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Entry version 98 (11 Dec 2019)
Sequence version 1 (03 Mar 2009)
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Protein

Meprin A subunit

Gene

MEP1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi86Zinc; catalyticUniRule annotation1
Metal bindingi183Zinc; via tele nitrogen; catalyticUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei184UniRule annotation1
Metal bindingi187Zinc; via tele nitrogen; catalyticUniRule annotation1
Metal bindingi193Zinc; via tele nitrogen; catalyticUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Meprin A subunitUniRule annotation (EC:3.4.24.-UniRule annotation)
Alternative name(s):
Endopeptidase-2UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEP1AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112818.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7015 MEP1A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 49HelicalSequence analysisAdd BLAST19
Transmembranei746 – 768HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000112818

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112818 Expressed in 52 organ(s), highest expression level in jejunal mucosa

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini295 – 461MAMInterPro annotationAdd BLAST167
Domaini459 – 621MATHInterPro annotationAdd BLAST163
Domaini698 – 738EGF-likeInterPro annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni670 – 691DisorderedSequence analysisAdd BLAST22

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3714 Eukaryota
ENOG410ZPX7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164139

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043106

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEMFRLR

Database of Orthologous Groups

More...
OrthoDBi
241999at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06263 MAM, 1 hit
cd04282 ZnMc_meprin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.210.10, 1 hit
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000998 MAM_dom
IPR002083 MATH/TRAF_dom
IPR008294 Meprin
IPR034301 Meprin_alpha
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR008974 TRAF-like
IPR034038 ZnMP_meprin

The PANTHER Classification System

More...
PANTHERi
PTHR10127:SF824 PTHR10127:SF824, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01400 Astacin, 1 hit
PF00008 EGF, 1 hit
PF00629 MAM, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001196 Meprin, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00480 ASTACIN
PR00020 MAMDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00137 MAM, 1 hit
SM00061 MATH, 1 hit
SM00235 ZnMc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49599 SSF49599, 1 hit
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50026 EGF_3, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit
PS50144 MATH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B7ZL91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWIRSTCIL FFTLLFAHIA AVPVSRVLLF GYLEILILVY IIHFLYIYFF
60 70 80 90 100
QIKYLPEENV HDADFGEQKD ISEINLAAGL DLFQGDILLQ KSRNGLRDPN
110 120 130 140 150
TRWTFPIPYI LADNLGLNAK GAILYAFEMF RLKSCVDFKP YEGESSYIIF
160 170 180 190 200
QQFDGCWSEV GDQHVGQNIS IGQGCAYKAI IEHEILHALG FYHEQSRTDR
210 220 230 240 250
DDYVNIWWDQ ILSGYQHNFD TYDDSLITDL NTPYDYESLM HYQPFSFNKN
260 270 280 290 300
ASVPTITAKI PEFNSIIGQR LDFSAIDLER LNRMYNCTTT HTLLDHCTFE
310 320 330 340 350
KANICGMIQG TRDDTDWAHQ DSAQAGEVDH TLLGQCTGAG YFMQFSTSSG
360 370 380 390 400
SAEEAALLES RILYPKRKQQ CLQFFYKMTG SPSDRLVVWV RRDDSTGNVR
410 420 430 440 450
KLVKVQTFQG DDDHNWKIAH VVLKEEQKFR YLFQGTKGDP QNSTGGIYLD
460 470 480 490 500
DITLTETPCP TGVWTVRNFS QVLENTSKGD KLQSPRFYNS EGYGFGVTLY
510 520 530 540 550
PNSRESSGYL RLAFHVCSGE NDAILEWPVE NRQVIITILD QEPDVRNRMS
560 570 580 590 600
SSMVFTTSKS HTSPAINDTV IWDRPSRVGT YHTDCNCFRS IDLGWSGFIS
610 620 630 640 650
HQMLKRRSFL KNDDLIIFVD FEDITHLSQT EVPTKGKRLS PQGLILQGQE
660 670 680 690 700
QQVSEEGSGK AMLEEALPVS LSQGQPSRQK RSVENTGPLE DHNWPQYFRD
710 720 730 740 750
PCDPNPCQND GICVNVKGMA SCRCISGHAF FYTGERCQAV QVHGSVLGMV
760 770
IGGTAGVIFL TFSIIAILSQ RPRK
Length:774
Mass (Da):87,897
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BF8DE8342E89C99
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q16819MEP1A_HUMAN
Meprin A subunit alpha
MEP1A
746Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL161618 Genomic DNA No translation available.
BC143651 mRNA Translation: AAI43652.1

NCBI Reference Sequences

More...
RefSeqi
XP_011512930.1, XM_011514628.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000611727; ENSP00000480465; ENSG00000112818

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4224

UCSC genome browser

More...
UCSCi
uc011dwh.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161618 Genomic DNA No translation available.
BC143651 mRNA Translation: AAI43652.1
RefSeqiXP_011512930.1, XM_011514628.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENST00000611727; ENSP00000480465; ENSG00000112818
GeneIDi4224
UCSCiuc011dwh.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4224
EuPathDBiHostDB:ENSG00000112818.9
HGNCiHGNC:7015 MEP1A
OpenTargetsiENSG00000112818

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00940000164139
HOGENOMiHOG000043106
OMAiFEMFRLR
OrthoDBi241999at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4224

Gene expression databases

BgeeiENSG00000112818 Expressed in 52 organ(s), highest expression level in jejunal mucosa

Family and domain databases

CDDicd06263 MAM, 1 hit
cd04282 ZnMc_meprin, 1 hit
Gene3Di2.60.210.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000998 MAM_dom
IPR002083 MATH/TRAF_dom
IPR008294 Meprin
IPR034301 Meprin_alpha
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR008974 TRAF-like
IPR034038 ZnMP_meprin
PANTHERiPTHR10127:SF824 PTHR10127:SF824, 1 hit
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF00008 EGF, 1 hit
PF00629 MAM, 1 hit
PIRSFiPIRSF001196 Meprin, 2 hits
PRINTSiPR00480 ASTACIN
PR00020 MAMDOMAIN
SMARTiView protein in SMART
SM00137 MAM, 1 hit
SM00061 MATH, 1 hit
SM00235 ZnMc, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit
PS50144 MATH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7ZL91_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7ZL91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 11, 2019
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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