UniProtKB - B7Z9V1 (B7Z9V1_HUMAN)
Protein
Tyrosine-protein phosphatase non-receptor type
Gene
PTPN3
Organism
Homo sapiens (Human)
Status
Functioni
May act at junctions between the membrane and the cytoskeleton.UniRule annotation
Catalytic activityi
- EC:3.1.3.48UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 766 | SubstrateUniRule annotation | 1 | |
Active sitei | 797 | Phosphocysteine intermediateUniRule annotation | 1 | |
Binding sitei | 841 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- cytoskeletal protein binding Source: InterPro
- protein tyrosine phosphatase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase, Protein phosphataseUniRule annotation, ReceptorImported |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation) |
Gene namesi | Name:PTPN3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotationARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 312 | FERMInterPro annotationAdd BLAST | 284 | |
Domaini | 465 – 537 | PDZInterPro annotationAdd BLAST | 73 | |
Domaini | 601 – 856 | Tyrosine-protein phosphataseInterPro annotationAdd BLAST | 256 | |
Domaini | 774 – 847 | TYR_PHOSPHATASE_2InterPro annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 329 – 356 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 378 – 430 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 797 – 803 | Substrate bindingUniRule annotation | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 378 – 425 | PolarSequence analysisAdd BLAST | 48 |
Sequence similaritiesi
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.UniRule annotationARBA annotation
Phylogenomic databases
OrthoDBi | 96595at2759 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13189, FERM_C_PTPN4_PTPN3_like, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit 2.30.42.10, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR041783, PTPN3/4_FERM_C IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR012151, Tyr_Pase_non-rcpt_typ-3/4 IPR000387, TYR_PHOSPHATASE_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF00595, PDZ, 1 hit PF00102, Y_phosphatase, 1 hit |
PIRSFi | PIRSF000927, Tyr-Ptase_nr3, 2 hits |
PRINTSi | PR00935, BAND41 PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01196, FERM_C, 1 hit SM00228, PDZ, 1 hit SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF50156, SSF50156, 1 hit SSF52799, SSF52799, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit PS50106, PDZ, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
i Sequence
Sequence statusi: Complete.
B7Z9V1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSRLRALGG RINNIRTSEL PKEKTRSEVI CSIHFLDGVV QTFKVTKQDT
60 70 80 90 100
GQVLLDMVHN HLGVTEKEYF GLQHDDDSVD SPRWLEASKA IRKQLKGGFP
110 120 130 140 150
CTLHFRVRFF IPDPNTLQQE QTRHLYFLQL KMDICEGRLT CPLNSAVVLA
160 170 180 190 200
SYAVQSHFGD YNSSIHHPGY LSDSHFIPDQ NEDFLTKVES LHEQHSGLKQ
210 220 230 240 250
SEAESCYINI ARTLDFYGVE LHSGRDLHNL DLMIGIASAG VAVYRKYICT
260 270 280 290 300
SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS
310 320 330 340 350
CVEHHTFFQA KKLLPQEKNV LSQYWTMGSR NTKKRSPRLR HEIRKPRHSS
360 370 380 390 400
ADNLANEMTY ITETEDVFYT YKGSLAPQDS DSEVSQNRSP HQESLSENNP
410 420 430 440 450
AQSYLTQKSS SSVSPSSNAP GSCSPDGVDQ QLLDDFHRVT KGGSTEDASQ
460 470 480 490 500
YYCDKNDNGD SYLVLIRITP DEDGKFGFNL KGGVDQKMPL VVSRINPESP
510 520 530 540 550
ADTCIPKLNE GDQIVLINGR DISEHTHDQV VMFIKASRES HSRELALVIR
560 570 580 590 600
RRAVRSFADF KSEDELNQLF PEAIFPMCPE GGDTLEGSMA QLKKGLESGT
610 620 630 640 650
VLIQFEQLYR KKPGLAITFA KLPQNLDKNR YKDVLPYDTT RVLLQGNEDY
660 670 680 690 700
INASYVNMEI PAANLVNKYI ATQGPLPHTC AQFWQVVWDQ KLSLIVMLTT
710 720 730 740 750
LTERGRTKCH QYWPDPPDVM NHGGFHIQCQ SEDCTIAYVS REMLVTNTQT
760 770 780 790 800
GEEHTVTHLQ YVAWPDHGVP DDSSDFLEFV NYVRSLRVDS EPVLVHCSAG
810 820 830 840 850
IGRTGVLVTM ETAMCLTERN LPIYPLDIVR KMRDQRAMMV QTSSQYKFVC
860
EAILRVYEEG LVQMLDPS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC143848 mRNA Translation: AAI43849.1 AK316066 mRNA Translation: BAH14437.1 |
RefSeqi | NP_001138840.1, NM_001145368.1 NP_002820.3, NM_002829.3 |
Genome annotation databases
GeneIDi | 5774 |
KEGGi | hsa:5774 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC143848 mRNA Translation: AAI43849.1 AK316066 mRNA Translation: BAH14437.1 |
RefSeqi | NP_001138840.1, NM_001145368.1 NP_002820.3, NM_002829.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B7Z9V1 |
PeptideAtlasi | B7Z9V1 |
Protocols and materials databases
DNASUi | 5774 |
Genome annotation databases
GeneIDi | 5774 |
KEGGi | hsa:5774 |
Organism-specific databases
CTDi | 5774 |
PharmGKBi | PA33999 |
Phylogenomic databases
OrthoDBi | 96595at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5774, 3 hits in 872 CRISPR screens |
ChiTaRSi | PTPN3, human |
GenomeRNAii | 5774 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13189, FERM_C_PTPN4_PTPN3_like, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit 2.30.42.10, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR041783, PTPN3/4_FERM_C IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR012151, Tyr_Pase_non-rcpt_typ-3/4 IPR000387, TYR_PHOSPHATASE_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF00595, PDZ, 1 hit PF00102, Y_phosphatase, 1 hit |
PIRSFi | PIRSF000927, Tyr-Ptase_nr3, 2 hits |
PRINTSi | PR00935, BAND41 PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01196, FERM_C, 1 hit SM00228, PDZ, 1 hit SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF50156, SSF50156, 1 hit SSF52799, SSF52799, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit PS50106, PDZ, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z9V1_HUMAN | |
Accessioni | B7Z9V1Primary (citable) accession number: B7Z9V1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |