UniProtKB - B7ZLE5 (B7ZLE5_HUMAN)
Protein
Fibronectin
Gene
FN1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- heparin binding Source: UniProtKB-KW
GO - Biological processi
- acute-phase response Source: UniProtKB-KW
- cell adhesion Source: UniProtKB-KW
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Heparin-bindingARBA annotation |
Biological process | Acute phaseARBA annotation, Cell adhesionARBA annotation, Cell shapeARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: FibronectinARBA annotation |
Gene namesi | Name:FN1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5002866941 | 27 – 2240 | FibronectinSequence analysisAdd BLAST | 2214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 360 ↔ 386 | PROSITE-ProRule annotation | ||
Disulfide bondi | 374 ↔ 401 | PROSITE-ProRule annotation | ||
Disulfide bondi | 420 ↔ 446 | PROSITE-ProRule annotation | ||
Disulfide bondi | 434 ↔ 461 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, OxidationARBA annotationProteomic databases
PeptideAtlasi | B7ZLE5 |
Structurei
3D structure databases
SMRi | B7ZLE5 |
ModBasei | Search... |
Miscellaneous databases
EvolutionaryTracei | B7ZLE5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 90 | Fibronectin type-IInterPro annotationAdd BLAST | 41 | |
Domaini | 95 – 138 | Fibronectin type-IInterPro annotationAdd BLAST | 44 | |
Domaini | 139 – 182 | Fibronectin type-IInterPro annotationAdd BLAST | 44 | |
Domaini | 184 – 228 | Fibronectin type-IInterPro annotationAdd BLAST | 45 | |
Domaini | 229 – 273 | Fibronectin type-IInterPro annotationAdd BLAST | 45 | |
Domaini | 306 – 345 | Fibronectin type-IInterPro annotationAdd BLAST | 40 | |
Domaini | 355 – 403 | Fibronectin type-IIInterPro annotationAdd BLAST | 49 | |
Domaini | 415 – 463 | Fibronectin type-IIInterPro annotationAdd BLAST | 49 | |
Domaini | 468 – 511 | Fibronectin type-IInterPro annotationAdd BLAST | 44 | |
Domaini | 516 – 558 | Fibronectin type-IInterPro annotationAdd BLAST | 43 | |
Domaini | 559 – 602 | Fibronectin type-IInterPro annotationAdd BLAST | 44 | |
Domaini | 610 – 702 | Fibronectin type-IIIInterPro annotationAdd BLAST | 93 | |
Domaini | 722 – 812 | Fibronectin type-IIIInterPro annotationAdd BLAST | 91 | |
Domaini | 813 – 904 | Fibronectin type-IIIInterPro annotationAdd BLAST | 92 | |
Domaini | 909 – 998 | Fibronectin type-IIIInterPro annotationAdd BLAST | 90 | |
Domaini | 999 – 1088 | Fibronectin type-IIIInterPro annotationAdd BLAST | 90 | |
Domaini | 1089 – 1175 | Fibronectin type-IIIInterPro annotationAdd BLAST | 87 | |
Domaini | 1176 – 1266 | Fibronectin type-IIIInterPro annotationAdd BLAST | 91 | |
Domaini | 1269 – 1361 | Fibronectin type-IIIInterPro annotationAdd BLAST | 93 | |
Domaini | 1362 – 1449 | Fibronectin type-IIIInterPro annotationAdd BLAST | 88 | |
Domaini | 1450 – 1543 | Fibronectin type-IIIInterPro annotationAdd BLAST | 94 | |
Domaini | 1544 – 1634 | Fibronectin type-IIIInterPro annotationAdd BLAST | 91 | |
Domaini | 1635 – 1727 | Fibronectin type-IIIInterPro annotationAdd BLAST | 93 | |
Domaini | 1728 – 1814 | Fibronectin type-IIIInterPro annotationAdd BLAST | 87 | |
Domaini | 1815 – 1908 | Fibronectin type-IIIInterPro annotationAdd BLAST | 94 | |
Domaini | 1959 – 2051 | Fibronectin type-IIIInterPro annotationAdd BLAST | 93 | |
Domaini | 2058 – 2102 | Fibronectin type-IInterPro annotationAdd BLAST | 45 | |
Domaini | 2103 – 2145 | Fibronectin type-IInterPro annotationAdd BLAST | 43 | |
Domaini | 2147 – 2187 | Fibronectin type-IInterPro annotationAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 48 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1569 – 1593 | DisorderedSequence analysisAdd BLAST | 25 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
OrthoDBi | 6580at2759 |
Family and domain databases
CDDi | cd00061, FN1, 12 hits cd00062, FN2, 2 hits cd00063, FN3, 15 hits |
Gene3Di | 2.10.10.10, 2 hits 2.60.40.10, 15 hits |
InterProi | View protein in InterPro IPR000083, Fibronectin_type1 IPR003961, FN3_dom IPR036116, FN3_sf IPR000562, FN_type2_dom IPR036943, FN_type2_sf IPR013783, Ig-like_fold IPR013806, Kringle-like |
Pfami | View protein in Pfam PF00039, fn1, 12 hits PF00040, fn2, 2 hits PF00041, fn3, 15 hits |
SMARTi | View protein in SMART SM00058, FN1, 12 hits SM00059, FN2, 2 hits SM00060, FN3, 15 hits |
SUPFAMi | SSF49265, SSF49265, 9 hits SSF57440, SSF57440, 2 hits |
PROSITEi | View protein in PROSITE PS01253, FN1_1, 6 hits PS51091, FN1_2, 12 hits PS00023, FN2_1, 1 hit PS51092, FN2_2, 2 hits PS50853, FN3, 15 hits |
i Sequence
Sequence statusi: Complete.
B7ZLE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRGPGPGLL LLAVQCLGTA VPSTGASKSK RQAQQMVQPQ SPVAVSQSKP
60 70 80 90 100
GCYDNGKHYQ INQQWERTYL GNALVCTCYG GSRGFNCESK PEAEETCFDK
110 120 130 140 150
YTGNTYRVGD TYERPKDSMI WDCTCIGAGR GRISCTIANR CHEGGQSYKI
160 170 180 190 200
GDTWRRPHET GGYMLECVCL GNGKGEWTCK PIAEKCFDHA AGTSYVVGET
210 220 230 240 250
WEKPYQGWMM VDCTCLGEGS GRITCTSRNR CNDQDTRTSY RIGDTWSKKD
260 270 280 290 300
NRGNLLQCIC TGNGRGEWKC ERHTSVQTTS SGSGPFTDVR AAVYQPQPHP
310 320 330 340 350
QPPPYGHCVT DSGVVYSVGM QWLKTQGNKQ MLCTCLGNGV SCQETAVTQT
360 370 380 390 400
YGGNSNGEPC VLPFTYNGRT FYSCTTEGRQ DGHLWCSTTS NYEQDQKYSF
410 420 430 440 450
CTDHTVLVQT RGGNSNGALC HFPFLYNNHN YTDCTSEGRR DNMKWCGTTQ
460 470 480 490 500
NYDADQKFGF CPMAAHEEIC TTNEGVMYRI GDQWDKQHDM GHMMRCTCVG
510 520 530 540 550
NGRGEWTCIA YSQLRDQCIV DDITYNVNDT FHKRHEEGHM LNCTCFGQGR
560 570 580 590 600
GRWKCDPVDQ CQDSETGTFY QIGDSWEKYV HGVRYQCYCY GRGIGEWHCQ
610 620 630 640 650
PLQTYPSSSG PVEVFITETP SQPNSHPIQW NAPQPSHISK YILRWRPKNS
660 670 680 690 700
VGRWKEATIP GHLNSYTIKG LKPGVVYEGQ LISIQQYGHQ EVTRFDFTTT
710 720 730 740 750
STSTPVTSNT VTGETTPFSP LVATSESVTE ITASSFVVSW VSASDTVSGF
760 770 780 790 800
RVEYELSEEG DEPQYLDLPS TATSVNIPDL LPGRKYIVNV YQISEDGEQS
810 820 830 840 850
LILSTSQTTA PDAPPDPTVD QVDDTSIVVR WSRPQAPITG YRIVYSPSVE
860 870 880 890 900
GSSTELNLPE TANSVTLSDL QPGVQYNITI YAVEENQEST PVVIQQETTG
910 920 930 940 950
TPRSDTVPSP RDLQFVEVTD VKVTIMWTPP ESAVTGYRVD VIPVNLPGEH
960 970 980 990 1000
GQRLPISRNT FAEVTGLSPG VTYYFKVFAV SHGRESKPLT AQQTTKLDAP
1010 1020 1030 1040 1050
TNLQFVNETD STVLVRWTPP RAQITGYRLT VGLTRRGQPR QYNVGPSVSK
1060 1070 1080 1090 1100
YPLRNLQPAS EYTVSLVAIK GNQESPKATG VFTTLQPGSS IPPYNTEVTE
1110 1120 1130 1140 1150
TTIVITWTPA PRIGFKLGVR PSQGGEAPRE VTSDSGSIVV SGLTPGVEYV
1160 1170 1180 1190 1200
YTIQVLRDGQ ERDAPIVNKV VTPLSPPTNL HLEANPDTGV LTVSWERSTT
1210 1220 1230 1240 1250
PDITGYRITT TPTNGQQGNS LEEVVHADQS SCTFDNLSPG LEYNVSVYTV
1260 1270 1280 1290 1300
KDDKESVPIS DTIIPAVPPP TDLRFTNIGP DTMRVTWAPP PSIDLTNFLV
1310 1320 1330 1340 1350
RYSPVKNEED VAELSISPSD NAVVLTNLLP GTEYVVSVSS VYEQHESTPL
1360 1370 1380 1390 1400
RGRQKTGLDS PTGIDFSDIT ANSFTVHWIA PRATITGYRI RHHPEHFSGR
1410 1420 1430 1440 1450
PREDRVPHSR NSITLTNLTP GTEYVVSIVA LNGREESPLL IGQQSTVSDV
1460 1470 1480 1490 1500
PRDLEVVAAT PTSLLISWDA PAVTVRYYRI TYGETGGNSP VQEFTVPGSK
1510 1520 1530 1540 1550
STATISGLKP GVDYTITVYA VTGRGDSPAS SKPISINYRT EIDKPSQMQV
1560 1570 1580 1590 1600
TDVQDNSISV KWLPSSSPVT GYRVTTTPKN GPGPTKTKTA GPDQTEMTIE
1610 1620 1630 1640 1650
GLQPTVEYVV SVYAQNPSGE SQPLVQTAVT TIPAPTDLKF TQVTPTSLSA
1660 1670 1680 1690 1700
QWTPPNVQLT GYRVRVTPKE KTGPMKEINL APDSSSVVVS GLMVATKYEV
1710 1720 1730 1740 1750
SVYALKDTLT SRPAQGVVTT LENVSPPRRA RVTDATETTI TISWRTKTET
1760 1770 1780 1790 1800
ITGFQVDAVP ANGQTPIQRT IKPDVRSYTI TGLQPGTDYK IYLYTLNDNA
1810 1820 1830 1840 1850
RSSPVVIDAS TAIDAPSNLR FLATTPNSLL VSWQPPRARI TGYIIKYEKP
1860 1870 1880 1890 1900
GSPPREVVPR PRPGVTEATI TGLEPGTEYT IYVIALKNNQ KSEPLIGRKK
1910 1920 1930 1940 1950
TVQKTPFVTH PGYDTGNGIQ LPGTSGQQPS VGQQMIFEEH GFRRTTPPTT
1960 1970 1980 1990 2000
ATPIRHRPRP YPPNVGQEAL SQTTISWAPF QDTSEYIISC HPVGTDEEPL
2010 2020 2030 2040 2050
QFRVPGTSTS ATLTGLTRGA TYNIIVEALK DQQRHKVREE VVTVGNSVNE
2060 2070 2080 2090 2100
GLNQPTDDSC FDPYTVSHYA VGDEWERMSE SGFKLLCQCL GFGSGHFRCD
2110 2120 2130 2140 2150
SSRWCHDNGV NYKIGEKWDR QGENGQMMSC TCLGNGKGEF KCDPHEATCY
2160 2170 2180 2190 2200
DDGKTYHVGE QWQKEYLGAI CSCTCFGGQR GWRCDNCRRP GGEPSPEGTT
2210 2220 2230 2240
GQSYNQYSQR YHQRTNTNVN CPIECFMPLD VQADREDSRE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC143754 mRNA Translation: AAI43755.1 |
RefSeqi | NP_001293058.1, NM_001306129.1 NP_001293059.1, NM_001306130.1 NP_001293061.1, NM_001306132.1 |
Genome annotation databases
GeneIDi | 2335 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC143754 mRNA Translation: AAI43755.1 |
RefSeqi | NP_001293058.1, NM_001306129.1 NP_001293059.1, NM_001306130.1 NP_001293061.1, NM_001306132.1 |
3D structure databases
SMRi | B7ZLE5 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | B7ZLE5 |
Genome annotation databases
GeneIDi | 2335 |
Organism-specific databases
CTDi | 2335 |
Phylogenomic databases
OrthoDBi | 6580at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2335, 5 hits in 845 CRISPR screens |
ChiTaRSi | FN1, human |
EvolutionaryTracei | B7ZLE5 |
GenomeRNAii | 2335 |
Family and domain databases
CDDi | cd00061, FN1, 12 hits cd00062, FN2, 2 hits cd00063, FN3, 15 hits |
Gene3Di | 2.10.10.10, 2 hits 2.60.40.10, 15 hits |
InterProi | View protein in InterPro IPR000083, Fibronectin_type1 IPR003961, FN3_dom IPR036116, FN3_sf IPR000562, FN_type2_dom IPR036943, FN_type2_sf IPR013783, Ig-like_fold IPR013806, Kringle-like |
Pfami | View protein in Pfam PF00039, fn1, 12 hits PF00040, fn2, 2 hits PF00041, fn3, 15 hits |
SMARTi | View protein in SMART SM00058, FN1, 12 hits SM00059, FN2, 2 hits SM00060, FN3, 15 hits |
SUPFAMi | SSF49265, SSF49265, 9 hits SSF57440, SSF57440, 2 hits |
PROSITEi | View protein in PROSITE PS01253, FN1_1, 6 hits PS51091, FN1_2, 12 hits PS00023, FN2_1, 1 hit PS51092, FN2_2, 2 hits PS50853, FN3, 15 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7ZLE5_HUMAN | |
Accessioni | B7ZLE5Primary (citable) accession number: B7ZLE5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | December 2, 2020 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |