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Protein

Golgi pH regulator A

Gene

GPR89A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.By similarity2 Publications

Miscellaneous

Does not seem to be able to bind GTP.

GO - Molecular functioni

  • voltage-gated anion channel activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi pH regulator A
Alternative name(s):
Protein GPR89A
Putative MAPK-activating protein PM01
Putative NF-kappa-B-activating protein 90
Gene namesi
Name:GPR89A
Synonyms:GPHRA, GPR89, SH120
ORF Names:CGI-13, UNQ192/PRO218
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117262.18
HGNCiHGNC:31984 GPR89A
MIMi612821 gene
neXtProtiNX_B7ZAQ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134986137

Polymorphism and mutation databases

BioMutaiGPR89A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232601 – 455Golgi pH regulator AAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiB7ZAQ6
PaxDbiB7ZAQ6
PRIDEiB7ZAQ6
ProteomicsDBi7077
7078 [B7ZAQ6-2]
7079 [B7ZAQ6-3]

PTM databases

iPTMnetiB7ZAQ6
PhosphoSitePlusiB7ZAQ6
SwissPalmiB7ZAQ6

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000117262 Expressed in 90 organ(s), highest expression level in intestine
ExpressionAtlasiB7ZAQ6 baseline and differential
GenevisibleiB7ZAQ6 HS

Organism-specific databases

HPAiHPA076096

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi119554, 21 interactors
575849, 55 interactors
IntActiB7ZAQ6, 5 interactors
STRINGi9606.ENSP00000358233

Structurei

3D structure databases

ProteinModelPortaliB7ZAQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2417 Eukaryota
ENOG410XQ8R LUCA
GeneTreeiENSGT00390000000684
HOVERGENiHBG054909
InParanoidiB7ZAQ6
KOiK22193
OMAiHFNFYHR
PhylomeDBiB7ZAQ6
TreeFamiTF313484

Family and domain databases

InterProiView protein in InterPro
IPR025969 ABA_GPCR_dom
IPR022535 Golgi_pH-regulator_cons_dom
IPR015672 GPHR/GTG
PANTHERiPTHR15948 PTHR15948, 1 hit
PfamiView protein in Pfam
PF12430 ABA_GPCR, 1 hit
PF12537 GPHR_N, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B7ZAQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF
60 70 80 90 100
SCTMFELIIF EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS
110 120 130 140 150
NIRLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV
160 170 180 190 200
GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI
210 220 230 240 250
ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG SENLTLIQQE
260 270 280 290 300
VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK
310 320 330 340 350
IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI
360 370 380 390 400
IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM
410 420 430 440 450
SMPLEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE

KQMAP
Length:455
Mass (Da):52,917
Last modified:June 15, 2010 - v2
Checksum:iD831F66E682643F9
GO
Isoform 2 (identifier: B7ZAQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Show »
Length:335
Mass (Da):38,484
Checksum:iAC5F09C2DA129937
GO
Isoform 3 (identifier: B7ZAQ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Show »
Length:430
Mass (Da):49,986
Checksum:i60065DCCB3B1A31B
GO
Isoform 4 (identifier: B7ZAQ6-4) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     106-124: HKQRLLFSCLLWLTFMYFF → LSPLSQCINNDCFFPVSYG
     125-455: Missing.

Show »
Length:124
Mass (Da):14,650
Checksum:iB2C6CE7C583F0DD2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKY3E9PKY3_HUMAN
Golgi pH regulator A
GPR89A
229Annotation score:
E9PRZ5E9PRZ5_HUMAN
Golgi pH regulator A
GPR89A
55Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100S → G in BAG63359 (PubMed:14702039).Curated1
Sequence conflicti243N → MPD in BAD96943 (Ref. 7) Curated1
Sequence conflicti379I → T in BAD96943 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0172471 – 120Missing in isoform 2. 2 PublicationsAdd BLAST120
Alternative sequenceiVSP_0393461 – 25Missing in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_055892106 – 124HKQRL…FMYFF → LSPLSQCINNDCFFPVSYG in isoform 4. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_055893125 – 455Missing in isoform 4. 2 PublicationsAdd BLAST331

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132947 mRNA Translation: AAD27722.1
KJ535049 mRNA Translation: AHW56688.1
AY358966 mRNA Translation: AAQ89325.1
AB097024 mRNA Translation: BAC77377.1
AB097025 mRNA Translation: BAC77378.1
BT006679 mRNA Translation: AAP35325.1
AK021758 mRNA Translation: BAG51045.1
AK297145 mRNA Translation: BAG59645.1
AK301939 mRNA Translation: BAG63359.1
AK316371 mRNA Translation: BAH14742.1
AK223223 mRNA Translation: BAD96943.1
AL390725, BX511042, CR628408 Genomic DNA Translation: CAI13712.2
BX511042, AL390725, CR628408 Genomic DNA Translation: CAI13224.2
CR628408, AL390725, BX511042 Genomic DNA Translation: CAM28366.1
BC003187 mRNA Translation: AAH03187.1
BC067816 mRNA Translation: AAH67816.1
BC146880 mRNA Translation: AAI46881.1
CCDSiCCDS72857.1 [B7ZAQ6-1]
CCDS72858.1 [B7ZAQ6-3]
RefSeqiNP_001091081.1, NM_001097612.1 [B7ZAQ6-1]
NP_001091082.2, NM_001097613.2 [B7ZAQ6-3]
NP_057418.1, NM_016334.3 [B7ZAQ6-1]
XP_005277458.1, XM_005277401.3
XP_005277459.1, XM_005277402.4 [B7ZAQ6-3]
XP_005277461.1, XM_005277404.3
XP_006711440.1, XM_006711377.3
XP_006711441.1, XM_006711378.2
XP_006711555.1, XM_006711492.3 [B7ZAQ6-1]
XP_006711556.1, XM_006711493.3 [B7ZAQ6-2]
XP_011507912.1, XM_011509610.2
XP_011507914.1, XM_011509612.2 [B7ZAQ6-2]
XP_011508210.1, XM_011509908.2 [B7ZAQ6-3]
XP_011508211.1, XM_011509909.2 [B7ZAQ6-3]
XP_016856937.1, XM_017001448.1 [B7ZAQ6-3]
UniGeneiHs.504320
Hs.559115
Hs.645432

Genome annotation databases

EnsembliENST00000313835; ENSP00000319673; ENSG00000117262 [B7ZAQ6-1]
ENST00000460277; ENSP00000436705; ENSG00000117262 [B7ZAQ6-4]
ENST00000462900; ENSP00000432248; ENSG00000117262 [B7ZAQ6-3]
ENST00000528944; ENSP00000434108; ENSG00000117262 [B7ZAQ6-4]
ENST00000534502; ENSP00000434495; ENSG00000117262 [B7ZAQ6-3]
GeneIDi51463
653519
KEGGihsa:51463
hsa:653519
UCSCiuc010ozb.2 human [B7ZAQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132947 mRNA Translation: AAD27722.1
KJ535049 mRNA Translation: AHW56688.1
AY358966 mRNA Translation: AAQ89325.1
AB097024 mRNA Translation: BAC77377.1
AB097025 mRNA Translation: BAC77378.1
BT006679 mRNA Translation: AAP35325.1
AK021758 mRNA Translation: BAG51045.1
AK297145 mRNA Translation: BAG59645.1
AK301939 mRNA Translation: BAG63359.1
AK316371 mRNA Translation: BAH14742.1
AK223223 mRNA Translation: BAD96943.1
AL390725, BX511042, CR628408 Genomic DNA Translation: CAI13712.2
BX511042, AL390725, CR628408 Genomic DNA Translation: CAI13224.2
CR628408, AL390725, BX511042 Genomic DNA Translation: CAM28366.1
BC003187 mRNA Translation: AAH03187.1
BC067816 mRNA Translation: AAH67816.1
BC146880 mRNA Translation: AAI46881.1
CCDSiCCDS72857.1 [B7ZAQ6-1]
CCDS72858.1 [B7ZAQ6-3]
RefSeqiNP_001091081.1, NM_001097612.1 [B7ZAQ6-1]
NP_001091082.2, NM_001097613.2 [B7ZAQ6-3]
NP_057418.1, NM_016334.3 [B7ZAQ6-1]
XP_005277458.1, XM_005277401.3
XP_005277459.1, XM_005277402.4 [B7ZAQ6-3]
XP_005277461.1, XM_005277404.3
XP_006711440.1, XM_006711377.3
XP_006711441.1, XM_006711378.2
XP_006711555.1, XM_006711492.3 [B7ZAQ6-1]
XP_006711556.1, XM_006711493.3 [B7ZAQ6-2]
XP_011507912.1, XM_011509610.2
XP_011507914.1, XM_011509612.2 [B7ZAQ6-2]
XP_011508210.1, XM_011509908.2 [B7ZAQ6-3]
XP_011508211.1, XM_011509909.2 [B7ZAQ6-3]
XP_016856937.1, XM_017001448.1 [B7ZAQ6-3]
UniGeneiHs.504320
Hs.559115
Hs.645432

3D structure databases

ProteinModelPortaliB7ZAQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119554, 21 interactors
575849, 55 interactors
IntActiB7ZAQ6, 5 interactors
STRINGi9606.ENSP00000358233

PTM databases

iPTMnetiB7ZAQ6
PhosphoSitePlusiB7ZAQ6
SwissPalmiB7ZAQ6

Polymorphism and mutation databases

BioMutaiGPR89A

Proteomic databases

EPDiB7ZAQ6
PaxDbiB7ZAQ6
PRIDEiB7ZAQ6
ProteomicsDBi7077
7078 [B7ZAQ6-2]
7079 [B7ZAQ6-3]

Protocols and materials databases

DNASUi51463
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313835; ENSP00000319673; ENSG00000117262 [B7ZAQ6-1]
ENST00000460277; ENSP00000436705; ENSG00000117262 [B7ZAQ6-4]
ENST00000462900; ENSP00000432248; ENSG00000117262 [B7ZAQ6-3]
ENST00000528944; ENSP00000434108; ENSG00000117262 [B7ZAQ6-4]
ENST00000534502; ENSP00000434495; ENSG00000117262 [B7ZAQ6-3]
GeneIDi51463
653519
KEGGihsa:51463
hsa:653519
UCSCiuc010ozb.2 human [B7ZAQ6-1]

Organism-specific databases

CTDi51463
653519
EuPathDBiHostDB:ENSG00000117262.18
GeneCardsiGPR89A
HGNCiHGNC:31984 GPR89A
HPAiHPA076096
MIMi612821 gene
neXtProtiNX_B7ZAQ6
PharmGKBiPA134986137
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2417 Eukaryota
ENOG410XQ8R LUCA
GeneTreeiENSGT00390000000684
HOVERGENiHBG054909
InParanoidiB7ZAQ6
KOiK22193
OMAiHFNFYHR
PhylomeDBiB7ZAQ6
TreeFamiTF313484

Miscellaneous databases

ChiTaRSiGPR89A human
GeneWikiiGPR89B
PROiPR:B7ZAQ6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117262 Expressed in 90 organ(s), highest expression level in intestine
ExpressionAtlasiB7ZAQ6 baseline and differential
GenevisibleiB7ZAQ6 HS

Family and domain databases

InterProiView protein in InterPro
IPR025969 ABA_GPCR_dom
IPR022535 Golgi_pH-regulator_cons_dom
IPR015672 GPHR/GTG
PANTHERiPTHR15948 PTHR15948, 1 hit
PfamiView protein in Pfam
PF12430 ABA_GPCR, 1 hit
PF12537 GPHR_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPHRA_HUMAN
AccessioniPrimary (citable) accession number: B7ZAQ6
Secondary accession number(s): A6NN37
, B2RUV3, B3KMN3, B4DLT3, B4DXE7, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: September 12, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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