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Protein

Rab GTPase-activating protein 1-like, isoform 10

Gene

RABGAP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab GTPase-activating protein 1-like, isoform 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RABGAP1L
Synonyms:HHL, KIAA0471
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000152061.22

Human Gene Nomenclature Database

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HGNCi
HGNC:24663 RABGAP1L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_B7ZAP0

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9910

Open Targets

More...
OpenTargetsi
ENSG00000152061

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CACNA1B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004176131 – 253Rab GTPase-activating protein 1-like, isoform 10Add BLAST253

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
B7ZAP0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
7075

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B7ZAP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B7ZAP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152061 Expressed in 231 organ(s), highest expression level in cardiac atrium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B7ZAP0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B7ZAP0 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115239, 79 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
B7ZAP0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
B7ZAP0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili8 – 222Sequence analysisAdd BLAST215

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154611

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG068503

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 10 (identifier: B7ZAP0-1) [UniParc]FASTAAdd to basket
Also known as: D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIENSSWSMT FEERENRRLQ EASMRLEQEN DDLAHELVTS KIALRNDLDQ
60 70 80 90 100
AEDKADVLNK ELLLTKQRLV ETEEEKRKQE EETAQLKEVF RKQLEKAEYE
110 120 130 140 150
IKKTTAIIAE YKQICSQLST RLEKQQAASK EELEVVKGKM MACKHCSDIF
160 170 180 190 200
SKEGALKLAA TGREDQGIET DDEKDSLKKQ LREMELELAQ TKLQLVEAKC
210 220 230 240 250
KIQELEHQRG ALMNEIQAAK NSWFSKTLNS IKTATGTQPL QPAPVTQPPK

EST
Length:253
Mass (Da):29,038
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F7A7E4D6197856C
GO
Isoform 1 (identifier: Q5R372-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:815
Mass (Da):92,513
GO
Isoform 2 (identifier: Q5R372-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:605
Mass (Da):68,003
GO
Isoform 3 (identifier: Q5R372-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:827
Mass (Da):94,002
GO
Isoform 4 (identifier: Q5R372-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:800
Mass (Da):90,838
GO
Isoform 5 (identifier: Q5R372-5) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:378
Mass (Da):43,888
GO
Isoform 6 (identifier: Q5R372-6) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:377
Mass (Da):43,760
GO
Isoform 7 (identifier: Q5R372-7) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:358
Mass (Da):41,545
GO
Isoform 8 (identifier: Q5R372-8) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:370
Mass (Da):42,689
GO
Isoform 9 (identifier: Q5R372-9) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:72
Mass (Da):8,667
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti89V → A in BAH14590 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK316219 mRNA Translation: BAH14590.1
AK316355 mRNA Translation: BAH14726.1
AL008735 Genomic DNA No translation available.
AL021069 Genomic DNA No translation available.
AL022171 Genomic DNA No translation available.
AL022400 Genomic DNA No translation available.
AL031278 Genomic DNA No translation available.
AL031286 Genomic DNA No translation available.
AL136377 Genomic DNA No translation available.
AL161671 Genomic DNA No translation available.
AL591108 Genomic DNA No translation available.
Z99127 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55662.1 [B7ZAP0-1]

NCBI Reference Sequences

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RefSeqi
NP_001230693.1, NM_001243764.1 [B7ZAP0-1]
XP_016858487.1, XM_017002998.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.585378
Hs.744937

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367688; ENSP00000356661; ENSG00000152061 [B7ZAP0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9910

UCSC genome browser

More...
UCSCi
uc010pmv.3 human [B7ZAP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316219 mRNA Translation: BAH14590.1
AK316355 mRNA Translation: BAH14726.1
AL008735 Genomic DNA No translation available.
AL021069 Genomic DNA No translation available.
AL022171 Genomic DNA No translation available.
AL022400 Genomic DNA No translation available.
AL031278 Genomic DNA No translation available.
AL031286 Genomic DNA No translation available.
AL136377 Genomic DNA No translation available.
AL161671 Genomic DNA No translation available.
AL591108 Genomic DNA No translation available.
Z99127 Genomic DNA No translation available.
CCDSiCCDS55662.1 [B7ZAP0-1]
RefSeqiNP_001230693.1, NM_001243764.1 [B7ZAP0-1]
XP_016858487.1, XM_017002998.1
UniGeneiHs.585378
Hs.744937

3D structure databases

ProteinModelPortaliB7ZAP0
SMRiB7ZAP0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115239, 79 interactors

PTM databases

iPTMnetiB7ZAP0
PhosphoSitePlusiB7ZAP0

Polymorphism and mutation databases

BioMutaiCACNA1B

Proteomic databases

PRIDEiB7ZAP0
ProteomicsDBi7075

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367688; ENSP00000356661; ENSG00000152061 [B7ZAP0-1]
GeneIDi9910
KEGGihsa:9910
UCSCiuc010pmv.3 human [B7ZAP0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9910
DisGeNETi9910
EuPathDBiHostDB:ENSG00000152061.22

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RABGAP1L
HGNCiHGNC:24663 RABGAP1L
neXtProtiNX_B7ZAP0
OpenTargetsiENSG00000152061

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154611
HOVERGENiHBG068503

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RABGAP1L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9910

Gene expression databases

BgeeiENSG00000152061 Expressed in 231 organ(s), highest expression level in cardiac atrium
ExpressionAtlasiB7ZAP0 baseline and differential
GenevisibleiB7ZAP0 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBG10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7ZAP0
Secondary accession number(s): B7ZAA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: March 3, 2009
Last modified: December 5, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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