideAtlasiB7ZLH8
PRIDEiB7ZLH8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini413 – 470SH3InterPro annotationAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili43 – 70Sequence analysisAdd BLAST28
Coiled coili87 – 107Sequence analysisAdd BLAST21
Coiled coili112 – 132Sequence analysisAdd BLAST21
Coiled coili175 – 195Sequence analysisAdd BLAST21
Coiled coili335 – 355Sequence analysisAdd BLAST21
Coiled coili378 – 398Sequence analysisAdd BLAST21
Coiled coili478 – 505Sequence analysisAdd BLAST28
Coiled coili581 – 601Sequence analysisAdd BLAST21
Coiled coili875 – 913Sequence analysisAdd BLAST39
Coiled coili936 – 970Sequence analysisAdd BLAST35
Coiled coili1008 – 1028Sequence analysisAdd BLAST21
Coiled coili1075 – 1095Sequence analysisAdd BLAST21
Coiled coili1114 – 1148Sequence analysisAdd BLAST35
Coiled coili1181 – 1201Sequence analysisAdd BLAST21
Coiled coili1232 – 1252Sequence analysisAdd BLAST21
Coiled coili1292 – 1333Sequence analysisAdd BLAST42
Coiled coili1345 – 1379Sequence analysisAdd BLAST35
Coiled coili1417 – 1444Sequence analysisAdd BLAST28
Coiled coili1454 – 1474Sequence analysisAdd BLAST21
Coiled coili1500 – 1534Sequence analysisAdd BLAST35
Coiled coili1565 – 1592Sequence analysisAdd BLAST28
Coiled coili1600 – 1641Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQBQ Eukaryota
ENOG410XRFQ LUCA
HOGENOMiHOG000049180
HOVERGENiHBG018988

Family and domain databases

Gene3Di3.90.1290.10, 1 hit
InterProiView protein in InterPro
IPR030460 Envoplakin
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
PANTHERiPTHR23169:SF7 PTHR23169:SF7, 1 hit
PfamiView protein in Pfam
PF00681 Plectin, 4 hits
SMARTiView protein in SMART
SM00250 PLEC, 8 hits
SM00150 SPEC, 1 hit
SUPFAMiSSF75399 SSF75399, 2 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

B7ZLH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKGLSKGSQ GKGSPKGSPA KGSPKGSPSR HSRAATQELA LLISRMQANA
60 70 80 90 100
DQVERDILET QKRLQQDRLN SEQSQALQHQ QETGRSLKEA EVLLKDLFLD
110 120 130 140 150
VDKARRLKHP QAEEIEKDIK QLHERVTQEC AEYRALYEKM VLPPDVGPRV
160 170 180 190 200
DWARVLEQKQ KQVCAGQYGP GMAELEQQIA EHNILQKEID AYGQQLRSLV
210 220 230 240 250
GPDAATIRSQ YRDLLKAASW RGQSLGSLYT HLQGCTRQLS ALAEQQRRIL
260 270 280 290 300
QQDWSDLMAD PAGVRREYEH FKQHELLSQE QSVNQLEDDG ERMVELRHPA
310 320 330 340 350
VGPIQAHQEA LKMEWQNFLN LCICQETQLQ HVEDYRRFQE EADSVSQTLA
360 370 380 390 400
KLNSNLDAKY SPAPGGPPGA PTELLQQLEA EEKRLAVTER ATGDLQRRSR
410 420 430 440 450
DVAPLPQRRN PPQQPLHVDS ICDWDSGEVQ LLQGERYKLV DNTDPHAWVV
460 470 480 490 500
QGPGGETKRA PAACFCIPAP DPDAVARASR LASELQALKQ KLATVQSRLK
510 520 530 540 550
ASAVESLRPS QQGTQGGPGR GGCGARRSRF RLPTAPSGSD LANPQAQKLL
560 570 580 590 600
TQMTRLDGDL GQIERQVLAW ARAPLSRPTP LEDLEGRIHS HEGTAQRLQS
610 620 630 640 650
LGTEKETAQK ECEAFLSTRP VGPAALQLPV ALNSVKNKFS DVQVLCSLYG
660 670 680 690 700
EKAKAALDLE RQIQDADRVI RGFEATLVQE APIPAEPGAL QERVSELQRQ
710 720 730 740 750
RRELLEQQTC VLRLHRALKA SEHACAALQN NFQEFCQDLP RQQRQVRALT
760 770 780 790 800
DRYHAVGDQL DLREKVVQDA ALTYQQFKNC KDNLSSWLEH LPRSQVRPSD
810 820 830 840 850
GPSQIAYKLQ AQKRLTQEIQ SRERDRATAS HLSQALQAAL QDYELQADTY
860 870 880 890 900
RCSLEPTLAV SAPKRPRVAP LQESIQAQEK NLAKAYTEVA AAQQQLLQQL
910 920 930 940 950
EFARKMLEKK ELSEDIRRTH DAKQGSESPA QAGRESEALK AQLEEERKRV
960 970 980 990 1000
ARVQHELEAQ RSQLLQLRTQ RPLERLEEKE VVEFYRDPQL EGSLSRVKAQ
1010 1020 1030 1040 1050
VEEEGKRRAG LQADLEVAAQ KVVQLESKRK TMQPHLLTKE VTQVERDPGL
1060 1070 1080 1090 1100
DSQAAQLRIQ IQQLRGEDAV ISARLEGLKK ELLALEKREV DVKEKVVVKE
1110 1120 1130 1140 1150
VVKVEKNLEM VKAAQALRLQ MEEDAARRKQ AEEAVAKLQA RIEDLERAIS
1160 1170 1180 1190 1200
SVEPKVIVKE VKKVEQDPGL LQESSRLRSL LEEERTKNAT LARELSDLHS
1210 1220 1230 1240 1250
KYSVVEKQRP KVQLQERVHE IFQVDPETEQ EITRLKAKLQ EMAGKRSGVE
1260 1270 1280 1290 1300
KEVEKLLPDL EVLRAQKPTV EYKEVTQEVV RHERSPEVLR EIDRLKAQLN
1310 1320 1330 1340 1350
ELVNSHGRSQ EQLIRLQGER DEWRRERAKV ETKTVSKEVV RHEKDPVLEK
1360 1370 1380 1390 1400
EAERLRQEVR EAAQKRRAAE DAVYELQSKR LLLERRKPEE KVVVQEVVVT
1410 1420 1430 1440 1450
QKDPKLREEH SRLSGSLDEE VGRRRQLELE VQQLRAGVEE QEGLLSFQED
1460 1470 1480 1490 1500
RSKKLAVERE LRQLTLRIQE LEKRPPTVQE KIIMEEVVKL EKDPDLEKST
1510 1520 1530 1540 1550
EALRWDLDQE KTQVTELNRE CKNLQVQIDV LQKAKSQEKT IYKEVIRVQK
1560 1570 1580 1590 1600
DRVLEDERAR VWEMLNRERT ARQAREEEAR RLRERIDRAE TLGRTWSREE
1610 1620 1630 1640 1650
SELQRARDQA DQECGRLQQE LRALERQKQQ QTLQLQEESK LLSQKTESER
1660 1670 1680 1690 1700
QKAAQRGQEL SRLEAAILRE KDQIYEKERT LRDLHAKVSR EELSQETQTR
1710 1720 1730 1740 1750
ETNLSTKISI LEPETGKDMS PYEAYKRGII DRGQYLQLQE LECDWEEVTT
1760 1770 1780 1790 1800
SGPCGEESVL LDRKSGKQYS IEAALRCRRI SKEEYHLYKD GHLPISEFAL
1810 1820 1830 1840 1850
LVAGETKPSS SLSIGSIISK SPLASPAPQS TSFFSSSFSL GLGDDSFPIA
1860 1870 1880 1890 1900
GIYDTTTDNK CSIKTAVAKN MLDPITGQKL LEAQAATGGI VDLLSRERYS
1910 1920 1930 1940 1950
VHKAMERGLI ENTSTQRLLN AQKAFTGIED PVTKKRLSVG EAVQKGWMPR
1960 1970 1980 1990 2000
ESVLPHLQVQ HLTGGLIDPK RTGRIPIQQA LLSGMISEEL AQLLQDESSY
2010 2020 2030 2040 2050
EKDLTDPISK ERLSYKEAMG RCRKDPLSGL LLLPAALEGY RCYRSASPTV

PRSLR
Length:2,055
Mass (Da):233,821
Last modified:March 3, 2009 - v1
Checksum:i88E727275A804307
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC143814 mRNA Translation: AAI43815.1
RefSeqiNP_001307676.1, NM_001320747.1
UniGeneiHs.500635

Genome annotation databases

GeneIDi2125

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC143814 mRNA Translation: AAI43815.1
RefSeqiNP_001307676.1, NM_001320747.1
UniGeneiHs.500635

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiB7ZLH8
PeptideAtlasiB7ZLH8
PRIDEiB7ZLH8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2125

Organism-specific databases

CTDi2125

Phylogenomic databases

eggNOGiENOG410IQBQ Eukaryota
ENOG410XRFQ LUCA
HOGENOMiHOG000049180
HOVERGENiHBG018988

Miscellaneous databases

ChiTaRSiEVPL human

Family and domain databases

Gene3Di3.90.1290.10, 1 hit
InterProiView protein in InterPro
IPR030460 Envoplakin
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
PANTHERiPTHR23169:SF7 PTHR23169:SF7, 1 hit
PfamiView protein in Pfam
PF00681 Plectin, 4 hits
SMARTiView protein in SMART
SM00250 PLEC, 8 hits
SM00150 SPEC, 1 hit
SUPFAMiSSF75399 SSF75399, 2 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB7ZLH8_HUMAN
AccessioniPrimary (citable) accession number: B7ZLH8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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