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Entry version 42 (31 Jul 2019)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

cDNA FLJ61672, highly similar to Proteoglycan-4

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ61672, highly similar to Proteoglycan-4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500286677825 – 904Sequence analysisAdd BLAST880

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B7Z759

PRoteomics IDEntifications database

More...
PRIDEi
B7Z759

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 67SMBInterPro annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 904DisorderedSequence analysisAdd BLAST838

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 94PolarSequence analysisAdd BLAST15
Compositional biasi102 – 119PolyampholyteSequence analysisAdd BLAST18
Compositional biasi120 – 144PolarSequence analysisAdd BLAST25
Compositional biasi145 – 159PolyampholyteSequence analysisAdd BLAST15
Compositional biasi190 – 215PolarSequence analysisAdd BLAST26
Compositional biasi224 – 259PolarSequence analysisAdd BLAST36
Compositional biasi260 – 274PolyampholyteSequence analysisAdd BLAST15
Compositional biasi307 – 321Pro-richSequence analysisAdd BLAST15
Compositional biasi322 – 355PolarSequence analysisAdd BLAST34
Compositional biasi356 – 375Pro-richSequence analysisAdd BLAST20
Compositional biasi376 – 391PolarSequence analysisAdd BLAST16
Compositional biasi392 – 480Pro-richSequence analysisAdd BLAST89
Compositional biasi481 – 511PolarSequence analysisAdd BLAST31
Compositional biasi512 – 574Pro-richSequence analysisAdd BLAST63
Compositional biasi575 – 591PolarSequence analysisAdd BLAST17
Compositional biasi592 – 662Pro-richSequence analysisAdd BLAST71
Compositional biasi663 – 678PolarSequence analysisAdd BLAST16
Compositional biasi695 – 713PolarSequence analysisAdd BLAST19
Compositional biasi714 – 736Pro-richSequence analysisAdd BLAST23
Compositional biasi764 – 782PolarSequence analysisAdd BLAST19
Compositional biasi783 – 813Pro-richSequence analysisAdd BLAST31
Compositional biasi814 – 838PolarSequence analysisAdd BLAST25
Compositional biasi885 – 904PolarSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1565 Eukaryota
ENOG410XQ5D LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115691

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01033 Somatomedin_B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00022 SOMATOMEDINB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00201 SO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90188 SSF90188, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

B7Z759-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWKTLPIYL LLLLSVFVIQ QVSSQELSCK GRCFESFERG RECDCDAQCK
60 70 80 90 100
KYDKCCPDYE SFCAEVHNPT SPPSSKKAPP PSGASQTIKS TTKRSPKPPN
110 120 130 140 150
KKKTKKVIES EEITEEHSVS ENQESSSSSS SSSSSSTIRK IKSSKNSAAN
160 170 180 190 200
RELQKKLKVK DNKKNRTKKK PTPKPPVVDE AGSGLDNGDF KVTTPDTSTT
210 220 230 240 250
QHNKVSTSPK ITTAKPINPR PSLPPNSDTS KETSLTVNKE TTVETKETTT
260 270 280 290 300
TNKQTSTDGK EKTTSAKETQ SIEKTSAKDL APTSKVLAKP TPKAETTTKG
310 320 330 340 350
PALTTPKEPT PTTPKEPAST TPKEPTPTTI KSAPTTPKEP APTTTKSAPT
360 370 380 390 400
TPKEPAPTTT KEPAPTTPKE PAPTTTKEPA PTTTKSAPTT PKEPAPTTPK
410 420 430 440 450
KPAPTTPKEP APTTPKEPTP TTPKEPAPTT KEPAPTTPKE PAPTAPKKPA
460 470 480 490 500
PTTPKEPAPT TPKEPAPTTT KEPSPTTPKE PAPTTTKSAP TTTKEPAPTT
510 520 530 540 550
TKSAPTTPKE PSPTTTKEPA PTTPKEPAPT TPKKPAPTTP KEPAPTTPKE
560 570 580 590 600
PAPTTTKKPA PTTPKEPAPT TPKETAPTTP KKLTPTTPEK LAPTTPEKPA
610 620 630 640 650
PTTPEELAPT TPEEPTPTTP EEPAPTTPKA AAPNTPKEPA PTTPKEPAPT
660 670 680 690 700
TPKEPAPTTP KETAPTTPKG TAPTTLKEPA PTTPKKPAPK ELAPTTTKEP
710 720 730 740 750
TSTTSDKPAP TTPKGTAPTT PKEPAPTTPK EPAPTTPKGT APTTLKEPAP
760 770 780 790 800
TTPKKPAPKE LAPTTTKGPT STTSDKPAPT TPKETAPTTP KEPAPTTPKK
810 820 830 840 850
PAPTTPETPP PTTSEVSTPT TTKEPTTIHK SPDESTPELS AEPTPKALEN
860 870 880 890 900
SPKEPGVPTT KTPAATKPEM TTTAKDKTTE RDLRTTPETT TAAPKMTKET

ATTT
Length:904
Mass (Da):94,839
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFF7B62DCBFBD00E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei904Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK301487 mRNA Translation: BAH13495.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301487 mRNA Translation: BAH13495.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB7Z759
PRIDEiB7Z759

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
HOGENOMiHOG000115691

Family and domain databases

InterProiView protein in InterPro
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF01033 Somatomedin_B, 1 hit
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00201 SO, 1 hit
SUPFAMiSSF90188 SSF90188, 1 hit
PROSITEiView protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7Z759_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7Z759
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 31, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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