UniProtKB - B7Z896 (B7Z896_HUMAN)
Protein
Kinesin-like protein
Gene
KIFC3
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 386 – 393 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- ATP-dependent microtubule motor activity, minus-end-directed Source: InterPro
- microtubule binding Source: InterPro
GO - Biological processi
- microtubule-based movement Source: InterPro
Keywordsi
Molecular function | Motor proteinPROSITE-ProRule annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like proteinUniRule annotation |
Gene namesi | Name:KIFC3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6326, KIFC3 |
VEuPathDBi | HostDB:ENSG00000140859.15 |
Subcellular locationi
Cytoskeleton
- microtubule Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonARBA annotation, MicrotubuleUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000140859, Expressed in cortex of kidney and 182 other tissues |
ExpressionAtlasi | B7Z896, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 306 – 626 | Kinesin motorInterPro annotationAdd BLAST | 321 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 645 – 684 | DisorderedSequence analysisAdd BLAST | 40 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 4 – 24 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 38 – 93 | Sequence analysisAdd BLAST | 56 | |
Coiled coili | 140 – 206 | Sequence analysisAdd BLAST | 67 | |
Coiled coili | 265 – 292 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 656 – 684 | PolarSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000154022 |
OrthoDBi | 364605at2759 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027325, KIFC3-like IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR47972:SF5, PTHR47972:SF5, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All
B7Z896-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVENERLRQE MRRCEAELQE LRTKPAGPCP GCEHSQESAQ LRDKLSQLQL
60 70 80 90 100
EMAESKGMLS ELNLEVQQKT DRLAEVELRL KDCLAEKAQE EERLSRRLRD
110 120 130 140 150
SHETIASLRA QSPPVKYVIK TVEVESSKTK QALSESQARN QHLQEQVAMQ
160 170 180 190 200
RQVLKEMEQQ LQSSHQLTAR LRAQIAMYES ELERAHGQML EEMQSLEEDK
210 220 230 240 250
NRAIEEAFAR AQVEMKAVHE NLAGVRTNLL TLQPALRTLT NDYNGLKRQV
260 270 280 290 300
RGFPLLLQEA LRSVKAEIGQ AIEEVNSNNQ ELLRKYRREL QLRKKCHNEL
310 320 330 340 350
VRLKGNIRVI ARVRPVTKED GEGPEATNAV TFDADDDSII HLLHKGKPVS
360 370 380 390 400
FELDKVFSPQ ASQQDEVQAL VTSCIDGFNV CIFAYGQTGA GKTYTMEGTA
410 420 430 440 450
ENPGINQRAL QLLFSEVQEK ASDWEYTITV SAAEIYNEVL RDLLGKEPQE
460 470 480 490 500
KLEIRLCPDG SGQLYVPGLT EFQVQSVDDI NKVFEFGHTN RTTEFTNLNE
510 520 530 540 550
HSSRSHALLI VTVRGVDCST GLRTTGKLNL VDLAGSERVG KSGAEGSRLR
560 570 580 590 600
EAQHINKSLS ALGDVIAALR SRQGHVPFRN SKLTYLLQDS LSGDSKTLMV
610 620 630 640 650
VQVSPVEKNT SETLYSLKFA ERVRSVELGP GLRRAELGSW SSQEHLEWEP
660 670 680
ACQTPQPSAR AHSAPSSGTS SRPGSIRRKL QPSA
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BVG8 | KIFC3_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 833 | Annotation score: | ||
F5H3M2 | F5H3M2_HUMAN | Kinesin-like protein | KIFC3 | 724 | Annotation score: | ||
H3BTL6 | H3BTL6_HUMAN | Kinesin-like protein | KIFC3 | 280 | Annotation score: | ||
A0A0C4DGM9 | A0A0C4DGM9_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 498 | Annotation score: | ||
H3BUC0 | H3BUC0_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 196 | Annotation score: | ||
H3BTU1 | H3BTU1_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 147 | Annotation score: | ||
H3BPE2 | H3BPE2_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 132 | Annotation score: | ||
H3BSN2 | H3BSN2_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 190 | Annotation score: | ||
H3BMQ3 | H3BMQ3_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 167 | Annotation score: | ||
H3BMR0 | H3BMR0_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 70 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010543 Genomic DNA No translation available. AC092118 Genomic DNA No translation available. FO082293 Genomic DNA No translation available. AK303021 mRNA Translation: BAH13882.1 |
RefSeqi | NP_001305642.1, NM_001318713.1 |
Genome annotation databases
Ensembli | ENST00000543930; ENSP00000444012; ENSG00000140859 |
GeneIDi | 3801 |
UCSCi | uc010vhx.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010543 Genomic DNA No translation available. AC092118 Genomic DNA No translation available. FO082293 Genomic DNA No translation available. AK303021 mRNA Translation: BAH13882.1 |
RefSeqi | NP_001305642.1, NM_001318713.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B7Z896 |
PRIDEi | B7Z896 |
ProteomicsDBi | 6935 |
Protocols and materials databases
Antibodypediai | 15192, 94 antibodies |
DNASUi | 3801 |
Genome annotation databases
Ensembli | ENST00000543930; ENSP00000444012; ENSG00000140859 |
GeneIDi | 3801 |
UCSCi | uc010vhx.3, human |
Organism-specific databases
CTDi | 3801 |
HGNCi | HGNC:6326, KIFC3 |
OpenTargetsi | ENSG00000140859 |
VEuPathDBi | HostDB:ENSG00000140859.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154022 |
OrthoDBi | 364605at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3801, 1 hit in 992 CRISPR screens |
ChiTaRSi | KIFC3, human |
GenomeRNAii | 3801 |
Gene expression databases
Bgeei | ENSG00000140859, Expressed in cortex of kidney and 182 other tissues |
ExpressionAtlasi | B7Z896, baseline and differential |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027325, KIFC3-like IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR47972:SF5, PTHR47972:SF5, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z896_HUMAN | |
Accessioni | B7Z896Primary (citable) accession number: B7Z896 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | April 7, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |