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Entry version 87 (16 Oct 2019)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Heterogeneous nuclear ribonucleoprotein Q

Gene

SYNCRIP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoproteinImported, RNA-bindingPROSITE-ProRule annotation, Viral nucleoproteinImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Heterogeneous nuclear ribonucleoprotein QImported
Submitted name:
Synaptotagmin binding, cytoplasmic RNA interacting protein, isoform CRA_bImported
Submitted name:
cDNA FLJ50849, highly similar to Heterogeneous nuclear ribonucleoprotein QImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNCRIPImported
ORF Names:hCG_401112Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16918 SYNCRIP

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Virion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    Open Targets

    More...
    OpenTargetsi
    ENSG00000135316

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134985065

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    B7Z645

    PeptideAtlas

    More...
    PeptideAtlasi
    B7Z645

    PRoteomics IDEntifications database

    More...
    PRIDEi
    B7Z645

    PTM databases

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    B7Z645

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000135316 Expressed in 234 organ(s), highest expression level in tendon

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    B7Z645 baseline and differential

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 143RRMInterPro annotationAdd BLAST80
    Domaini145 – 227RRMInterPro annotationAdd BLAST83
    Domaini240 – 310RRMInterPro annotationAdd BLAST71

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
    Regioni399 – 464DisorderedSequence analysisAdd BLAST66

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0117 Eukaryota
    ENOG410XTJ5 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153511

    Database of Orthologous Groups

    More...
    OrthoDBi
    1384330at2759

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd12483 RRM1_hnRNPQ, 1 hit
    cd12489 RRM2_hnRNPQ, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.70.330, 3 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006535 HnRNP_R/Q_splicing_fac
    IPR034544 hnRNPQ_RRM1
    IPR034548 hnRNPQ_RRM2
    IPR012677 Nucleotide-bd_a/b_plait_sf
    IPR035979 RBD_domain_sf
    IPR000504 RRM_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00076 RRM_1, 3 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00360 RRM, 3 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF54928 SSF54928, 3 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01648 hnRNP-R-Q, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50102 RRM, 3 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    B7Z645-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKTYRQREKQ GTKVADSSKG PDEAKIKALL ERTGYTLDVT TGQRKYGGPP
    60 70 80 90 100
    PDSVYSGQQP SVGTEIFVGK IPRDLFEDEL VPLFEKAGPI WDLRLMMDPL
    110 120 130 140 150
    TGLNRGYAFV TFCTKEAAQE AVKLYNNHEI RSGKHIGVCI SVANNRLFVG
    160 170 180 190 200
    SIPKSKTKEQ ILEEFSKVTE GLTDVILYHQ PDDKKKNRGF CFLEYEDHKT
    210 220 230 240 250
    AAQARRRLMS GKVKVWGNVG TVEWADPIED PDPEVMAKVK VLFVRNLANT
    260 270 280 290 300
    VTEEILEKAF SQFGKLERVK KLKDYAFIHF DERDGAVKAM EEMNGKDLEG
    310 320 330 340 350
    ENIEIVFAKP PDQKRKERKA QRQAAKNQMY DDYYYYGPPH MPPPTRGRGR
    360 370 380 390 400
    GGRGGYGYPP DYYGYEDYYD YYGYDYHNYR GGYEDPYYGY EDFQVGARGR
    410 420 430 440 450
    GGRGARGAAP SRGRGAAPPR GRAGYSQRGG PGSARGVRGA RGGAQQQRGR
    460
    GQGKGVEAGP DLLQ
    Length:464
    Mass (Da):52,047
    Last modified:March 3, 2009 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A0ED156A86D27CB
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    O60506HNRPQ_HUMAN
    Heterogeneous nuclear ribonucleopro...
    SYNCRIP HNRPQ, NSAP1
    623Annotation score:

    Annotation score:5 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F6UXX1F6UXX1_HUMAN
    Heterogeneous nuclear ribonucleopro...
    SYNCRIP
    185Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AL136082 Genomic DNA No translation available.
    AK299796 mRNA Translation: BAH13131.1
    CH471051 Genomic DNA Translation: EAW48623.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001153145.1, NM_001159673.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000616122; ENSP00000484577; ENSG00000135316

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    10492

    UCSC genome browser

    More...
    UCSCi
    uc003pky.4 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AL136082 Genomic DNA No translation available.
    AK299796 mRNA Translation: BAH13131.1
    CH471051 Genomic DNA Translation: EAW48623.1
    RefSeqiNP_001153145.1, NM_001159673.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    PTM databases

    SwissPalmiB7Z645

    Proteomic databases

    MaxQBiB7Z645
    PeptideAtlasiB7Z645
    PRIDEiB7Z645

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    10492

    Genome annotation databases

    EnsembliENST00000616122; ENSP00000484577; ENSG00000135316
    GeneIDi10492
    UCSCiuc003pky.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    10492
    HGNCiHGNC:16918 SYNCRIP
    OpenTargetsiENSG00000135316
    PharmGKBiPA134985065

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0117 Eukaryota
    ENOG410XTJ5 LUCA
    GeneTreeiENSGT00940000153511
    OrthoDBi1384330at2759

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SYNCRIP human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    10492

    Gene expression databases

    BgeeiENSG00000135316 Expressed in 234 organ(s), highest expression level in tendon
    ExpressionAtlasiB7Z645 baseline and differential

    Family and domain databases

    CDDicd12483 RRM1_hnRNPQ, 1 hit
    cd12489 RRM2_hnRNPQ, 1 hit
    Gene3Di3.30.70.330, 3 hits
    InterProiView protein in InterPro
    IPR006535 HnRNP_R/Q_splicing_fac
    IPR034544 hnRNPQ_RRM1
    IPR034548 hnRNPQ_RRM2
    IPR012677 Nucleotide-bd_a/b_plait_sf
    IPR035979 RBD_domain_sf
    IPR000504 RRM_dom
    PfamiView protein in Pfam
    PF00076 RRM_1, 3 hits
    SMARTiView protein in SMART
    SM00360 RRM, 3 hits
    SUPFAMiSSF54928 SSF54928, 3 hits
    TIGRFAMsiTIGR01648 hnRNP-R-Q, 1 hit
    PROSITEiView protein in PROSITE
    PS50102 RRM, 3 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB7Z645_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B7Z645
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 16, 2019
    This is version 87 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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