Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adhesion G-protein coupled receptor G4

Gene

Adgrg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Orphan receptor.

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.014

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G4
Alternative name(s):
G-protein coupled receptor 112
Gene namesi
Name:Adgrg4
Synonyms:Gpr112
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2685213 Adgrg4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 2691ExtracellularCuratedAdd BLAST2666
Transmembranei2692 – 2712Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2713 – 2728CytoplasmicCuratedAdd BLAST16
Transmembranei2729 – 2749Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2750 – 2755ExtracellularCurated6
Transmembranei2756 – 2776Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2777 – 2798CytoplasmicCuratedAdd BLAST22
Transmembranei2799 – 2819Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2820 – 2842ExtracellularCuratedAdd BLAST23
Transmembranei2843 – 2863Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2864 – 2892CytoplasmicCuratedAdd BLAST29
Transmembranei2893 – 2913Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2914ExtracellularCurated1
Transmembranei2915 – 2935Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2936 – 3073CytoplasmicCuratedAdd BLAST138

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000038547726 – 3073Adhesion G-protein coupled receptor G4Add BLAST3048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 123PROSITE-ProRule annotation
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi662N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1495N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiB7ZCC9
PeptideAtlasiB7ZCC9
PRIDEiB7ZCC9

PTM databases

iPTMnetiB7ZCC9
PhosphoSitePlusiB7ZCC9

Expressioni

Gene expression databases

BgeeiENSMUSG00000053852 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiB7ZCC9 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116634

Structurei

3D structure databases

ProteinModelPortaliB7ZCC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 228Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST200
Domaini2632 – 2683GPSPROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1567 – 1570Poly-Ser4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
HOGENOMiHOG000230882
InParanoidiB7ZCC9
OrthoDBiEOG091G00P5

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B7ZCC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKHILHQRL CGLILVSSFI FLTDSLSLKG KRLDFYGEGK AYVSLTYTMP
60 70 80 90 100
ELSRLTACID LISMTNSSHY WMAFIYITNN TLLGREDVDL GLAGDHQQLI
110 120 130 140 150
LYSFGKTFYV SYHLIPFHWH TLCLVWDGVK GRLELFRNKE RILAIMDQPH
160 170 180 190 200
RLSPNGTLVL GHFPRNGEGQ IKTVIPRFTS SLYYFQLWDR ILENEEFMTC
210 220 230 240 250
FYGNVVSWED DVWLIHKISP TVDRRLRCFV SENMTIQETS TNVSQQIDLT
260 270 280 290 300
TSSQTTGLNP HKTSHSSTLL PEGMADSTIN STAISYANTV PSPLATVSAA
310 320 330 340 350
KDLKTSTTET ATFLTDTLFT STATPLPTQT VTEHSYLGKT RTSKRVEAMA
360 370 380 390 400
TEIFHSATAT DLIDTSVFTK NYTVSETSTT KSKSAVGKTT LFLNESTSIA
410 420 430 440 450
PTPCPKHKST DVAILHTSKS GQEFLVSSAA RTVSWSTLEE TSPITTDVGI
460 470 480 490 500
VSTFPPESLL TSTASPVSST FPEIQLASTL STTDSEMAST VHSVLPMQTI
510 520 530 540 550
PTPRTVKPES GSTNFQDVFS PSMEDALSVS MPKETTFMAF SSITSSPITR
560 570 580 590 600
TQDEQIAIDA ESTHLTIIPG TKFVPTLAEA SLFPTIEGQA YTQDTPTTDE
610 620 630 640 650
PMLTLTSTKS PSTYNASESV LTSITIKSDY QFFTNETTWT SKSGQNLLTS
660 670 680 690 700
MNTTTIPTFT SNKTLTLPFQ GNATNRDHSS MTTNVSPIEA STESKVTTSS
710 720 730 740 750
DATTASYTTA LFKPTSQWLS HFTSVSGITS IASQPESKLT TLLLKSNSMP
760 770 780 790 800
TVATNEFPSI PSEPVAPSVN TSTLTDIKPN FSTEKSISET IQIETNGVSS
810 820 830 840 850
FGDTLAPLPM SATTQRVYTT VTKETTSRHP KVKSTISTVA EASPFSTMLE
860 870 880 890 900
VTDESEQMVT ASVTISPFTD IEKLTTALSK ETATAEVGVS WLSTKLKESM
910 920 930 940 950
PESSHNGTTE SFNSTHTYTV DWTSEKSKGN SASSPNSAST QALPELPSSS
960 970 980 990 1000
TMKTMGVTFS TNSSQRTAAS LSAGILSPQT ASTHALVTPQ LLTHTFSLPV
1010 1020 1030 1040 1050
NISAVTSPKT TMVFFDETKV TLSQPSTLAR DFTTSMPSVG STLPTVTMTT
1060 1070 1080 1090 1100
ELVPPVSPTA STISDSMFTH RDLLHTTSEV TTISSTTAHM AISSLRETLV
1110 1120 1130 1140 1150
SSLRPPTPVI TKAISTIPSI SSDSVSPSIH TLVCSRPSPN NVTIVSSTYV
1160 1170 1180 1190 1200
SSTTSTSVAT PSESHFSFPY AFSSGGDVTM ASGPTGTSAG GEAMPPNTFV
1210 1220 1230 1240 1250
NKFITSVDHE STTYFVNTPV STQSVFATSM VSSDKEQTNI SMEKTLRTTG
1260 1270 1280 1290 1300
VAEISPSKNS FILDSQSTFP WEMTDTELSE TTEISSHQTH LPSEILPGYS
1310 1320 1330 1340 1350
DSGNLTTFST SGSTQSAQTL SSSTIIGVRV SEGSTSLEKT ALPSQVQTVT
1360 1370 1380 1390 1400
KSLTHDKERT SALSEYPPRT VEKIMSSSPV THQATGHLAT SIVDASRTTR
1410 1420 1430 1440 1450
ISHPVLINTT LSYLLSLKTK PEATQIASST SGSTENFPNS FSPFTTGLLS
1460 1470 1480 1490 1500
TNFTMITPNG STTVLSIPNE PTNLPKKTSM EASTPISQMD LLALNVTAFT
1510 1520 1530 1540 1550
SKKVSDTHTM LMTKSSRTIH IGTLKSVSIG TFGLKSEKSE MPVNNSDFST
1560 1570 1580 1590 1600
TVLYSDTSTR LGEFFTSSSS LPPKATKTTQ ASTLNTTPVA HAGPTSQRTV
1610 1620 1630 1640 1650
FSSTFSNSSV VEVPLNYTTA HFSSPTQRGF LSMKTIPTTS MAGISTSVIG
1660 1670 1680 1690 1700
ATSSSLSSSK NTEPISSIPK TMFSLLLSTT QQPSQENGAP TLDILPGITV
1710 1720 1730 1740 1750
SSGGATDLIN ANSRATIPAN ELSTTPSDNF YTFLNTQDSP TLTNSKVTPR
1760 1770 1780 1790 1800
PTESVKSTPT HLSFDTRKMN ILTELTKSGP CVTTPVLYPL WTQTSTAPPL
1810 1820 1830 1840 1850
TSHLYSPHST KAKFPLASQM AEYPAWATGI TPSITQALLT TSRNTQRVED
1860 1870 1880 1890 1900
SPFPVFTTKV MTPNRMEVET LHSPSGTLAT STTSQIGLVS RDVTVMPLIS
1910 1920 1930 1940 1950
TSESLPSLGI SESTSLSISS TFPPTTLAAI LPTFEKTAMP VTPGITLSSN
1960 1970 1980 1990 2000
PSVNSRATSP TWSSSSLPSD SRASIFTPSR LLTSSSGEMS ESTFPASDII
2010 2020 2030 2040 2050
ATYSNFTVAP LSDGSATIAT QATSTTTLDI ITANSLTSPP IPSKDKDGSL
2060 2070 2080 2090 2100
HTSTFLESSL RTTGADSSTD MSERMSFGRT SISPSLTRHD LSIGSLTVSS
2110 2120 2130 2140 2150
PTNTSPWSKV PVTSESHTLF PSKSTLDSVM STATTTSTAI GTSFPLMSTE
2160 2170 2180 2190 2200
MAHPSTATGF SLVSSSFETT WMDSIFSSLF TQPSTSPTAK ESTVSFYNIK
2210 2220 2230 2240 2250
MSFSVFDEEP RVLVTTVIHD LTKDWLNFMF QNSEFSLANL AIQIKSRKTS
2260 2270 2280 2290 2300
KEETAMYRYI LEQKKGQGMD AIFHVPYSCA CWVIIKAKSS LESVELISSI
2310 2320 2330 2340 2350
RTKIHGNLTH GNFTQDQLTL LVKSDHVVVE KLEPGKCEAD ETPSKYKGTY
2360 2370 2380 2390 2400
KWPLTDPTET AQERCIKNEN RNATRICSIS IQTGKCQWEK PRLKQCKLLQ
2410 2420 2430 2440 2450
GLPDKIVDLA NITISDENAD DVAEHILNLV NESPPLDEEE TKIIVSKVAD
2460 2470 2480 2490 2500
ISNCDEISIN LTQIILQILN TVTEKQSDSA SNLPPVSNEI LRIIERVGHK
2510 2520 2530 2540 2550
MEFAGRTANL TVAKLALAVL RVDHKFEGMA FSIQSSEEVI APQIFLGDIP
2560 2570 2580 2590 2600
LRKALASIYL PKSLREKVPL DGLQTILFNF FGQTSLFKAK TITSELMTYV
2610 2620 2630 2640 2650
VSASISNTSI QNLADPVIII LKHIQGDWNY DQVYCAFWDF DTNNGLGGWN
2660 2670 2680 2690 2700
PSGCKLKESN INYTICQCNH LTHFGVLMDL SRSTVDAVNE RILVIITYTG
2710 2720 2730 2740 2750
CGISSIFLGI AMVTYIAFHK LRKDYPSKIL INLCTALLML NLAFLVNSWL
2760 2770 2780 2790 2800
TSFQKVGLCI TAAVALHYFL LVSLTWMGLE AVHMYFALVK VFNTYIPNYI
2810 2820 2830 2840 2850
LKFCLAGWGI PAITVAIILS VRKDLYGTLS PTTPFCWIKD DHIFYISVVA
2860 2870 2880 2890 2900
YFCLIFLMNL SMFCTVLVQL TSVKSQSQKT RKKMILNDLK GTISLTFLLG
2910 2920 2930 2940 2950
LTWGFAFFAW GPVRIFFLYL FAICNTLQGF LIFVFYCVMK ESVREQWHMP
2960 2970 2980 2990 3000
LHCRWLRLEN FAGWINVRHK QKRLKKNNES KLLTPSLMST TTFKSIGSVP
3010 3020 3030 3040 3050
SIPSEINFSN GDFDDSPDTF SFLSCKAAPT FIRRALPAEI QTNSTQKQRS
3060 3070
FPINVSRDTH LTPSSGLGEM FNL
Length:3,073
Mass (Da):334,211
Last modified:March 3, 2009 - v1
Checksum:iED17E7ED8D55EBDA
GO
Isoform 2 (identifier: B7ZCC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: D → V
     25-229: Missing.

Note: No experimental confirmation available.
Show »
Length:2,868
Mass (Da):310,201
Checksum:i39CBEC343C4323F9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UNS7Q3UNS7_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg4 Gpr112, mCG_118915
216Annotation score:
B7ZCD1B7ZCD1_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg4
2,736Annotation score:
F6Y0G3F6Y0G3_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg4
205Annotation score:
Q80T58Q80T58_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg4 Gpr112
177Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03817724D → V in isoform 2. Curated1
Alternative sequenceiVSP_03817825 – 229Missing in isoform 2. CuratedAdd BLAST205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672263, AL671998 Genomic DNA Translation: CAX16065.1
AL672263, AL671998 Genomic DNA Translation: CAX16066.1
AL671998, AL672263 Genomic DNA Translation: CAX16092.1
AL671998, AL672263 Genomic DNA Translation: CAX16093.1
UniGeneiMm.35282

Genome annotation databases

EnsembliENSMUST00000153784; ENSMUSP00000116634; ENSMUSG00000053852 [B7ZCC9-1]
ENSMUST00000154818; ENSMUSP00000119486; ENSMUSG00000053852 [B7ZCC9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672263, AL671998 Genomic DNA Translation: CAX16065.1
AL672263, AL671998 Genomic DNA Translation: CAX16066.1
AL671998, AL672263 Genomic DNA Translation: CAX16092.1
AL671998, AL672263 Genomic DNA Translation: CAX16093.1
UniGeneiMm.35282

3D structure databases

ProteinModelPortaliB7ZCC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116634

Protein family/group databases

MEROPSiP02.014
GPCRDBiSearch...

PTM databases

iPTMnetiB7ZCC9
PhosphoSitePlusiB7ZCC9

Proteomic databases

PaxDbiB7ZCC9
PeptideAtlasiB7ZCC9
PRIDEiB7ZCC9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000153784; ENSMUSP00000116634; ENSMUSG00000053852 [B7ZCC9-1]
ENSMUST00000154818; ENSMUSP00000119486; ENSMUSG00000053852 [B7ZCC9-2]

Organism-specific databases

MGIiMGI:2685213 Adgrg4

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
HOGENOMiHOG000230882
InParanoidiB7ZCC9
OrthoDBiEOG091G00P5

Miscellaneous databases

PROiPR:B7ZCC9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053852 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiB7ZCC9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG4_MOUSE
AccessioniPrimary (citable) accession number: B7ZCC9
Secondary accession number(s): B7ZCD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again