UniProtKB - B7Z647 (B7Z647_HUMAN)
Protein
Submitted name:
Discs, large homolog 4 (Drosophila), isoform CRA_b
Gene
DLG4
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Discs, large homolog 4 (Drosophila), isoform CRA_bImportedSubmitted name: Disks large homolog 4ImportedSubmitted name: cDNA FLJ50646, highly similar to Discs large homolog 4ImportedSubmitted name: cDNA, FLJ78995, highly similar to Discs large homolog 4Imported |
Gene namesi | Name:DLG4Imported ORF Names:hCG_40530Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2903, DLG4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 92 | PDZInterPro annotationAdd BLAST | 88 | |
Domaini | 100 – 187 | PDZInterPro annotationAdd BLAST | 88 | |
Domaini | 253 – 334 | PDZInterPro annotationAdd BLAST | 82 | |
Domaini | 368 – 438 | SH3InterPro annotationAdd BLAST | 71 | |
Domaini | 474 – 649 | Guanylate kinase-likeInterPro annotationAdd BLAST | 176 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 603 – 623 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157956 |
OrthoDBi | 807583at2759 |
Family and domain databases
Gene3Di | 2.30.42.10, 3 hits |
InterProi | View protein in InterPro IPR016313, DLG1-like IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR027417, P-loop_NTPase IPR001478, PDZ IPR019583, PDZ_assoc IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 3 hits PF10600, PDZ_assoc, 1 hit PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF001741, MAGUK_DLGH, 2 hits |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 3 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
B7Z647-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR
60 70 80 90 100
LRVNDSILFV NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKVME
110 120 130 140 150
IKLIKGPKGL GFSIAGGVGN QHIPGDNSIY VTKIIEGGAA HKDGRLQIGD
160 170 180 190 200
KILAVNSVGL EDVMHEDAVA ALKNTYDVVY LKVAKPSNAY LSDSYAPPDI
210 220 230 240 250
TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD LLGEEDIPRE
260 270 280 290 300
PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL
310 320 330 340 350
SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ
360 370 380 390 400
LMNSSLGSGT ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ ALSFRFGDVL
410 420 430 440 450
HVIDASDEEW WQARRVHSDS ETDDIGFIPS KRRVERREWS RLKAKDWGSS
460 470 480 490 500
SGSQGREDSV LSYETVTQME VHYARPIIIL GPTKDRANDD LLSEFPDKFG
510 520 530 540 550
SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE AGQYNSHLYG
560 570 580 590 600
TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE
610 620 630 640 650
INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI YHKVKRVIED
660
LSGPYIWVPA RERL
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP78352 | DLG4_HUMAN | Disks large homolog 4 | DLG4 PSD95 | 724 | Annotation score: | ||
B9EGL1 | B9EGL1_HUMAN | DLG4 protein | DLG4 hCG_40530 | 764 | Annotation score: | ||
B7Z3U2 | B7Z3U2_HUMAN | Disks large homolog 4 | DLG4 | 667 | Annotation score: | ||
A0A3B3IS17 | A0A3B3IS17_HUMAN | Disks large homolog 4 | DLG4 | 697 | Annotation score: | ||
A0A3B3ISQ5 | A0A3B3ISQ5_HUMAN | Disks large homolog 4 | DLG4 | 757 | Annotation score: | ||
O14909 | O14909_HUMAN | Discs, large homolog 4 (Drosophila)... | DLG4 hCG_40530 | 296 | Annotation score: | ||
A0A3B3ITI9 | A0A3B3ITI9_HUMAN | Disks large homolog 4 | DLG4 | 277 | Annotation score: | ||
C9JWP9 | C9JWP9_HUMAN | Disks large homolog 4 | DLG4 | 242 | Annotation score: | ||
C9JYG3 | C9JYG3_HUMAN | Disks large homolog 4 | DLG4 | 242 | Annotation score: | ||
K7EKU8 | K7EKU8_HUMAN | Disks large homolog 4 | DLG4 | 205 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC120057 Genomic DNA No translation available. AK299801 mRNA Translation: BAH13133.1 AK316096 mRNA Translation: BAH14467.1 CH471108 Genomic DNA Translation: EAW90252.1 |
RefSeqi | NP_001308005.1, NM_001321076.1 NP_001308006.1, NM_001321077.1 NP_001356.1, NM_001365.4 XP_011522004.1, XM_011523702.1 |
Genome annotation databases
Ensembli | ENST00000649186; ENSP00000497879; ENSG00000132535 ENST00000649520; ENSP00000497647; ENSG00000132535 |
GeneIDi | 1742 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC120057 Genomic DNA No translation available. AK299801 mRNA Translation: BAH13133.1 AK316096 mRNA Translation: BAH14467.1 CH471108 Genomic DNA Translation: EAW90252.1 |
RefSeqi | NP_001308005.1, NM_001321076.1 NP_001308006.1, NM_001321077.1 NP_001356.1, NM_001365.4 XP_011522004.1, XM_011523702.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B7Z647 |
Protocols and materials databases
Antibodypediai | 1930, 847 antibodies |
DNASUi | 1742 |
Genome annotation databases
Ensembli | ENST00000649186; ENSP00000497879; ENSG00000132535 ENST00000649520; ENSP00000497647; ENSG00000132535 |
GeneIDi | 1742 |
Organism-specific databases
CTDi | 1742 |
HGNCi | HGNC:2903, DLG4 |
OpenTargetsi | ENSG00000132535 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157956 |
OrthoDBi | 807583at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1742, 9 hits in 997 CRISPR screens |
ChiTaRSi | DLG4, human |
GenomeRNAii | 1742 |
Gene expression databases
ExpressionAtlasi | B7Z647, baseline and differential |
Family and domain databases
Gene3Di | 2.30.42.10, 3 hits |
InterProi | View protein in InterPro IPR016313, DLG1-like IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR027417, P-loop_NTPase IPR001478, PDZ IPR019583, PDZ_assoc IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 3 hits PF10600, PDZ_assoc, 1 hit PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF001741, MAGUK_DLGH, 2 hits |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 3 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B7Z647_HUMAN | |
Accessioni | B7Z647Primary (citable) accession number: B7Z647 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | April 7, 2021 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |