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Protein

Protein phosphatase 1 regulatory subunit 3G

Gene

PPP1R3G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3G
Gene namesi
Name:PPP1R3G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000219607.3
HGNCiHGNC:14945 PPP1R3G
neXtProtiNX_B7ZBB8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000219607
PharmGKBiPA33657

Polymorphism and mutation databases

BioMutaiPPP1R3G

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003949651 – 358Protein phosphatase 1 regulatory subunit 3GAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB7ZBB8
PRIDEiB7ZBB8
ProteomicsDBi7109

PTM databases

iPTMnetiB7ZBB8
PhosphoSitePlusiB7ZBB8

Expressioni

Gene expression databases

BgeeiENSG00000219607 Expressed in 77 organ(s), highest expression level in apex of heart

Organism-specific databases

HPAiHPA056393

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi572922, 1 interactor
IntActiB7ZBB8, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliB7ZBB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 350CBM21PROSITE-ProRule annotationAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 105Poly-Gln6
Compositional biasi182 – 188Poly-Ala7

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00530000062978
HOGENOMiHOG000082433
HOVERGENiHBG106533
InParanoidiB7ZBB8
OMAiTEWRSFL
OrthoDBiEOG091G0FLS
PhylomeDBiB7ZBB8
TreeFamiTF105537

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit

Sequencei

Sequence statusi: Complete.

B7ZBB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPIGARLSL EAPGPAPFRE APPAEELPAP VVPCVQGGGD GGGASETPSP
60 70 80 90 100
DAQLGDRPLS PKEEAAPQEQ EELLECRRRC RARSFSLPAD PILQAAKFLQ
110 120 130 140 150
QQQQQAVALG GEGAEDAQLG PGGCCAKCKK RVQFADTLGL SLASVKHFSE
160 170 180 190 200
AEEPQVPPAV LSRLRSFPMR AEDLEQLGGL LAAAAVAAPL SAPPSRLRPL
210 220 230 240 250
FQLPGPSAAA ERLQRQRVCL ERVQCSTASG AEVKGSGRVL SCPGPRAVTV
260 270 280 290 300
RYTFTEWRSF LDVPAELQPE PLEPQQPEAP SGASEPGSGD AKKEPGAECF
310 320 330 340 350
HFSLCLPPGL QPEDEEDADE RGVAVHFAVC YRCAQGEYWD NNAGANYTLR

YARPADAL
Length:358
Mass (Da):38,019
Last modified:March 3, 2009 - v1
Checksum:i8976D05A4FA43F1F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063262280P → Q. Corresponds to variant dbSNP:rs436556Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035653 Genomic DNA No translation available.
CCDSiCCDS47366.1
RefSeqiNP_001138587.1, NM_001145115.2
UniGeneiHs.653089

Genome annotation databases

EnsembliENST00000405617; ENSP00000393832; ENSG00000219607
GeneIDi648791
KEGGihsa:648791
UCSCiuc011dia.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035653 Genomic DNA No translation available.
CCDSiCCDS47366.1
RefSeqiNP_001138587.1, NM_001145115.2
UniGeneiHs.653089

3D structure databases

ProteinModelPortaliB7ZBB8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi572922, 1 interactor
IntActiB7ZBB8, 1 interactor

PTM databases

iPTMnetiB7ZBB8
PhosphoSitePlusiB7ZBB8

Polymorphism and mutation databases

BioMutaiPPP1R3G

Proteomic databases

PaxDbiB7ZBB8
PRIDEiB7ZBB8
ProteomicsDBi7109

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405617; ENSP00000393832; ENSG00000219607
GeneIDi648791
KEGGihsa:648791
UCSCiuc011dia.2 human

Organism-specific databases

CTDi648791
EuPathDBiHostDB:ENSG00000219607.3
GeneCardsiPPP1R3G
HGNCiHGNC:14945 PPP1R3G
HPAiHPA056393
neXtProtiNX_B7ZBB8
OpenTargetsiENSG00000219607
PharmGKBiPA33657
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00530000062978
HOGENOMiHOG000082433
HOVERGENiHBG106533
InParanoidiB7ZBB8
OMAiTEWRSFL
OrthoDBiEOG091G0FLS
PhylomeDBiB7ZBB8
TreeFamiTF105537

Miscellaneous databases

GenomeRNAii648791
PROiPR:B7ZBB8

Gene expression databases

BgeeiENSG00000219607 Expressed in 77 organ(s), highest expression level in apex of heart

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPP13G_HUMAN
AccessioniPrimary (citable) accession number: B7ZBB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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