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Protein

Kinesin-like protein KIF28P

Gene

KIF28P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Microtubule-dependent motor protein required for mitochondrion morhology and transport of mitochondria in neuronal cells.By similarity

Caution

The sequence of the protein was deduced from the genomic sequence and ESTs by similarity to the mouse and rat sequence.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi111 – 118ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF28P
Alternative name(s):
Kinesin-like protein 6
Gene namesi
Name:KIF28P
Synonyms:KLP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:49205 KIF28P
neXtProtiNX_B7ZC32

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi100130097

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004155691 – 967Kinesin-like protein KIF28PAdd BLAST967

Proteomic databases

PRIDEiB7ZC32
ProteomicsDBi7170

PTM databases

iPTMnetiB7ZC32
PhosphoSitePlusiB7ZC32
SwissPalmiB7ZC32

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB7ZC32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 355Kinesin motorPROSITE-ProRule annotationAdd BLAST349
Domaini410 – 472FHAAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili822 – 851Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000200518
InParanoidiB7ZC32

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR027640 Kinesin-like_fam
IPR022140 Kinesin-like_KIF1-typ
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 2 hits
PfamiView protein in Pfam
PF12423 KIF1B, 1 hit
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

B7ZC32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTQSVDSVK AVRVRPFSQR EKNSGSKCVI SMHSRTTTTT QDPKNPEHVK
60 70 80 90 100
TFTFDLAYWS HNGFQRDKDG VLISADPSRK FAGQRDVFHD LGRGILDSAW
110 120 130 140 150
QGYNATLLAY GQTGSGKSYS MIGFGCKQGI IPTVCEELFR AIENQGRNQE
160 170 180 190 200
HQVMFSMLEI YKEIIRDLLS RTKKPGGLRI REDQQLGFYV EGLKSVPCEN
210 220 230 240 250
YAQIERLMEQ GTKIRTTAST NMNASSSRSH LVITIQFKQV FLDRDLTKQS
260 270 280 290 300
SINLVDLARS ERQKSSGSEG DRLREGSCVN LSLTNLGSVI SVLADAAMGK
310 320 330 340 350
KVLHIPYRDS VLTKLLQSAL GGNSRTALVA AVSPADICYE ETLSTLRYAE
360 370 380 390 400
RERKIRNRAV ANTWTLMRKS RAENSKLLPM MTFPHLLNLS EDPQLTRVLK
410 420 430 440 450
YFIQAGTQPA PCPRPALSPP HPALRISDKH ASFTNADGKV TVTPHSKCKV
460 470 480 490 500
AVNGVPITTR TKLQHLDRLI LGSNSTYLYV GFPSEWGSED LSRFDYDFFQ
510 520 530 540 550
LERAAAEGAS ADKLGAADGG DGKAGPSVLA AFQDYIKLMP LVSEANQMSE
560 570 580 590 600
EPKKGLNMEL KVKNLASSDS RGYDLQKEVL VKVTHHGSHE VWIWSKAKFI
610 620 630 640 650
NRKFLMQELY QRFLDGDHGP VARDDDPFWD PVEVVRLGSA HIWLQSLAYC
660 670 680 690 700
MKLEEQVEFL NCDGLEEAVL HTCIAPCSPT GQTHGEEDVV IDPLELLGKR
710 720 730 740 750
MDFQIHIVRC LGVNWMKEDA KRGTQIGYRI YDLPNTIYTK PVWKSVNPQI
760 770 780 790 800
EETVQFAALT ASQEFLNYLR TNALIVDLWG LQEGCTELSC SQLGLMVTGE
810 820 830 840 850
GHILVDTKKI STVKDISQAA SNQIPELYLK LLKLEQETEP LRNINRALRE
860 870 880 890 900
ENVLLKASLA KTASGQAPKP SNTLKISGMT AQLPSAGEMS QMCTQQAGSD
910 920 930 940 950
RELAKALKVF YQSMNTARGQ LFRLRRHQPP EVDQMLRPFI HQRSQMFKDL
960
GDLRESSLWT LKMTLLL
Length:967
Mass (Da):108,254
Last modified:February 22, 2012 - v2
Checksum:iD87C3E911441DDE6
GO

Sequence cautioni

The sequence CAX12164 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113174 Genomic DNA No translation available.
AL591848 Genomic DNA Translation: CAX12164.1 Sequence problems.
UniGeneiHs.739045

Similar proteinsi

Entry informationi

Entry nameiKIF28_HUMAN
AccessioniPrimary (citable) accession number: B7ZC32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 20, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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