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Protein

Tyrosine-protein phosphatase non-receptor type

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act at junctions between the membrane and the cytoskeleton.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei766SubstrateUniRule annotation1
Active sitei797Phosphocysteine intermediateUniRule annotation1
Binding sitei841SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiB7Z948
PRIDEiB7Z948

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB7Z948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 312FERMInterPro annotationAdd BLAST284
Domaini465 – 537PDZInterPro annotationAdd BLAST73
Domaini601 – 856Tyrosine-protein phosphataseInterPro annotationAdd BLAST256
Domaini774 – 847TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni797 – 803Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000007048
HOVERGENiHBG008322

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 2 hits
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRLRALGG RINNIRTSEL PKEKTRSEVI CSIHFLDGVV QTFKVTKQDT
60 70 80 90 100
GQVLLDMVHN HLGVTEKEYF GLQHDDDSVD SPRWLEASKP IRKQLKGGFP
110 120 130 140 150
CTLHFRVRFF IPDPNTLQQE QTRHLYFLQL KMDICEGRLT CPLNSAVVLA
160 170 180 190 200
SYAVQSHFGD YNSSIHHPGY LSDSHFIPDQ NEDFLTKVES LHEQHSGLKQ
210 220 230 240 250
SEAESCYINI ARTLDFYGVE LHSGRDLHNL DLMIGIASAG VAVYRKYICT
260 270 280 290 300
SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS
310 320 330 340 350
CVEHHTFFQA KKLLPQEKNV LSQYWTMGSR NTKKRSPRLR HEIRKPRHSS
360 370 380 390 400
ADNLANEMTY ITETEDVFYT YKGSLAPQDS DSEVSQNRSP HQESLSENNP
410 420 430 440 450
AQSYLTQKSS SSVSPSSNAP GSCSPDGVDQ QLLDDFHRVT KGGSTEDASQ
460 470 480 490 500
YYCDKNDNGD SYLVLIRITP DEDGKFGFNL KGGVDQKMPL VVSRINPESP
510 520 530 540 550
ADTCIPKLNE GDQIVLINGR DISEHTHDQV VMFIKASRES HSRELALVIR
560 570 580 590 600
RRAVRSFADF KSEDELNQLF PEAIFPMCPE GGDTLEGSMA QLKKGLESGT
610 620 630 640 650
VLIQFEQLYR KKPGLAITFA KLPQNLDKNR YKDVLPYDTT RVLLQGNEDY
660 670 680 690 700
INASYVNMEI PAANLVNKYI ATQGPLPHTC AQFWQVVWDQ KLSLIVMLTT
710 720 730 740 750
LTERGRTKCH QYWPDPPDVM NHGGFHIQCQ SEDCTIAYVS REMLVTNTQT
760 770 780 790 800
GEEHTVTHLQ YVAWPDHGVP DGSSDFLEFV NYVRSLRVDS EPVLVHCSAG
810 820 830 840 850
IGRTGVLVTM ETAMCLTERN LPIYPLDIVR KMRDQRAMMV QTSSQYKFVC
860
EAILRVYEEG LVQMLDPS
Length:868
Mass (Da):98,866
Last modified:March 3, 2009 - v1
Checksum:i9831EF9DBD7EF8D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304434 mRNA Translation: BAH14184.1
UniGeneiHs.436429

Similar proteinsi

Entry informationi

Entry nameiB7Z948_HUMAN
AccessioniPrimary (citable) accession number: B7Z948
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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