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Entry version 94 (26 Feb 2020)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Ubiquitin-specific peptidase 19

Gene

usp19

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-5689880 Ub-specific processing proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ubiquitin-specific peptidase 19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:usp19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 23

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-3055 usp19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1451 – 1474HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B7ZDA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000004132 Expressed in mature ovarian follicle and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B7ZDA8 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000116060

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 143CSInterPro annotationAdd BLAST92
Domaini421 – 523CSInterPro annotationAdd BLAST103
Domaini638 – 1355USPInterPro annotationAdd BLAST718
Domaini925 – 967MYND-typeInterPro annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47
Regioni153 – 419DisorderedSequence analysisAdd BLAST267
Regioni523 – 621DisorderedSequence analysisAdd BLAST99
Regioni1009 – 1080DisorderedSequence analysisAdd BLAST72
Regioni1414 – 1441DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 47PolyampholyteSequence analysisAdd BLAST34
Compositional biasi153 – 178PolarSequence analysisAdd BLAST26
Compositional biasi205 – 238PolyampholyteSequence analysisAdd BLAST34
Compositional biasi253 – 291PolarSequence analysisAdd BLAST39
Compositional biasi309 – 339PolarSequence analysisAdd BLAST31
Compositional biasi341 – 359PolyampholyteSequence analysisAdd BLAST19
Compositional biasi376 – 407PolyampholyteSequence analysisAdd BLAST32
Compositional biasi541 – 555PolarSequence analysisAdd BLAST15
Compositional biasi560 – 576PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1009 – 1035PolarSequence analysisAdd BLAST27
Compositional biasi1054 – 1080PolarSequence analysisAdd BLAST27

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1870 Eukaryota
COG5560 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159085

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B7ZDA8

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECVEDPS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B7ZDA8

TreeFam database of animal gene trees

More...
TreeFami
TF106276

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.790, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR002893 Znf_MYND

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04969 CS, 1 hit
PF00443 UCH, 1 hit
PF01753 zf-MYND, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49764 SSF49764, 2 hits
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51203 CS, 2 hits
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B7ZDA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSSTGSSE SGRRRGQRGP DDTVSTSKKK QKDRANQESK EAKRVATSTE
60 70 80 90 100
TKKDLFLDWK QNAYEVIVRL NCGGAGELRV EDIEYDFSNS ACHIRLPDGR
110 120 130 140 150
EWSCHLHEEI EASCSKLNYK EKSNVLQLVM HKKIPLNTWP AYAKKSEPVN
160 170 180 190 200
ILQKNGSNNY QSSTGRSEKS SEAIEKTPPV SSAEQKRGKP DRGLKRGMKG
210 220 230 240 250
KQVHVTKSTG EKTPEIKSSD KADSINEPSA KRTTRPSKNT KEPPLAPCLG
260 270 280 290 300
NESKSKATVN GKTHTSEVNS GASSSSNAKD NRAQMQGKPQ GCQALQKEKG
310 320 330 340 350
IDRKPKSNAQ VGSGESKSVS VCEPQVPQKD HSTPVKTCTD KIASDEPENR
360 370 380 390 400
KEETKPQAEG HIPKMLPSHD LGSGEPASTD SKREESPQKS HTEEKRDKSK
410 420 430 440 450
EEPQGASQEE DTEGPEPMVD LKFVKNDSYE KGTDLMVVNV YMKEICRQTS
460 470 480 490 500
RVLFREQDFT LIFQTSDPNF LRLHSDCGPN TVFKWQVKLR NLIQPDQSNY
510 520 530 540 550
AFTPSRIDIT LKKRHSQRWG GLEAPATQGA VGGAKVAVAS SPSTLEKSQP
560 570 580 590 600
GSSQHALPAK EEPRVGEEKP KPPRAPEDSG LDAVSPRSVS EHVSLKQEPA
610 620 630 640 650
VATPKPTCMV QPMTHTPPVG NERSEEVEEK KVCHPGFTGL VNLGNTCFMN
660 670 680 690 700
SVIQSLSNTR ELRDYFHDRG FESEINCNNP LGTGGRLAIG FAVLLRALWK
710 720 730 740 750
GTHHAFQPSK LKAIVASKAS QFTGYAQHDA QEFMAFLLDG LHEDLNRIQN
760 770 780 790 800
KPYTETVDSD GRQDEVVAEE AWQRHKMRND SFIVDLFQGQ YKSKLVSITF
810 820 830 840 850
DPFLYLPVPL PQKQKVLTVF YFAKEPHKKP VKFLVSVSKE SSSTAEVLES
860 870 880 890 900
ISRSVRIKPE NLRLTEVVKG RFHRIFSPSQ SLDTVSSSDL LFCFEMLSKD
910 920 930 940 950
LIKERVVLLK VQQRPQIPSI PITKCAGCLK PPASDDEKLK RCTRCYRVGY
960 970 980 990 1000
CNQTCQKNHW PSHKTMCRSN VENIGQPFLI SVPESRLSYT RLTQLLEGYS
1010 1020 1030 1040 1050
RYSVNVFQPP FQSGRTSPES SLSRVDLTSM ASSVPECQEK DLPSAGDPEN
1060 1070 1080 1090 1100
PAEQDESVTA SQTESAADGG DTLSTHTTDS GCCELASSSH DSLLEKETSC
1110 1120 1130 1140 1150
EKAVKPEAVV TGYQQPSESA SGGASQFYIT ILDSSQKEDK KLEEKGDAVL
1160 1170 1180 1190 1200
ELPDECTLEL VWKNNERQKE YVLVRSKDLE FDEDPGSATE TSRAGHFTLE
1210 1220 1230 1240 1250
QCLNLFTKPE VLAPEEAWYC PKCQQHREAS KQLLLWRLPN VLIIQLKRFS
1260 1270 1280 1290 1300
FRSFIWRDKI NDMVDFPVRN LDLSKFCIGH KGDIQQPPIY DLYAVINHYG
1310 1320 1330 1340 1350
GMIGGHYTAY ARLPSDKNSQ LSDVGWRLFD DSTVTTVEES QVVTRYAYVL
1360 1370 1380 1390 1400
FYRRRNSPVE RPSHLLGPLG AESSAATGGA ASQASLIWQE LEEDEEGQRE
1410 1420 1430 1440 1450
ASFRSLFRPG LRGRRARMRP EQEEEEEGRG GLSHRRRDDN SDYSDGERMR
1460 1470
YFILGTVAAI LALLFNLIYP LLYWSNWV
Length:1,478
Mass (Da):165,223
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1B9A84B601F666F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1RCS0F1RCS0_DANRE
Ubiquitin-specific peptidase 19
usp19
1,436Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZDA9B7ZDA9_DANRE
Ubiquitin-specific peptidase 19
usp19
227Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL953864 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000147778; ENSDARP00000116060; ENSDARG00000004132
ENSDART00000189562; ENSDARP00000157435; ENSDARG00000004132

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL953864 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000116060

Proteomic databases

PaxDbiB7ZDA8

Genome annotation databases

EnsembliENSDART00000147778; ENSDARP00000116060; ENSDARG00000004132
ENSDART00000189562; ENSDARP00000157435; ENSDARG00000004132

Organism-specific databases

ZFINiZDB-GENE-030131-3055 usp19

Phylogenomic databases

eggNOGiKOG1870 Eukaryota
COG5560 LUCA
GeneTreeiENSGT00940000159085
InParanoidiB7ZDA8
OMAiECVEDPS
PhylomeDBiB7ZDA8
TreeFamiTF106276

Enzyme and pathway databases

ReactomeiR-DRE-5689880 Ub-specific processing proteases

Gene expression databases

BgeeiENSDARG00000004132 Expressed in mature ovarian follicle and 26 other tissues
ExpressionAtlasiB7ZDA8 baseline

Family and domain databases

Gene3Di2.60.40.790, 2 hits
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF00443 UCH, 1 hit
PF01753 zf-MYND, 1 hit
SUPFAMiSSF49764 SSF49764, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 2 hits
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7ZDA8_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7ZDA8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 26, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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