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UniProtKB - B7ZCC9 (AGRG4_MOUSE)

Protein

Adhesion G-protein coupled receptor G4

Gene

Adgrg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Orphan receptor.

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.014

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G4
Alternative name(s):
G-protein coupled receptor 112
Gene namesi
Name:Adgrg4
Synonyms:Gpr112
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2685213 Adgrg4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 2691ExtracellularCuratedAdd BLAST2666
Transmembranei2692 – 2712Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2713 – 2728CytoplasmicCuratedAdd BLAST16
Transmembranei2729 – 2749Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2750 – 2755ExtracellularCurated6
Transmembranei2756 – 2776Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2777 – 2798CytoplasmicCuratedAdd BLAST22
Transmembranei2799 – 2819Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2820 – 2842ExtracellularCuratedAdd BLAST23
Transmembranei2843 – 2863Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2864 – 2892CytoplasmicCuratedAdd BLAST29
Transmembranei2893 – 2913Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2914ExtracellularCurated1
Transmembranei2915 – 2935Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2936 – 3073CytoplasmicCuratedAdd BLAST138

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000038547726 – 3073Adhesion G-protein coupled receptor G4Add BLAST3048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 123PROSITE-ProRule annotation
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi662N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1495N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiB7ZCC9
PeptideAtlasiB7ZCC9
PRIDEiB7ZCC9

PTM databases

iPTMnetiB7ZCC9
PhosphoSitePlusiB7ZCC9

Expressioni

Gene expression databases

BgeeiENSMUSG00000053852 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiB7ZCC9 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116634

Structurei

3D structure databases

ProteinModelPortaliB7ZCC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 228Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST200
Domaini2632 – 2683GPSPROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1567 – 1570Poly-Ser4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
HOGENOMiHOG000230882
InParanoidiB7ZCC9
OrthoDBiEOG091G00P5

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B7ZCC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKHILHQRL CGLILVSSFI FLTDSLSLKG KRLDFYGEGK AYVSLTYTMP 
        60         70         80         90        100
ELSRLTACID LISMTNSSHY WMAFIYITNN TLLGREDVDL GLAGDHQQLI 
       110        120        130        140        150
LYSFGKTFYV SYHLIPFHWH TLCLVWDGVK GRLELFRNKE RILAIMDQPH 
       160        170        180        190        200
RLSPNGTLVL GHFPRNGEGQ IKTVIPRFTS SLYYFQLWDR ILENEEFMTC 
       210        220        230        240        250
FYGNVVSWED DVWLIHKISP TVDRRLRCFV SENMTIQETS TNVSQQIDLT 
       260        270        280        290        300
TSSQTTGLNP HKTSHSSTLL PEGMADSTIN STAISYANTV PSPLATVSAA 
       310        320        330        340        350
KDLKTSTTET ATFLTDTLFT STATPLPTQT VTEHSYLGKT RTSKRVEAMA 
       360        370        380        390        400
TEIFHSATAT DLIDTSVFTK NYTVSETSTT KSKSAVGKTT LFLNESTSIA 
       410        420        430        440        450
PTPCPKHKST DVAILHTSKS GQEFLVSSAA RTVSWSTLEE TSPITTDVGI 
       460        470        480        490        500
VSTFPPESLL TSTASPVSST FPEIQLASTL STTDSEMAST VHSVLPMQTI 
       510        520        530        540        550
PTPRTVKPES GSTNFQDVFS PSMEDALSVS MPKETTFMAF SSITSSPITR 
       560        570        580        590        600
TQDEQIAIDA ESTHLTIIPG TKFVPTLAEA SLFPTIEGQA YTQDTPTTDE 
       610        620        630        640        650
PMLTLTSTKS PSTYNASESV LTSITIKSDY QFFTNETTWT SKSGQNLLTS 
       660        670        680        690        700
MNTTTIPTFT SNKTLTLPFQ GNATNRDHSS MTTNVSPIEA STESKVTTSS 
       710        720        730        740        750
DATTASYTTA LFKPTSQWLS HFTSVSGITS IASQPESKLT TLLLKSNSMP 
       760        770        780        790        800
TVATNEFPSI PSEPVAPSVN TSTLTDIKPN FSTEKSISET IQIETNGVSS 
       810        820        830        840        850
FGDTLAPLPM SATTQRVYTT VTKETTSRHP KVKSTISTVA EASPFSTMLE 
       860        870        880        890        900
VTDESEQMVT ASVTISPFTD IEKLTTALSK ETATAEVGVS WLSTKLKESM 
       910        920        930        940        950
PESSHNGTTE SFNSTHTYTV DWTSEKSKGN SASSPNSAST QALPELPSSS 
       960        970        980        990       1000
TMKTMGVTFS TNSSQRTAAS LSAGILSPQT ASTHALVTPQ LLTHTFSLPV 
      1010       1020       1030       1040       1050
NISAVTSPKT TMVFFDETKV TLSQPSTLAR DFTTSMPSVG STLPTVTMTT 
      1060       1070       1080       1090       1100
ELVPPVSPTA STISDSMFTH RDLLHTTSEV TTISSTTAHM AISSLRETLV 
      1110       1120       1130       1140       1150
SSLRPPTPVI TKAISTIPSI SSDSVSPSIH TLVCSRPSPN NVTIVSSTYV 
      1160       1170       1180       1190       1200
SSTTSTSVAT PSESHFSFPY AFSSGGDVTM ASGPTGTSAG GEAMPPNTFV 
      1210       1220       1230       1240       1250
NKFITSVDHE STTYFVNTPV STQSVFATSM VSSDKEQTNI SMEKTLRTTG 
      1260       1270       1280       1290       1300
VAEISPSKNS FILDSQSTFP WEMTDTELSE TTEISSHQTH LPSEILPGYS 
      1310       1320       1330       1340       1350
DSGNLTTFST SGSTQSAQTL SSSTIIGVRV SEGSTSLEKT ALPSQVQTVT 
      1360       1370       1380       1390       1400
KSLTHDKERT SALSEYPPRT VEKIMSSSPV THQATGHLAT SIVDASRTTR 
      1410       1420       1430       1440       1450
ISHPVLINTT LSYLLSLKTK PEATQIASST SGSTENFPNS FSPFTTGLLS 
      1460       1470       1480       1490       1500
TNFTMITPNG STTVLSIPNE PTNLPKKTSM EASTPISQMD LLALNVTAFT 
      1510       1520       1530       1540       1550
SKKVSDTHTM LMTKSSRTIH IGTLKSVSIG TFGLKSEKSE MPVNNSDFST 
      1560       1570       1580       1590       1600
TVLYSDTSTR LGEFFTSSSS LPPKATKTTQ ASTLNTTPVA HAGPTSQRTV 
      1610       1620       1630       1640       1650
FSSTFSNSSV VEVPLNYTTA HFSSPTQRGF LSMKTIPTTS MAGISTSVIG 
      1660       1670       1680       1690       1700
ATSSSLSSSK NTEPISSIPK TMFSLLLSTT QQPSQENGAP TLDILPGITV 
      1710       1720       1730       1740       1750
SSGGATDLIN ANSRATIPAN ELSTTPSDNF YTFLNTQDSP TLTNSKVTPR 
      1760       1770       1780       1790       1800
PTESVKSTPT HLSFDTRKMN ILTELTKSGP CVTTPVLYPL WTQTSTAPPL 
      1810       1820       1830       1840       1850
TSHLYSPHST KAKFPLASQM AEYPAWATGI TPSITQALLT TSRNTQRVED 
      1860       1870       1880       1890       1900
SPFPVFTTKV MTPNRMEVET LHSPSGTLAT STTSQIGLVS RDVTVMPLIS 
      1910       1920       1930       1940       1950
TSESLPSLGI SESTSLSISS TFPPTTLAAI LPTFEKTAMP VTPGITLSSN 
      1960       1970       1980       1990       2000
PSVNSRATSP TWSSSSLPSD SRASIFTPSR LLTSSSGEMS ESTFPASDII 
      2010       2020       2030       2040       2050
ATYSNFTVAP LSDGSATIAT QATSTTTLDI ITANSLTSPP IPSKDKDGSL 
      2060       2070       2080       2090       2100
HTSTFLESSL RTTGADSSTD MSERMSFGRT SISPSLTRHD LSIGSLTVSS 
      2110       2120       2130       2140       2150
PTNTSPWSKV PVTSESHTLF PSKSTLDSVM STATTTSTAI GTSFPLMSTE 
      2160       2170       2180       2190       2200
MAHPSTATGF SLVSSSFETT WMDSIFSSLF TQPSTSPTAK ESTVSFYNIK 
      2210       2220       2230       2240       2250
MSFSVFDEEP RVLVTTVIHD LTKDWLNFMF QNSEFSLANL AIQIKSRKTS 
      2260       2270       2280       2290       2300
KEETAMYRYI LEQKKGQGMD AIFHVPYSCA CWVIIKAKSS LESVELISSI 
      2310       2320       2330       2340       2350
RTKIHGNLTH GNFTQDQLTL LVKSDHVVVE KLEPGKCEAD ETPSKYKGTY 
      2360       2370       2380       2390       2400
KWPLTDPTET AQERCIKNEN RNATRICSIS IQTGKCQWEK PRLKQCKLLQ 
      2410       2420       2430       2440       2450
GLPDKIVDLA NITISDENAD DVAEHILNLV NESPPLDEEE TKIIVSKVAD 
      2460       2470       2480       2490       2500
ISNCDEISIN LTQIILQILN TVTEKQSDSA SNLPPVSNEI LRIIERVGHK 
      2510       2520       2530       2540       2550
MEFAGRTANL TVAKLALAVL RVDHKFEGMA FSIQSSEEVI APQIFLGDIP 
      2560       2570       2580       2590       2600
LRKALASIYL PKSLREKVPL DGLQTILFNF FGQTSLFKAK TITSELMTYV 
      2610       2620       2630       2640       2650
VSASISNTSI QNLADPVIII LKHIQGDWNY DQVYCAFWDF DTNNGLGGWN 
      2660       2670       2680       2690       2700
PSGCKLKESN INYTICQCNH LTHFGVLMDL SRSTVDAVNE RILVIITYTG 
      2710       2720       2730       2740       2750
CGISSIFLGI AMVTYIAFHK LRKDYPSKIL INLCTALLML NLAFLVNSWL 
      2760       2770       2780       2790       2800
TSFQKVGLCI TAAVALHYFL LVSLTWMGLE AVHMYFALVK VFNTYIPNYI 
      2810       2820       2830       2840       2850
LKFCLAGWGI PAITVAIILS VRKDLYGTLS PTTPFCWIKD DHIFYISVVA 
      2860       2870       2880       2890       2900
YFCLIFLMNL SMFCTVLVQL TSVKSQSQKT RKKMILNDLK GTISLTFLLG 
      2910       2920       2930       2940       2950
LTWGFAFFAW GPVRIFFLYL FAICNTLQGF LIFVFYCVMK ESVREQWHMP 
      2960       2970       2980       2990       3000
LHCRWLRLEN FAGWINVRHK QKRLKKNNES KLLTPSLMST TTFKSIGSVP 
      3010       3020       3030       3040       3050
SIPSEINFSN GDFDDSPDTF SFLSCKAAPT FIRRALPAEI QTNSTQKQRS 
      3060       3070 
FPINVSRDTH LTPSSGLGEM FNL
Length:3,073
Mass (Da):334,211
Last modified:March 3, 2009 - v1
Checksum:iED17E7ED8D55EBDA
GO
Isoform 2 (identifier: B7ZCC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: D → V
     25-229: Missing.

Note: No experimental confirmation available.
Show »
Length:2,868
Mass (Da):310,201
Checksum:i39CBEC343C4323F9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UNS7Q3UNS7_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg4 Gpr112, mCG_118915
216Annotation score:
B7ZCD1B7ZCD1_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg4
2,736Annotation score:
F6Y0G3F6Y0G3_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg4
205Annotation score:
Q80T58Q80T58_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg4 Gpr112
177Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03817724D → V in isoform 2. Curated1
Alternative sequenceiVSP_03817825 – 229Missing in isoform 2. CuratedAdd BLAST205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672263, AL671998 Genomic DNA Translation: CAX16065.1
AL672263, AL671998 Genomic DNA Translation: CAX16066.1
AL671998, AL672263 Genomic DNA Translation: CAX16092.1
AL671998, AL672263 Genomic DNA Translation: CAX16093.1
UniGeneiMm.35282

Genome annotation databases

EnsembliENSMUST00000153784; ENSMUSP00000116634; ENSMUSG00000053852 [B7ZCC9-1]
ENSMUST00000154818; ENSMUSP00000119486; ENSMUSG00000053852 [B7ZCC9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672263, AL671998 Genomic DNA Translation: CAX16065.1
AL672263, AL671998 Genomic DNA Translation: CAX16066.1
AL671998, AL672263 Genomic DNA Translation: CAX16092.1
AL671998, AL672263 Genomic DNA Translation: CAX16093.1
UniGeneiMm.35282

3D structure databases

ProteinModelPortaliB7ZCC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116634

Protein family/group databases

MEROPSiP02.014
GPCRDBiSearch...

PTM databases

iPTMnetiB7ZCC9
PhosphoSitePlusiB7ZCC9

Proteomic databases

PaxDbiB7ZCC9
PeptideAtlasiB7ZCC9
PRIDEiB7ZCC9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000153784; ENSMUSP00000116634; ENSMUSG00000053852 [B7ZCC9-1]
ENSMUST00000154818; ENSMUSP00000119486; ENSMUSG00000053852 [B7ZCC9-2]

Organism-specific databases

MGIiMGI:2685213 Adgrg4

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
HOGENOMiHOG000230882
InParanoidiB7ZCC9
OrthoDBiEOG091G00P5

Miscellaneous databases

PROiPR:B7ZCC9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053852 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiB7ZCC9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG4_MOUSE
AccessioniPrimary (citable) accession number: B7ZCC9
Secondary accession number(s): B7ZCD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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