UniProtKB - B7Z9I1 (B7Z9I1_HUMAN)
Protein
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Gene
ACADM
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- H+ + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- H+ + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- H+ + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- H+ + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- H+ + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]ARBA annotationEC:1.3.8.7ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- decanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- dodecanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
Cofactori
FADUniRule annotationARBA annotation
: mitochondrial fatty acid beta-oxidation Pathwayi
This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.ARBA annotationView all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 131 | Substrate; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 180 | SubstrateUniRule annotation | 1 | |
Active sitei | 365 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 366 | Substrate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 377 | SubstrateUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 122 – 131 | FADUniRule annotation | 10 | |
Nucleotide bindingi | 155 – 157 | FADUniRule annotation | 3 | |
Nucleotide bindingi | 270 – 272 | FADUniRule annotation | 3 | |
Nucleotide bindingi | 280 – 281 | FADUniRule annotation | 2 | |
Nucleotide bindingi | 338 – 342 | FADUniRule annotation | 5 | |
Nucleotide bindingi | 367 – 369 | FADUniRule annotation | 3 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: UniProtKB-UniRule
- medium-chain-acyl-CoA dehydrogenase activity Source: InterPro
GO - Biological processi
- fatty acid beta-oxidation Source: InterPro
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Ligand | FADUniRule annotationARBA annotation, Flavoprotein |
Enzyme and pathway databases
UniPathwayi | UPA00660 |
Names & Taxonomyi
Protein namesi | Recommended name: Medium-chain specific acyl-CoA dehydrogenase, mitochondrialARBA annotation (EC:1.3.8.7ARBA annotation) |
Gene namesi | Name:ACADMImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:89, ACADM |
VEuPathDBi | HostDB:ENSG00000117054.13 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix ARBA annotation
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrion Source: HPA
PTM / Processingi
Keywords - PTMi
AcetylationARBA annotationProteomic databases
MaxQBi | B7Z9I1 |
PRIDEi | B7Z9I1 |
ProteomicsDBi | 7032 |
Expressioni
Gene expression databases
Bgeei | ENSG00000117054, Expressed in skeletal muscle tissue of rectus abdominis and 250 other tissues |
ExpressionAtlasi | B7Z9I1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 114 | Acyl-CoA_dh_NInterPro annotationAdd BLAST | 109 | |
Domaini | 121 – 219 | Acyl-CoA_dh_MInterPro annotationAdd BLAST | 99 | |
Domaini | 231 – 378 | Acyl-CoA_dh_1InterPro annotationAdd BLAST | 148 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 242 – 245 | Substrate bindingUniRule annotation | 4 |
Sequence similaritiesi
Keywords - Domaini
Transit peptideARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158429 |
HOGENOMi | CLU_018204_0_2_1 |
Family and domain databases
CDDi | cd01157, MCAD, 1 hit |
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR006089, Acyl-CoA_DH_CS IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom IPR034180, MCAD |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
PROSITEi | View protein in PROSITE PS00072, ACYL_COA_DH_1, 1 hit PS00073, ACYL_COA_DH_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
B7Z9I1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLQEFTEQQK EFQATARKFA REEIIPVAAE YDKTGEYPVP LIRRAWELGL
60 70 80 90 100
MNTHIPENCG GLGLGTFDAC LISEELAYGC TGVQTAIEGN SLGQMPIIIA
110 120 130 140 150
GNDQQKKKYL GRMTEEPLMC AYCVTEPGAG SDVAGIKTKA EKKGDEYIIN
160 170 180 190 200
GQKMWITNGG KANWYFLLAR SDPDPKAPAN KAFTGFIVEA DTPGIQIGRK
210 220 230 240 250
ELNMGQRCSD TRGIVFEDVK VPKENVLIGD GAGFKVAMGA FDKTRPVVAA
260 270 280 290 300
GAVGLAQRAL DEATKYALER KTFGKLLVEH QAISFMLAEM AMKVELARMS
310 320 330 340 350
YQRAAWEVDS GRRNTYYASI AKAFAGDIAN QLATDAVQIL GGNGFNTEYP
360 370 380
VEKLMRDAKI YQIYEGTSQI QRLIVAREHI DKYKN
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP11310 | ACADM_HUMAN | Medium-chain specific acyl-CoA dehy... | ACADM | 421 | Annotation score: | ||
Q5T4U5 | Q5T4U5_HUMAN | Medium-chain specific acyl-CoA dehy... | ACADM hCG_22915 | 454 | Annotation score: | ||
E9PJM9 | E9PJM9_HUMAN | Medium-chain-specific acyl-CoA dehy... | ACADM | 104 | Annotation score: | ||
E9PRX4 | E9PRX4_HUMAN | Medium-chain-specific acyl-CoA dehy... | ACADM | 76 | Annotation score: | ||
H0YDT5 | H0YDT5_HUMAN | Medium-chain-specific acyl-CoA dehy... | ACADM | 67 | Annotation score: | ||
E9PQA8 | E9PQA8_HUMAN | Medium-chain-specific acyl-CoA dehy... | ACADM | 45 | Annotation score: | ||
E9PLN7 | E9PLN7_HUMAN | Medium-chain-specific acyl-CoA dehy... | ACADM | 50 | Annotation score: | ||
E9PIX8 | E9PIX8_HUMAN | Acyl-CoA dehydrogenase C-4 to C-12 ... | ACADM | 47 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL357314 Genomic DNA No translation available. AK315946 mRNA Translation: BAH14317.1 |
RefSeqi | NP_001272971.1, NM_001286042.1 |
Genome annotation databases
Ensembli | ENST00000541113; ENSP00000442324; ENSG00000117054 |
GeneIDi | 34 |
UCSCi | uc010ore.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL357314 Genomic DNA No translation available. AK315946 mRNA Translation: BAH14317.1 |
RefSeqi | NP_001272971.1, NM_001286042.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B7Z9I1, 1 interactor |
Proteomic databases
MaxQBi | B7Z9I1 |
PRIDEi | B7Z9I1 |
ProteomicsDBi | 7032 |
Protocols and materials databases
Antibodypediai | 1642, 438 antibodies |
Genome annotation databases
Ensembli | ENST00000541113; ENSP00000442324; ENSG00000117054 |
GeneIDi | 34 |
UCSCi | uc010ore.4, human |
Organism-specific databases
CTDi | 34 |
HGNCi | HGNC:89, ACADM |
OpenTargetsi | ENSG00000117054 |
VEuPathDBi | HostDB:ENSG00000117054.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158429 |
HOGENOMi | CLU_018204_0_2_1 |
Enzyme and pathway databases
UniPathwayi | UPA00660 |
Miscellaneous databases
BioGRID-ORCSi | 34, 2 hits in 870 CRISPR screens |
ChiTaRSi | ACADM, human |
GenomeRNAii | 34 |
Gene expression databases
Bgeei | ENSG00000117054, Expressed in skeletal muscle tissue of rectus abdominis and 250 other tissues |
ExpressionAtlasi | B7Z9I1, baseline and differential |
Family and domain databases
CDDi | cd01157, MCAD, 1 hit |
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR006089, Acyl-CoA_DH_CS IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom IPR034180, MCAD |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
PROSITEi | View protein in PROSITE PS00072, ACYL_COA_DH_1, 1 hit PS00073, ACYL_COA_DH_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z9I1_HUMAN | |
Accessioni | B7Z9I1Primary (citable) accession number: B7Z9I1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |