UniProtKB - B7ZLG1 (B7ZLG1_HUMAN)
Protein
Submitted name:
FOXP3 protein
Gene
FOXP3
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 360 – 446 | Fork-headPROSITE-ProRule annotationAdd BLAST | 87 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation, RepressorARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: FOXP3 proteinImportedSubmitted name: Forkhead box protein P3Imported |
Gene namesi | Name:FOXP3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000049768.14 |
HGNCi | HGNC:6106, FOXP3 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000049768, Expressed in amniotic fluid and 134 other tissues |
ExpressionAtlasi | B7ZLG1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 360 – 446 | Fork-headInterPro annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 68 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 171 – 201 | DisorderedSequence analysisAdd BLAST | 31 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 262 – 282 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 53 – 67 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000161807 |
HOGENOMi | CLU_019502_1_0_1 |
OrthoDBi | 836427at2759 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
B7ZLG1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPNPRPGKPS APSLALGPSP GASPSWRAAP KASDLLGARG PGGTFQGRDL
60 70 80 90 100
RGGAHASSSS LNPMPPSQLQ LPTLPLVMVA PSGARLGPLP HLQALLQDRP
110 120 130 140 150
HFMHQLSTVD AHARTPVLQV HPLESPAMIS LTPPTTATGV FSLKARPGLP
160 170 180 190 200
PGINVASLEW VSREPALLCT FPNPSAPRKD RSVDRAGKDP RPPIPSPDTL
210 220 230 240 250
CPPSTLSAVP QSSYPLLANG VCKWPGCEKV FEEPEDFLKH CQADHLLDEK
260 270 280 290 300
GRAQCLLQRE MVQSLEQQLV LEKEKLSAMQ AHLAGKMALT KASSVASSDK
310 320 330 340 350
GSCCIVAAGS QGPVVPAWSG PREAPDSLFA VRRHLWGSHG NSTFPEFLHN
360 370 380 390 400
MDYFKFHNMR PPFTYATLIR WAILEAPEKQ RTLNEIYHWF TRMFAFFRNH
410 420 430 440 450
PATWKNAIRH NLSLHKCFVR VESEKGAVWT VDELEFRKKR SQRPSRCSNP
TPGP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BZS1 | FOXP3_HUMAN | Forkhead box protein P3 | FOXP3 IPEX, JM2 | 431 | Annotation score: | ||
A0A0C4DFW6 | A0A0C4DFW6_HUMAN | Forkhead box P3, isoform CRA_b | FOXP3 hCG_19830 | 441 | Annotation score: | ||
A0A494C0B0 | A0A494C0B0_HUMAN | Forkhead box protein P3 | FOXP3 | 335 | Annotation score: | ||
A0A494BZV0 | A0A494BZV0_HUMAN | Forkhead box protein P3 | FOXP3 | 154 | Annotation score: | ||
A0A494C1K1 | A0A494C1K1_HUMAN | Forkhead box protein P3 | FOXP3 | 54 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC232271 Genomic DNA No translation available. BC143786 mRNA Translation: AAI43787.1 |
RefSeqi | XP_006724596.2, XM_006724533.2 |
Genome annotation databases
Ensembli | ENST00000455775; ENSP00000396415; ENSG00000049768 |
GeneIDi | 50943 |
UCSCi | uc064zfn.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC232271 Genomic DNA No translation available. BC143786 mRNA Translation: AAI43787.1 |
RefSeqi | XP_006724596.2, XM_006724533.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | B7ZLG1 |
Protocols and materials databases
Antibodypediai | 485, 1867 antibodies |
Genome annotation databases
Ensembli | ENST00000455775; ENSP00000396415; ENSG00000049768 |
GeneIDi | 50943 |
UCSCi | uc064zfn.1, human |
Organism-specific databases
CTDi | 50943 |
EuPathDBi | HostDB:ENSG00000049768.14 |
HGNCi | HGNC:6106, FOXP3 |
OpenTargetsi | ENSG00000049768 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161807 |
HOGENOMi | CLU_019502_1_0_1 |
OrthoDBi | 836427at2759 |
Miscellaneous databases
BioGRID-ORCSi | 50943, 2 hits in 494 CRISPR screens |
GenomeRNAii | 50943 |
Gene expression databases
Bgeei | ENSG00000049768, Expressed in amniotic fluid and 134 other tissues |
ExpressionAtlasi | B7ZLG1, baseline and differential |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7ZLG1_HUMAN | |
Accessioni | B7ZLG1Primary (citable) accession number: B7ZLG1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |