UniProtKB - B7Z6G2 (B7Z6G2_HUMAN)
Protein
Submitted name:
cDNA FLJ56152, highly similar to Rho guanine nucleotide exchange factor 7
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: InterPro
GO - Biological processi
- intracellular signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ56152, highly similar to Rho guanine nucleotide exchange factor 7Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- lamellipodium ARBA annotation
Other locations
- lamellipodium Source: UniProtKB-SubCell
PTM / Processingi
Proteomic databases
MaxQBi | B7Z6G2 |
PeptideAtlasi | B7Z6G2 |
PRIDEi | B7Z6G2 |
ProteomicsDBi | 6777 |
Interactioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: InterPro
Protein-protein interaction databases
IntActi | B7Z6G2, 2 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 81 – 140 | SH3InterPro annotationAdd BLAST | 60 | |
Domaini | 168 – 348 | DHInterPro annotationAdd BLAST | 181 | |
Domaini | 370 – 475 | PHInterPro annotationAdd BLAST | 106 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 477 – 552 | DisorderedSequence analysisAdd BLAST | 76 | |
Regioni | 575 – 601 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 314 – 334 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 349 – 369 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 669 – 710 | Sequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 477 – 503 | PolarSequence analysisAdd BLAST | 27 | |
Compositional biasi | 585 – 601 | PolyampholyteSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
OrthoDBi | 547556at2759 |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit cd12061, SH3_betaPIX, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035789, BetaPIX_SH3 IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR032409, GEF_CC IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF16523, betaPIX_CC, 1 hit PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit PF07653, SH3_2, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50002, SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
B7Z6G2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTFDANDLY QGQNFNKVLS SLVTLNKVTA DIGLGSDSVC ARPSSHRIKS
60 70 80 90 100
FDSLGSQSLH TRTSKLFQGQ YRSLDMTDNS NNQLVVRAKF NFQQTNEDEL
110 120 130 140 150
SFSKGDVIHV TRVEEGGWWE GTLNGRTGWF PSNYVREVKA SEKPVSPKSG
160 170 180 190 200
TLKSPPKGFD TTAINKSYYN VVLQNILETE NEYSKELQTV LSTYLRPLQT
210 220 230 240 250
SEKLSSANIS YLMGNLEEIC SFQQMLVQSL EECTKLPEAQ QRVGGCFLNL
260 270 280 290 300
MPQMKTLYLT YCANHPSAVN VLTEHSEELG EFMETKGASS PGILVLTTGL
310 320 330 340 350
SKPFMRLDKY PTLLKELERH MEDYHTDRQD IQKSMAAFKN LSAQCQEVRK
360 370 380 390 400
RKELELQILT EAIRNWEGDD IKTLGNVTYM SQVLIQCAGS EEKNERYLLL
410 420 430 440 450
FPNVLLMLSA SPRMSGFIYQ GKLPTTGMTI TKLEDSENHR NAFEISGSMI
460 470 480 490 500
ERILVSCNNQ QDLQEWVEHL QKQTKVTSVG NPTIKPHSVP SHTLPSHPVT
510 520 530 540 550
PSSKHADSKP APLTPAYHTL PHPSHHGTPH TTINWGPLEP PKTPKPWSLS
560 570 580 590 600
CLRPAPPLRP SAALCYKEDL SKSPKTMKKL LPKRKPERKP SDEEFASRKS
610 620 630 640 650
TAALEEDAQI LKVIEAYCTS AKTRQTLNSS SRKESAPQVL LPEEEKIIVE
660 670 680 690 700
ETKSNGQTVI EEKSLVDTVY ALKDEVQELR QDNKKMKKSL EEEQRARKDL
710 720
EKLVRKVLKN MNDPAWDETN L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK300272 mRNA Translation: BAH13248.1 |
RefSeqi | NP_001307782.1, NM_001320853.1 |
Genome annotation databases
GeneIDi | 8874 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK300272 mRNA Translation: BAH13248.1 |
RefSeqi | NP_001307782.1, NM_001320853.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B7Z6G2, 2 interactors |
Proteomic databases
MaxQBi | B7Z6G2 |
PeptideAtlasi | B7Z6G2 |
PRIDEi | B7Z6G2 |
ProteomicsDBi | 6777 |
Genome annotation databases
GeneIDi | 8874 |
Organism-specific databases
CTDi | 8874 |
Phylogenomic databases
OrthoDBi | 547556at2759 |
Miscellaneous databases
BioGRID-ORCSi | 8874, 197 hits in 872 CRISPR screens |
GenomeRNAii | 8874 |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit cd12061, SH3_betaPIX, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035789, BetaPIX_SH3 IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR032409, GEF_CC IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF16523, betaPIX_CC, 1 hit PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit PF07653, SH3_2, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z6G2_HUMAN | |
Accessioni | B7Z6G2Primary (citable) accession number: B7Z6G2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |