UniProtKB - B7ZKQ8 (B7ZKQ8_HUMAN)
Protein
Podocalyxin
Gene
PODXL
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion.UniRule annotation
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- cell migration Source: UniProtKB-UniRule
- negative regulation of cell adhesion Source: UniProtKB-UniRule
- regulation of cell-cell adhesion Source: InterPro
Keywordsi
Biological process | Cell adhesionUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: PodocalyxinUniRule annotationAlternative name(s): Podocalyxin-like protein 1UniRule annotation |
Gene namesi | Name:PODXLImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma membrane
- Apical cell membrane UniRule annotation
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
Other locations
- cell projection Source: UniProtKB-KW
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 460 – 483 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membraneUniRule annotation, Cell projectionUniRule annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5002866932 | 22 – 560 | PodocalyxinSequence analysisAdd BLAST | 539 |
Proteomic databases
MaxQBi | B7ZKQ8 |
PRIDEi | B7ZKQ8 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 19 – 52 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 85 – 212 | DisorderedSequence analysisAdd BLAST | 128 | |
Regioni | 272 – 340 | DisorderedSequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 32 – 52 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 85 – 186 | PolarSequence analysisAdd BLAST | 102 | |
Compositional biasi | 193 – 212 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 272 – 339 | PolarSequence analysisAdd BLAST | 68 |
Sequence similaritiesi
Belongs to the podocalyxin family.UniRule annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG410IFKB Eukaryota ENOG410YCG4 LUCA |
HOGENOMi | HOG000115601 |
Family and domain databases
InterProi | View protein in InterPro IPR013836 CD34/Podocalyxin IPR017403 PODXL |
PANTHERi | PTHR12067 PTHR12067, 1 hit |
Pfami | View protein in Pfam PF06365 CD34_antigen, 1 hit |
PIRSFi | PIRSF038143 Podocalyxin-like_p1, 2 hits |
i Sequence
Sequence statusi: Complete.
B7ZKQ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRCALALSAL LLLLSTPPLL PSSPSPSPSP SPSQNATQTT TDSSNKTAPT
60 70 80 90 100
PASSVTIMAT DTAQQSTVPT SKANEILASV KATTLGVSSD SPGTTTLAQQ
110 120 130 140 150
VSGPVNTTVA RGGSSGNPTT TIESPKSTKS ADTTTVATST ATAKPNTTSS
160 170 180 190 200
QNGAEDTTNS GGKSSHSVTT DLTSTKAEHL TTPHPTSPLS PRQPTLTHPV
210 220 230 240 250
ATPTSSGHDH LMKISSSSST VAIPGYTFTS PGMTTTLLET VFHHVSQAGL
260 270 280 290 300
ELLTSGDLPT LASQSAGITA SSVISQRTQQ TSSQMPASST APSSQETVQP
310 320 330 340 350
TSPATALRTP TLPETMSSSP TAASTTHRYP KTPSPTVAHE SNWAKCEDLE
360 370 380 390 400
TQTQSEKQLV LNLTGNTLCA GGASDEKLIS LICRAVKATF NPAQDKCGIR
410 420 430 440 450
LASVPGSQTV VVKEITIHTK LPAKDVYERL KDKWDELKEA GVSDMKLGDQ
460 470 480 490 500
GPPEEAEDRF SMPLIITIVC MASFLLLVAA LYGCCHQRLS QRKDQQRLTE
510 520 530 540 550
ELQTVENGYH DNPTLEVMET SSEMQEKKVV SLNGELGDSW IVPLDNLTKD
560
DLDEEEDTHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC143318 mRNA Translation: AAI43319.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC143318 mRNA Translation: AAI43319.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B7ZKQ8 |
PRIDEi | B7ZKQ8 |
Phylogenomic databases
eggNOGi | ENOG410IFKB Eukaryota ENOG410YCG4 LUCA |
HOGENOMi | HOG000115601 |
Miscellaneous databases
ChiTaRSi | PODXL human |
Family and domain databases
InterProi | View protein in InterPro IPR013836 CD34/Podocalyxin IPR017403 PODXL |
PANTHERi | PTHR12067 PTHR12067, 1 hit |
Pfami | View protein in Pfam PF06365 CD34_antigen, 1 hit |
PIRSFi | PIRSF038143 Podocalyxin-like_p1, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7ZKQ8_HUMAN | |
Accessioni | B7ZKQ8Primary (citable) accession number: B7ZKQ8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | July 31, 2019 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |