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UniProtKB - B7Z9S8 (B7Z9S8_HUMAN)
Protein
Sodium/potassium-transporting ATPase subunit beta
Gene
ATP1B1
Organism
Homo sapiens (Human)
Status
Functioni
Involved in cell adhesion and establishing epithelial cell polarity.
ARBA annotationThis is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
ARBA annotationGO - Biological processi
- cell adhesion Source: UniProtKB-KW
- potassium ion transport Source: UniProtKB-KW
- sodium ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Cell adhesionARBA annotation, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transportARBA annotation, Transport |
Ligand | Potassium, Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit betaUniRule annotation |
Gene namesi | Name:ATP1B1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:804, ATP1B1 |
VEuPathDBi | HostDB:ENSG00000143153 |
Subcellular locationi
Plasma membrane
- Apical cell membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
- sarcolemma ARBA annotation
- Cell membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Other locations
- Membrane UniRule annotation
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- sarcolemma Source: UniProtKB-SubCell
- sodium:potassium-exchanging ATPase complex Source: InterPro
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlutathionylationARBA annotation, GlycoproteinARBA annotationProteomic databases
MaxQBi | B7Z9S8 |
PeptideAtlasi | B7Z9S8 |
PRIDEi | B7Z9S8 |
ProteomicsDBi | 7043 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143153, Expressed in subthalamic nucleus and 253 other tissues |
ExpressionAtlasi | V9GYR2, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal-anchorARBA annotation, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
GeneTreei | ENSGT01030000234579 |
HOGENOMi | CLU_057702_1_2_1 |
OMAi | ECKAYGQ |
Family and domain databases
Gene3Di | 2.60.40.1660, 1 hit |
InterProi | View protein in InterPro IPR000402, Na/K_ATPase_sub_beta IPR015565, Na/K_ATPase_sub_beta_chordates IPR038702, Na/K_ATPase_sub_beta_sf |
PANTHERi | PTHR11523, PTHR11523, 1 hit PTHR11523:SF10, PTHR11523:SF10, 1 hit |
Pfami | View protein in Pfam PF00287, Na_K-ATPase, 1 hit |
TIGRFAMsi | TIGR01107, Na_K_ATPase_bet, 1 hit |
PROSITEi | View protein in PROSITE PS00391, ATPASE_NA_K_BETA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
B7Z9S8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLTISEFKP TYQDRVAPPG LTQIPQIQKT EISFRPNDPK SYEAYVLNIV
60 70 80 90 100
RFLEKYKDSA QRDDMIFEDC GDVPSEPKER GDFNHERGER KVCRFKLEWL
110 120 130 140 150
GNCSGLNDET YGYKEGKPCI IIKLNRVLGF KPKPPKNESL ETYPVMKYNP
160 170 180 190 200
NVLPVQCTGK RDEDKDKVGN VEYFGLGNSP GFPLQYYPYY GKLLQPKYLQ
210 220 230 240
PLLAVQFTNL TMDTEIRIEC KAYGENIGYS EKDRFQGRFD VKIEVKS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP05026 | AT1B1_HUMAN | Sodium/potassium-transporting ATPas... | ATP1B1 ATP1B | 303 | Annotation score: | ||
A0A8I5KNT2 | A0A8I5KNT2_HUMAN | Sodium/potassium-transporting ATPas... | ATP1B1 | 318 | Annotation score: | ||
A0A8I5KX89 | A0A8I5KX89_HUMAN | Sodium/potassium-transporting ATPas... | ATP1B1 | 183 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031726 Genomic DNA No translation available. Z99758 Genomic DNA No translation available. AK316043 mRNA Translation: BAH14414.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031726 Genomic DNA No translation available. Z99758 Genomic DNA No translation available. AK316043 mRNA Translation: BAH14414.1 |
3D structure databases
SMRi | B7Z9S8 |
ModBasei | Search... |
Proteomic databases
MaxQBi | B7Z9S8 |
PeptideAtlasi | B7Z9S8 |
PRIDEi | B7Z9S8 |
ProteomicsDBi | 7043 |
Protocols and materials databases
Antibodypediai | 2485, 332 antibodies from 37 providers |
Genome annotation databases
Organism-specific databases
HGNCi | HGNC:804, ATP1B1 |
OpenTargetsi | ENSG00000143153 |
VEuPathDBi | HostDB:ENSG00000143153 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01030000234579 |
HOGENOMi | CLU_057702_1_2_1 |
OMAi | ECKAYGQ |
Miscellaneous databases
ChiTaRSi | ATP1B1, human |
Gene expression databases
Bgeei | ENSG00000143153, Expressed in subthalamic nucleus and 253 other tissues |
ExpressionAtlasi | V9GYR2, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.1660, 1 hit |
InterProi | View protein in InterPro IPR000402, Na/K_ATPase_sub_beta IPR015565, Na/K_ATPase_sub_beta_chordates IPR038702, Na/K_ATPase_sub_beta_sf |
PANTHERi | PTHR11523, PTHR11523, 1 hit PTHR11523:SF10, PTHR11523:SF10, 1 hit |
Pfami | View protein in Pfam PF00287, Na_K-ATPase, 1 hit |
TIGRFAMsi | TIGR01107, Na_K_ATPase_bet, 1 hit |
PROSITEi | View protein in PROSITE PS00391, ATPASE_NA_K_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z9S8_HUMAN | |
Accessioni | B7Z9S8Primary (citable) accession number: B7Z9S8 Secondary accession number(s): V9GYR2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | May 25, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |