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UniProtKB - B7ZKV8 (B7ZKV8_HUMAN)
Protein
Sodium/potassium-transporting ATPase subunit beta
Gene
ATP1B4
Organism
Homo sapiens (Human)
Status
Functioni
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane.
UniRule annotationGO - Biological processi
- potassium ion transport Source: InterPro
- sodium ion transport Source: InterPro
Keywordsi
Biological process | Ion transportUniRule annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit betaUniRule annotation |
Gene namesi | Name:ATP1B4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Membrane UniRule annotation
Plasma Membrane
- sodium:potassium-exchanging ATPase complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 108 – 135 | HelicalUniRule annotationAdd BLAST | 28 |
Keywords - Cellular componenti
MembraneStructurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 15 – 80 | DisorderedSequence analysisAdd BLAST | 66 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 42 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 52 – 72 | Acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Signal-anchorARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
OMAi | GVQYDTH |
Family and domain databases
Gene3Di | 2.60.40.1660, 1 hit |
InterProi | View protein in InterPro IPR000402, Na/K_ATPase_sub_beta IPR038702, Na/K_ATPase_sub_beta_sf |
PANTHERi | PTHR11523, PTHR11523, 1 hit |
Pfami | View protein in Pfam PF00287, Na_K-ATPase, 1 hit |
TIGRFAMsi | TIGR01107, Na_K_ATPase_bet, 1 hit |
PROSITEi | View protein in PROSITE PS00390, ATPASE_NA_K_BETA_1, 1 hit PS00391, ATPASE_NA_K_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B7ZKV8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRQLRSRRA PSFPYSYRYR LDDPDEANQN YLADEEEEAE EEARVTVVPK
60 70 80 90 100
SEEEEEEEEK EEEEEEEKEE EEGQGQPTGN AWWQKLQIMS EYLWDPERRM
110 120 130 140 150
FLARTGQSWS LILLIYFFFY ASLAAVITLC MYTLFLTISP YIPTFTERVK
160 170 180 190 200
PPGVMIRPFA HSLNFNFNVS EPDTWQHYVI SLNGFLQGYN DSLQEEMNVD
210 220 230 240 250
CPPGQYFIQD GNEDEDKKAC QFKRSFLKNC SGLEDPTFGY STGQPCILLK
260 270 280 290 300
MNRIVGFRPE LGDPVKVSCK VQRGDENDIR SISYYPESAS FDLRFYPYYG
310 320 330 340 350
KLTHVNYTSP LVAMHFTDVV KNQAVPVQCQ LKGKGVINDV INDRFVGRVI
FTLNIET
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC143404 mRNA Translation: AAI43405.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC143404 mRNA Translation: AAI43405.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B7ZKV8 |
Phylogenomic databases
OMAi | GVQYDTH |
Family and domain databases
Gene3Di | 2.60.40.1660, 1 hit |
InterProi | View protein in InterPro IPR000402, Na/K_ATPase_sub_beta IPR038702, Na/K_ATPase_sub_beta_sf |
PANTHERi | PTHR11523, PTHR11523, 1 hit |
Pfami | View protein in Pfam PF00287, Na_K-ATPase, 1 hit |
TIGRFAMsi | TIGR01107, Na_K_ATPase_bet, 1 hit |
PROSITEi | View protein in PROSITE PS00390, ATPASE_NA_K_BETA_1, 1 hit PS00391, ATPASE_NA_K_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B7ZKV8_HUMAN | |
Accessioni | B7ZKV8Primary (citable) accession number: B7ZKV8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | September 29, 2021 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |