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Entry version 68 (29 Sep 2021)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

cDNA FLJ51076, weakly similar to LIM domain only protein 7

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ51076, weakly similar to LIM domain only protein 7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B7Z656

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini683 – 749LIM zinc-bindingInterPro annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni289 – 338DisorderedSequence analysisAdd BLAST50
Regioni350 – 377DisorderedSequence analysisAdd BLAST28
Regioni503 – 680DisorderedSequence analysisAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili27 – 68Sequence analysisAdd BLAST42
Coiled coili82 – 112Sequence analysisAdd BLAST31
Coiled coili454 – 495Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi289 – 306Polar residuesSequence analysisAdd BLAST18
Compositional biasi307 – 321Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi359 – 375Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi503 – 533Polar residuesSequence analysisAdd BLAST31
Compositional biasi534 – 571Basic and acidic residuesSequence analysisAdd BLAST38
Compositional biasi606 – 627Polar residuesSequence analysisAdd BLAST22
Compositional biasi642 – 657Basic and acidic residuesSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis, LIM domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
298177at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031865, DUF4757
IPR029980, LIMCH1
IPR001781, Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR15551:SF3, PTHR15551:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15949, DUF4757, 1 hit
PF00412, LIM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132, LIM, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B7Z656-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFDMRCEEEA AVQPHSRARQ EQLQLINNQL REEDDKWQDD LARWKSRRRS
60 70 80 90 100
VSQDLIKKEE ERKKMEKLLA GEDGTSERRK SIKTYREIVQ EKERRERELH
110 120 130 140 150
EAYKNARSQE EAEGILQQYI ERFTISEAVL ERLEMPKILE RSHSTEPNLS
160 170 180 190 200
SFLNDPNPMK YLRQQSLPPP KFTATVETTI ARASVLDTSM SAGSGSPSKT
210 220 230 240 250
VTPKAVPMLT PKPYSQPKNS QDVLKTFKVD GKVSVNGETV HREEEKEREC
260 270 280 290 300
PTVAPAHSLT KSQMFEGVAR VHGSPLELKQ DNGSIEINIK KPNSVPQELA
310 320 330 340 350
ATTEKTEPNS QEDKNDGGKS RKGNIELASS EPQHFTTTVT RCSPTVAFVE
360 370 380 390 400
FPSSPQLKND VSEEKDQKKP ENEMSGKVEL VLSQKVVKPK SPEPEATLTF
410 420 430 440 450
PFLDKMPEAN QLHLPNLNSQ VDSPSSEKSP VMTPFKFWAW DPEEERRRQE
460 470 480 490 500
KWQQEQERLL QERYQKEQDK LKEEWEKAQK EVEEEERRYY EEERKIIEDT
510 520 530 540 550
VVPFTVSSSS ADQLSTSSSM TEGSGTMNKI DLGNCQDEKQ DRRWKKSFQG
560 570 580 590 600
DDSDLLLKTR ESDRLEEKGS LTEGALAHSG NPVSKGVHED HQLDTEAGAP
610 620 630 640 650
HCGTNPQLAQ DPSQNQQTSN PTHSSEDVKP KTLPLDKSIN HQIESPSERR
660 670 680 690 700
KKSPREHFQA GPFSPCSPTP PGQSPNRSIS GKKLCSSCGL PLGKGAAMII
710 720 730 740 750
ETLNLYFHIQ CFRCGICKGQ LGDAVSGTDV RIRNGLLNCN DCYMRSRSAG

QPTTL
Length:755
Mass (Da):85,422
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D102BA4A85C503A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK299835 mRNA Translation: BAH13142.1

NCBI Reference Sequences

More...
RefSeqi
NP_001317603.1, NM_001330674.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22998

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299835 mRNA Translation: BAH13142.1
RefSeqiNP_001317603.1, NM_001330674.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB7Z656

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22998

Genome annotation databases

GeneIDi22998

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22998

Phylogenomic databases

OrthoDBi298177at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22998, 1 hit in 1003 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22998

Family and domain databases

InterProiView protein in InterPro
IPR031865, DUF4757
IPR029980, LIMCH1
IPR001781, Znf_LIM
PANTHERiPTHR15551:SF3, PTHR15551:SF3, 1 hit
PfamiView protein in Pfam
PF15949, DUF4757, 1 hit
PF00412, LIM, 1 hit
SMARTiView protein in SMART
SM00132, LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7Z656_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7Z656
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 29, 2021
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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