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UniProtKB - B7ZLE5 (B7ZLE5_HUMAN)

Entry version 69 (07 Oct 2020)
Sequence version 1 (03 Mar 2009)
Previous versions | rss
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Protein

Fibronectin

Gene

FN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-bindingARBA annotation
Biological processAcute phaseARBA annotation, Cell adhesionARBA annotation, Cell shapeARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FibronectinARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FN1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500286694127 – 2240FibronectinSequence analysisAdd BLAST2214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi360 ↔ 386PROSITE-ProRule annotation
Disulfide bondi374 ↔ 401PROSITE-ProRule annotation
Disulfide bondi420 ↔ 446PROSITE-ProRule annotation
Disulfide bondi434 ↔ 461PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation, OxidationARBA annotation

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		B7ZLE5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		B7ZLE5

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		B7ZLE5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 90Fibronectin type-IInterPro annotationAdd BLAST41
Domaini95 – 138Fibronectin type-IInterPro annotationAdd BLAST44
Domaini139 – 182Fibronectin type-IInterPro annotationAdd BLAST44
Domaini184 – 228Fibronectin type-IInterPro annotationAdd BLAST45
Domaini229 – 273Fibronectin type-IInterPro annotationAdd BLAST45
Domaini306 – 345Fibronectin type-IInterPro annotationAdd BLAST40
Domaini355 – 403Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini415 – 463Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini468 – 511Fibronectin type-IInterPro annotationAdd BLAST44
Domaini516 – 558Fibronectin type-IInterPro annotationAdd BLAST43
Domaini559 – 602Fibronectin type-IInterPro annotationAdd BLAST44
Domaini610 – 702Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini722 – 812Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini813 – 904Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini909 – 998Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini999 – 1088Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1089 – 1175Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1176 – 1266Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini1269 – 1361Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini1362 – 1449Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini1450 – 1543Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1544 – 1634Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini1635 – 1727Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini1728 – 1814Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1815 – 1908Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1959 – 2051Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini2058 – 2102Fibronectin type-IInterPro annotationAdd BLAST45
Domaini2103 – 2145Fibronectin type-IInterPro annotationAdd BLAST43
Domaini2147 – 2187Fibronectin type-IInterPro annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 48DisorderedSequence analysisAdd BLAST22
Regioni1569 – 1593DisorderedSequence analysisAdd BLAST25

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		6580at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00061, FN1, 12 hits
cd00062, FN2, 2 hits
cd00063, FN3, 15 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.10.10, 2 hits
2.60.40.10, 15 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000083, Fibronectin_type1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013783, Ig-like_fold
IPR013806, Kringle-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00039, fn1, 12 hits
PF00040, fn2, 2 hits
PF00041, fn3, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00058, FN1, 12 hits
SM00059, FN2, 2 hits
SM00060, FN3, 15 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 9 hits
SSF57440, SSF57440, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01253, FN1_1, 6 hits
PS51091, FN1_2, 12 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 2 hits
PS50853, FN3, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7ZLE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRGPGPGLL LLAVQCLGTA VPSTGASKSK RQAQQMVQPQ SPVAVSQSKP 
        60         70         80         90        100
GCYDNGKHYQ INQQWERTYL GNALVCTCYG GSRGFNCESK PEAEETCFDK 
       110        120        130        140        150
YTGNTYRVGD TYERPKDSMI WDCTCIGAGR GRISCTIANR CHEGGQSYKI 
       160        170        180        190        200
GDTWRRPHET GGYMLECVCL GNGKGEWTCK PIAEKCFDHA AGTSYVVGET 
       210        220        230        240        250
WEKPYQGWMM VDCTCLGEGS GRITCTSRNR CNDQDTRTSY RIGDTWSKKD 
       260        270        280        290        300
NRGNLLQCIC TGNGRGEWKC ERHTSVQTTS SGSGPFTDVR AAVYQPQPHP 
       310        320        330        340        350
QPPPYGHCVT DSGVVYSVGM QWLKTQGNKQ MLCTCLGNGV SCQETAVTQT 
       360        370        380        390        400
YGGNSNGEPC VLPFTYNGRT FYSCTTEGRQ DGHLWCSTTS NYEQDQKYSF 
       410        420        430        440        450
CTDHTVLVQT RGGNSNGALC HFPFLYNNHN YTDCTSEGRR DNMKWCGTTQ 
       460        470        480        490        500
NYDADQKFGF CPMAAHEEIC TTNEGVMYRI GDQWDKQHDM GHMMRCTCVG 
       510        520        530        540        550
NGRGEWTCIA YSQLRDQCIV DDITYNVNDT FHKRHEEGHM LNCTCFGQGR 
       560        570        580        590        600
GRWKCDPVDQ CQDSETGTFY QIGDSWEKYV HGVRYQCYCY GRGIGEWHCQ 
       610        620        630        640        650
PLQTYPSSSG PVEVFITETP SQPNSHPIQW NAPQPSHISK YILRWRPKNS 
       660        670        680        690        700
VGRWKEATIP GHLNSYTIKG LKPGVVYEGQ LISIQQYGHQ EVTRFDFTTT 
       710        720        730        740        750
STSTPVTSNT VTGETTPFSP LVATSESVTE ITASSFVVSW VSASDTVSGF 
       760        770        780        790        800
RVEYELSEEG DEPQYLDLPS TATSVNIPDL LPGRKYIVNV YQISEDGEQS 
       810        820        830        840        850
LILSTSQTTA PDAPPDPTVD QVDDTSIVVR WSRPQAPITG YRIVYSPSVE 
       860        870        880        890        900
GSSTELNLPE TANSVTLSDL QPGVQYNITI YAVEENQEST PVVIQQETTG 
       910        920        930        940        950
TPRSDTVPSP RDLQFVEVTD VKVTIMWTPP ESAVTGYRVD VIPVNLPGEH 
       960        970        980        990       1000
GQRLPISRNT FAEVTGLSPG VTYYFKVFAV SHGRESKPLT AQQTTKLDAP 
      1010       1020       1030       1040       1050
TNLQFVNETD STVLVRWTPP RAQITGYRLT VGLTRRGQPR QYNVGPSVSK 
      1060       1070       1080       1090       1100
YPLRNLQPAS EYTVSLVAIK GNQESPKATG VFTTLQPGSS IPPYNTEVTE 
      1110       1120       1130       1140       1150
TTIVITWTPA PRIGFKLGVR PSQGGEAPRE VTSDSGSIVV SGLTPGVEYV 
      1160       1170       1180       1190       1200
YTIQVLRDGQ ERDAPIVNKV VTPLSPPTNL HLEANPDTGV LTVSWERSTT 
      1210       1220       1230       1240       1250
PDITGYRITT TPTNGQQGNS LEEVVHADQS SCTFDNLSPG LEYNVSVYTV 
      1260       1270       1280       1290       1300
KDDKESVPIS DTIIPAVPPP TDLRFTNIGP DTMRVTWAPP PSIDLTNFLV 
      1310       1320       1330       1340       1350
RYSPVKNEED VAELSISPSD NAVVLTNLLP GTEYVVSVSS VYEQHESTPL 
      1360       1370       1380       1390       1400
RGRQKTGLDS PTGIDFSDIT ANSFTVHWIA PRATITGYRI RHHPEHFSGR 
      1410       1420       1430       1440       1450
PREDRVPHSR NSITLTNLTP GTEYVVSIVA LNGREESPLL IGQQSTVSDV 
      1460       1470       1480       1490       1500
PRDLEVVAAT PTSLLISWDA PAVTVRYYRI TYGETGGNSP VQEFTVPGSK 
      1510       1520       1530       1540       1550
STATISGLKP GVDYTITVYA VTGRGDSPAS SKPISINYRT EIDKPSQMQV 
      1560       1570       1580       1590       1600
TDVQDNSISV KWLPSSSPVT GYRVTTTPKN GPGPTKTKTA GPDQTEMTIE 
      1610       1620       1630       1640       1650
GLQPTVEYVV SVYAQNPSGE SQPLVQTAVT TIPAPTDLKF TQVTPTSLSA 
      1660       1670       1680       1690       1700
QWTPPNVQLT GYRVRVTPKE KTGPMKEINL APDSSSVVVS GLMVATKYEV 
      1710       1720       1730       1740       1750
SVYALKDTLT SRPAQGVVTT LENVSPPRRA RVTDATETTI TISWRTKTET 
      1760       1770       1780       1790       1800
ITGFQVDAVP ANGQTPIQRT IKPDVRSYTI TGLQPGTDYK IYLYTLNDNA 
      1810       1820       1830       1840       1850
RSSPVVIDAS TAIDAPSNLR FLATTPNSLL VSWQPPRARI TGYIIKYEKP 
      1860       1870       1880       1890       1900
GSPPREVVPR PRPGVTEATI TGLEPGTEYT IYVIALKNNQ KSEPLIGRKK 
      1910       1920       1930       1940       1950
TVQKTPFVTH PGYDTGNGIQ LPGTSGQQPS VGQQMIFEEH GFRRTTPPTT 
      1960       1970       1980       1990       2000
ATPIRHRPRP YPPNVGQEAL SQTTISWAPF QDTSEYIISC HPVGTDEEPL 
      2010       2020       2030       2040       2050
QFRVPGTSTS ATLTGLTRGA TYNIIVEALK DQQRHKVREE VVTVGNSVNE 
      2060       2070       2080       2090       2100
GLNQPTDDSC FDPYTVSHYA VGDEWERMSE SGFKLLCQCL GFGSGHFRCD 
      2110       2120       2130       2140       2150
SSRWCHDNGV NYKIGEKWDR QGENGQMMSC TCLGNGKGEF KCDPHEATCY 
      2160       2170       2180       2190       2200
DDGKTYHVGE QWQKEYLGAI CSCTCFGGQR GWRCDNCRRP GGEPSPEGTT 
      2210       2220       2230       2240
GQSYNQYSQR YHQRTNTNVN CPIECFMPLD VQADREDSRE
Length:2,240
Mass (Da):246,698
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC54406F703599CA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC143754 mRNA Translation: AAI43755.1

NCBI Reference Sequences

More...RefSeqi		NP_001293058.1, NM_001306129.1
NP_001293059.1, NM_001306130.1
NP_001293061.1, NM_001306132.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2335

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC143754 mRNA Translation: AAI43755.1
RefSeqiNP_001293058.1, NM_001306129.1
NP_001293059.1, NM_001306130.1
NP_001293061.1, NM_001306132.1

3D structure databases

SMRiB7ZLE5
ModBaseiSearch...

Proteomic databases

PeptideAtlasiB7ZLE5

Genome annotation databases

GeneIDi2335

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2335

Phylogenomic databases

OrthoDBi6580at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2335, 5 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FN1, human
EvolutionaryTraceiB7ZLE5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2335

Family and domain databases

CDDicd00061, FN1, 12 hits
cd00062, FN2, 2 hits
cd00063, FN3, 15 hits
Gene3Di2.10.10.10, 2 hits
2.60.40.10, 15 hits
InterProiView protein in InterPro
IPR000083, Fibronectin_type1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013783, Ig-like_fold
IPR013806, Kringle-like
PfamiView protein in Pfam
PF00039, fn1, 12 hits
PF00040, fn2, 2 hits
PF00041, fn3, 15 hits
SMARTiView protein in SMART
SM00058, FN1, 12 hits
SM00059, FN2, 2 hits
SM00060, FN3, 15 hits
SUPFAMiSSF49265, SSF49265, 9 hits
SSF57440, SSF57440, 2 hits
PROSITEiView protein in PROSITE
PS01253, FN1_1, 6 hits
PS51091, FN1_2, 12 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 2 hits
PS50853, FN3, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7ZLE5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7ZLE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 7, 2020
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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