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UniProtKB - B7ZCC9 (AGRG4_MOUSE)
Protein
Adhesion G-protein coupled receptor G4
Gene
Adgrg4
Organism
Mus musculus (Mouse)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- cell surface receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Protein family/group databases
MEROPSi | P02.014 |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G-protein coupled receptor G4Alternative name(s): G-protein coupled receptor 112 |
Gene namesi | Name:Adgrg4 Synonyms:Gpr112 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685213, Adgrg4 |
VEuPathDBi | HostDB:ENSMUSG00000053852 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 2691 | ExtracellularCuratedAdd BLAST | 2666 | |
Transmembranei | 2692 – 2712 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2713 – 2728 | CytoplasmicCuratedAdd BLAST | 16 | |
Transmembranei | 2729 – 2749 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2750 – 2755 | ExtracellularCurated | 6 | |
Transmembranei | 2756 – 2776 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2777 – 2798 | CytoplasmicCuratedAdd BLAST | 22 | |
Transmembranei | 2799 – 2819 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2820 – 2842 | ExtracellularCuratedAdd BLAST | 23 | |
Transmembranei | 2843 – 2863 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2864 – 2892 | CytoplasmicCuratedAdd BLAST | 29 | |
Transmembranei | 2893 – 2913 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2914 | ExtracellularCurated | 1 | |
Transmembranei | 2915 – 2935 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2936 – 3073 | CytoplasmicCuratedAdd BLAST | 138 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000385477 | 26 – 3073 | Adhesion G-protein coupled receptor G4Add BLAST | 3048 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 58 ↔ 123 | PROSITE-ProRule annotation | ||
Glycosylationi | 233 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 662 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1141 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1304 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1495 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | B7ZCC9 |
PeptideAtlasi | B7ZCC9 |
PRIDEi | B7ZCC9 |
ProteomicsDBi | 282035 [B7ZCC9-1] 282036 [B7ZCC9-2] |
PTM databases
GlyGeni | B7ZCC9, 5 sites |
iPTMneti | B7ZCC9 |
PhosphoSitePlusi | B7ZCC9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000053852, Expressed in proximal tubule and 34 other tissues |
ExpressionAtlasi | B7ZCC9, baseline and differential |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000094165 |
Miscellaneous databases
RNActi | B7ZCC9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 228 | Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST | 200 | |
Domaini | 2632 – 2683 | GPSPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 253 – 272 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 671 – 697 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 924 – 951 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1565 – 1595 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1741 – 1760 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1945 – 1972 | DisorderedSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000162744 |
HOGENOMi | CLU_000643_0_0_1 |
InParanoidi | B7ZCC9 |
OMAi | NFTTLPF |
PhylomeDBi | B7ZCC9 |
Family and domain databases
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR001759, Pentraxin-related |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00303, GPS, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS51828, PTX_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: B7ZCC9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRKHILHQRL CGLILVSSFI FLTDSLSLKG KRLDFYGEGK AYVSLTYTMP
60 70 80 90 100
ELSRLTACID LISMTNSSHY WMAFIYITNN TLLGREDVDL GLAGDHQQLI
110 120 130 140 150
LYSFGKTFYV SYHLIPFHWH TLCLVWDGVK GRLELFRNKE RILAIMDQPH
160 170 180 190 200
RLSPNGTLVL GHFPRNGEGQ IKTVIPRFTS SLYYFQLWDR ILENEEFMTC
210 220 230 240 250
FYGNVVSWED DVWLIHKISP TVDRRLRCFV SENMTIQETS TNVSQQIDLT
260 270 280 290 300
TSSQTTGLNP HKTSHSSTLL PEGMADSTIN STAISYANTV PSPLATVSAA
310 320 330 340 350
KDLKTSTTET ATFLTDTLFT STATPLPTQT VTEHSYLGKT RTSKRVEAMA
360 370 380 390 400
TEIFHSATAT DLIDTSVFTK NYTVSETSTT KSKSAVGKTT LFLNESTSIA
410 420 430 440 450
PTPCPKHKST DVAILHTSKS GQEFLVSSAA RTVSWSTLEE TSPITTDVGI
460 470 480 490 500
VSTFPPESLL TSTASPVSST FPEIQLASTL STTDSEMAST VHSVLPMQTI
510 520 530 540 550
PTPRTVKPES GSTNFQDVFS PSMEDALSVS MPKETTFMAF SSITSSPITR
560 570 580 590 600
TQDEQIAIDA ESTHLTIIPG TKFVPTLAEA SLFPTIEGQA YTQDTPTTDE
610 620 630 640 650
PMLTLTSTKS PSTYNASESV LTSITIKSDY QFFTNETTWT SKSGQNLLTS
660 670 680 690 700
MNTTTIPTFT SNKTLTLPFQ GNATNRDHSS MTTNVSPIEA STESKVTTSS
710 720 730 740 750
DATTASYTTA LFKPTSQWLS HFTSVSGITS IASQPESKLT TLLLKSNSMP
760 770 780 790 800
TVATNEFPSI PSEPVAPSVN TSTLTDIKPN FSTEKSISET IQIETNGVSS
810 820 830 840 850
FGDTLAPLPM SATTQRVYTT VTKETTSRHP KVKSTISTVA EASPFSTMLE
860 870 880 890 900
VTDESEQMVT ASVTISPFTD IEKLTTALSK ETATAEVGVS WLSTKLKESM
910 920 930 940 950
PESSHNGTTE SFNSTHTYTV DWTSEKSKGN SASSPNSAST QALPELPSSS
960 970 980 990 1000
TMKTMGVTFS TNSSQRTAAS LSAGILSPQT ASTHALVTPQ LLTHTFSLPV
1010 1020 1030 1040 1050
NISAVTSPKT TMVFFDETKV TLSQPSTLAR DFTTSMPSVG STLPTVTMTT
1060 1070 1080 1090 1100
ELVPPVSPTA STISDSMFTH RDLLHTTSEV TTISSTTAHM AISSLRETLV
1110 1120 1130 1140 1150
SSLRPPTPVI TKAISTIPSI SSDSVSPSIH TLVCSRPSPN NVTIVSSTYV
1160 1170 1180 1190 1200
SSTTSTSVAT PSESHFSFPY AFSSGGDVTM ASGPTGTSAG GEAMPPNTFV
1210 1220 1230 1240 1250
NKFITSVDHE STTYFVNTPV STQSVFATSM VSSDKEQTNI SMEKTLRTTG
1260 1270 1280 1290 1300
VAEISPSKNS FILDSQSTFP WEMTDTELSE TTEISSHQTH LPSEILPGYS
1310 1320 1330 1340 1350
DSGNLTTFST SGSTQSAQTL SSSTIIGVRV SEGSTSLEKT ALPSQVQTVT
1360 1370 1380 1390 1400
KSLTHDKERT SALSEYPPRT VEKIMSSSPV THQATGHLAT SIVDASRTTR
1410 1420 1430 1440 1450
ISHPVLINTT LSYLLSLKTK PEATQIASST SGSTENFPNS FSPFTTGLLS
1460 1470 1480 1490 1500
TNFTMITPNG STTVLSIPNE PTNLPKKTSM EASTPISQMD LLALNVTAFT
1510 1520 1530 1540 1550
SKKVSDTHTM LMTKSSRTIH IGTLKSVSIG TFGLKSEKSE MPVNNSDFST
1560 1570 1580 1590 1600
TVLYSDTSTR LGEFFTSSSS LPPKATKTTQ ASTLNTTPVA HAGPTSQRTV
1610 1620 1630 1640 1650
FSSTFSNSSV VEVPLNYTTA HFSSPTQRGF LSMKTIPTTS MAGISTSVIG
1660 1670 1680 1690 1700
ATSSSLSSSK NTEPISSIPK TMFSLLLSTT QQPSQENGAP TLDILPGITV
1710 1720 1730 1740 1750
SSGGATDLIN ANSRATIPAN ELSTTPSDNF YTFLNTQDSP TLTNSKVTPR
1760 1770 1780 1790 1800
PTESVKSTPT HLSFDTRKMN ILTELTKSGP CVTTPVLYPL WTQTSTAPPL
1810 1820 1830 1840 1850
TSHLYSPHST KAKFPLASQM AEYPAWATGI TPSITQALLT TSRNTQRVED
1860 1870 1880 1890 1900
SPFPVFTTKV MTPNRMEVET LHSPSGTLAT STTSQIGLVS RDVTVMPLIS
1910 1920 1930 1940 1950
TSESLPSLGI SESTSLSISS TFPPTTLAAI LPTFEKTAMP VTPGITLSSN
1960 1970 1980 1990 2000
PSVNSRATSP TWSSSSLPSD SRASIFTPSR LLTSSSGEMS ESTFPASDII
2010 2020 2030 2040 2050
ATYSNFTVAP LSDGSATIAT QATSTTTLDI ITANSLTSPP IPSKDKDGSL
2060 2070 2080 2090 2100
HTSTFLESSL RTTGADSSTD MSERMSFGRT SISPSLTRHD LSIGSLTVSS
2110 2120 2130 2140 2150
PTNTSPWSKV PVTSESHTLF PSKSTLDSVM STATTTSTAI GTSFPLMSTE
2160 2170 2180 2190 2200
MAHPSTATGF SLVSSSFETT WMDSIFSSLF TQPSTSPTAK ESTVSFYNIK
2210 2220 2230 2240 2250
MSFSVFDEEP RVLVTTVIHD LTKDWLNFMF QNSEFSLANL AIQIKSRKTS
2260 2270 2280 2290 2300
KEETAMYRYI LEQKKGQGMD AIFHVPYSCA CWVIIKAKSS LESVELISSI
2310 2320 2330 2340 2350
RTKIHGNLTH GNFTQDQLTL LVKSDHVVVE KLEPGKCEAD ETPSKYKGTY
2360 2370 2380 2390 2400
KWPLTDPTET AQERCIKNEN RNATRICSIS IQTGKCQWEK PRLKQCKLLQ
2410 2420 2430 2440 2450
GLPDKIVDLA NITISDENAD DVAEHILNLV NESPPLDEEE TKIIVSKVAD
2460 2470 2480 2490 2500
ISNCDEISIN LTQIILQILN TVTEKQSDSA SNLPPVSNEI LRIIERVGHK
2510 2520 2530 2540 2550
MEFAGRTANL TVAKLALAVL RVDHKFEGMA FSIQSSEEVI APQIFLGDIP
2560 2570 2580 2590 2600
LRKALASIYL PKSLREKVPL DGLQTILFNF FGQTSLFKAK TITSELMTYV
2610 2620 2630 2640 2650
VSASISNTSI QNLADPVIII LKHIQGDWNY DQVYCAFWDF DTNNGLGGWN
2660 2670 2680 2690 2700
PSGCKLKESN INYTICQCNH LTHFGVLMDL SRSTVDAVNE RILVIITYTG
2710 2720 2730 2740 2750
CGISSIFLGI AMVTYIAFHK LRKDYPSKIL INLCTALLML NLAFLVNSWL
2760 2770 2780 2790 2800
TSFQKVGLCI TAAVALHYFL LVSLTWMGLE AVHMYFALVK VFNTYIPNYI
2810 2820 2830 2840 2850
LKFCLAGWGI PAITVAIILS VRKDLYGTLS PTTPFCWIKD DHIFYISVVA
2860 2870 2880 2890 2900
YFCLIFLMNL SMFCTVLVQL TSVKSQSQKT RKKMILNDLK GTISLTFLLG
2910 2920 2930 2940 2950
LTWGFAFFAW GPVRIFFLYL FAICNTLQGF LIFVFYCVMK ESVREQWHMP
2960 2970 2980 2990 3000
LHCRWLRLEN FAGWINVRHK QKRLKKNNES KLLTPSLMST TTFKSIGSVP
3010 3020 3030 3040 3050
SIPSEINFSN GDFDDSPDTF SFLSCKAAPT FIRRALPAEI QTNSTQKQRS
3060 3070
FPINVSRDTH LTPSSGLGEM FNL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZCD1 | B7ZCD1_MOUSE | Adhesion G-protein-coupled receptor... | Adgrg4 | 2,736 | Annotation score: | ||
Q3UNS7 | Q3UNS7_MOUSE | Adhesion G-protein-coupled receptor... | Adgrg4 Gpr112 | 216 | Annotation score: | ||
F6Y0G3 | F6Y0G3_MOUSE | Adhesion G-protein-coupled receptor... | Adgrg4 | 205 | Annotation score: | ||
Q80T58 | Q80T58_MOUSE | Adhesion G-protein-coupled receptor... | Adgrg4 Gpr112 | 177 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038177 | 24 | D → V in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_038178 | 25 – 229 | Missing in isoform 2. CuratedAdd BLAST | 205 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL671998 Genomic DNA No translation available. AL672263 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000153784; ENSMUSP00000116634; ENSMUSG00000053852 [B7ZCC9-1] ENSMUST00000154818; ENSMUSP00000119486; ENSMUSG00000053852 [B7ZCC9-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL671998 Genomic DNA No translation available. AL672263 Genomic DNA No translation available. |
3D structure databases
SMRi | B7ZCC9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000094165 |
Protein family/group databases
MEROPSi | P02.014 |
GPCRDBi | Search... |
PTM databases
GlyGeni | B7ZCC9, 5 sites |
iPTMneti | B7ZCC9 |
PhosphoSitePlusi | B7ZCC9 |
Proteomic databases
PaxDbi | B7ZCC9 |
PeptideAtlasi | B7ZCC9 |
PRIDEi | B7ZCC9 |
ProteomicsDBi | 282035 [B7ZCC9-1] 282036 [B7ZCC9-2] |
Protocols and materials databases
Antibodypediai | 51733, 43 antibodies from 17 providers |
Genome annotation databases
Ensembli | ENSMUST00000153784; ENSMUSP00000116634; ENSMUSG00000053852 [B7ZCC9-1] ENSMUST00000154818; ENSMUSP00000119486; ENSMUSG00000053852 [B7ZCC9-2] |
Organism-specific databases
MGIi | MGI:2685213, Adgrg4 |
VEuPathDBi | HostDB:ENSMUSG00000053852 |
Phylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000162744 |
HOGENOMi | CLU_000643_0_0_1 |
InParanoidi | B7ZCC9 |
OMAi | NFTTLPF |
PhylomeDBi | B7ZCC9 |
Miscellaneous databases
ChiTaRSi | Adgrg4, mouse |
PROi | PR:B7ZCC9 |
RNActi | B7ZCC9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053852, Expressed in proximal tubule and 34 other tissues |
ExpressionAtlasi | B7ZCC9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR001759, Pentraxin-related |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00303, GPS, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS51828, PTX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AGRG4_MOUSE | |
Accessioni | B7ZCC9Primary (citable) accession number: B7ZCC9 Secondary accession number(s): B7ZCD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 22, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 23, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families