UniProtKB - B7ZFE0 (B7ZFE0_HUMAN)
Protein
Submitted name:
Solute carrier family 4, anion exchanger, number 1
Gene
AE1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- anion:anion antiporter activity Source: UniProtKB-KW
- inorganic anion exchanger activity Source: InterPro
Keywordsi
Biological process | Anion exchangeARBA annotation, Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Solute carrier family 4, anion exchanger, number 1Imported |
Gene namesi | Name:AE1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 51 – 74 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 95 – 117 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 137 – 162 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 169 – 191 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 211 – 230 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 250 – 270 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 203 | HCO3_cotranspInterPro annotationAdd BLAST | 186 | |
Domaini | 211 – 287 | HCO3_cotranspInterPro annotationAdd BLAST | 77 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationFamily and domain databases
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR018241, Anion_exchange_CS IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk |
PANTHERi | PTHR11453, PTHR11453, 1 hit |
Pfami | View protein in Pfam PF00955, HCO3_cotransp, 2 hits |
PRINTSi | PR00165, ANIONEXCHNGR PR01231, HCO3TRNSPORT |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
B7ZFE0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
DSSFYKGLDL NGGPDDPLQQ TGQLFGGLVR DIRRRYPYYL SDITDAFSPQ
60 70 80 90 100
VLAAVIFIYF AALSPAITFG GLLGEKTRNQ MGVSELLIST AVQGILFALL
110 120 130 140 150
GAQPLLVVGF SGPLLVFEEA FFSFCETNGL EYIVGRVWIG FWLILLVVLV
160 170 180 190 200
VAFEGSFLVR FISRYTQKIF SFLISLIFIY ETFSKLIKIF QDHPLQKTYN
210 220 230 240 250
YNVLMVPKPQ GPLPNTALLS LVLMAGTFFF AMMLRKFKNS SYFPGKLRRV
260 270 280
IGDFGVPISI LIMVLVDFFI QDTYTQKLSV PDGFKVSN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 288 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM919470 mRNA Translation: CAP46016.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM919470 mRNA Translation: CAP46016.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B7ZFE0 |
Miscellaneous databases
ChiTaRSi | SLC4A1, human |
Family and domain databases
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR018241, Anion_exchange_CS IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk |
PANTHERi | PTHR11453, PTHR11453, 1 hit |
Pfami | View protein in Pfam PF00955, HCO3_cotransp, 2 hits |
PRINTSi | PR00165, ANIONEXCHNGR PR01231, HCO3TRNSPORT |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7ZFE0_HUMAN | |
Accessioni | B7ZFE0Primary (citable) accession number: B7ZFE0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | December 2, 2020 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |